Elsevier

Journal of Thoracic Oncology

Volume 5, Issue 12, December 2010, Pages 1953-1957
Journal of Thoracic Oncology

Original Article
Derivation of Utility Values from European Organization for Research and Treatment of Cancer Quality of Life-Core 30 Questionnaire Values in Lung Cancer

https://doi.org/10.1097/JTO.0b013e3181f77a6aGet rights and content
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Introduction

Cancer clinical trials frequently incorporate quality of life (QoL) measures but rarely patient utility. Utility information is required for cost utility evaluations of novel cancer therapies. We assessed the feasibility of converting QoL data into utility scores using the European Organization for Research and Treatment of Cancer Quality of Life-Core 30 questionnaire (EORTC QLQ-C30) and the EQ-5D in patients with non-small cell lung cancer (NSCLC).

Methods

Outpatients with all different disease states of NSCLC attending a major Canadian cancer center completed the QLQ-C30 and EQ5D on a single visit. Results of the QLQ-C30 summary scores were mapped to predict EQ-5D utility scores using linear regression. Backward variable elimination using the Akaike Information Criterion was used to reduce the full model that included all QLQ-C30 summary scores to examine which QLQ-C30 dimensions best predict a patient's utility score. To test the predictive power of the model, 10-fold cross-validation was used.

Results

A total of 172 patients participated in the study. Median age of the sample was 66 years (range, 32–85 years); 46.5% were men. The cross-validation estimate of mean utility score was 0.76 (SD: 0.20), which was the same as the actual mean utility score. Of the 15 QLQ-C30 dimensions, 4 functional dimensions (physical, role, emotional, and social) and the pain symptom dimension were predictive of patient utility scores.

Conclusions

Our study demonstrates the feasibility of deriving utility scores from prospective QoL data. Validation of the QLQ-C30 predictors found in this study could further the ability to estimate cost utility of therapies for economic evaluations.

Key Words

Non-small cell lung cancer
EQ-5D
EORTC QLQ-C30
Derivation of utility values
Economic evaluation

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Disclosure: The authors declare no conflict of interest.

Presented in part at the 13th Annual Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR), Toronto, 2008, and the 13th World Conference on Lung Cancer, San Francisco, 2009.

Jang and Isogai contributed equally to this article. Jang received a Young Investigator Travel Award at the 13th World Conference on Lung Cancer.