Elsevier

Genetics in Medicine

Volume 10, Issue 2, February 2008, Pages 83-88
Genetics in Medicine

Review
Association study between interleukin 1β gene and epileptic disorders: a HuGe review and meta-analysis

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Abstract

Previous studies have examined the association of a single nucleotide polymorphism at the promoter region of interleukin 1B (IL-1β-511T) with temporal lobe epilepsy and febrile seizures susceptibility, but those studies have been inconclusive. Published studies up to March 2007 of temporal lobe epilepsy, febrile seizures and the IL-1β-511T single nucleotide polymorphism were identified by searches of Medline and Embase databases. Meta-analysis of temporal lobe epilepsy and febrile seizures case-control data were performed to assess the association of IL-1β-511T with temporal lobe epilepsy, temporal lobe epilepsy with hippocampal sclerosis, febrile seizures, and other epileptic disorders. Pooled odds ratios (OR) were estimated by means of a genetic-model-free approach. The quality of the included studies was assessed by a score. The results show a modest association (OR, 1.48; 95% confidence interval, 1.09–2.00; P = 0.01) between the IL-1β-511T polymorphism and temporal lobe epilepsy with hippocampal sclerosis.

Keywords

temporal lobe epilepsy
hippocampal sclerosis
interleukin 1B
IL-1β
meta-analysis

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