Francisella tularensis: unravelling the secrets of an intracellular pathogen

References

1. Ancuta P., Pedron T., Girard R., Sandstrom G., Chaby R. 1996; Inability of the Francisella tularensis lipopolysaccharide to mimic or to antagonize the induction of the cell activation by endotoxins. Infect Immun 64:2041–2046
   [Google Scholar]
2. Anthony L. D., Burke R. D., Nano F. E. 1991; Growth of Francisella spp. in rodent macrophages. Infect Immun 59:3291–3296
   [Google Scholar]
3. Barker J. H., Weiss J., Apicella M. A., Nauseef W. M. 2006; Basis for the failure of Francisella tularensis lipopolysaccharide to prime human polymorphonuclear leukocytes. Infect Immun 74:3277–3284 [CrossRef]
   [Google Scholar]
4. Baron G. S., Nano F. E. 1998; MgIA and MgIB are required for the intramacrophage growth of Francisella novicida . Mol Microbiol 29:247–259 [CrossRef]
   [Google Scholar]
5. Baron G. S., Nano F. E. 1999; An erythromycin resistance cassette and mini-transposon for constructing transcriptional fusions to cat. Gene 229:59–65 [CrossRef]
   [Google Scholar]
6. Beckstrom-Sternberg S. M., Auerbach R. K., Godbole S., Pearson J. V., Beckstrom-Sternberg J. S., Deng Z., Munk C., Kubota K., Zhou Y. other authors 2007; Complete genomic characterization of a pathogenic A.II strain of Francisella tularensis subspecies tularensis . PLoS ONE 2:e947 [CrossRef]
   [Google Scholar]
7. Ben Nasr A., Haithcoat J., Masterson J. E., Gunn J. S., Eaves-Pyles T., Klimpel G. R. 2006; Critical role for serum opsonins and complement receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in phagocytosis of Francisella tularensis by human dendritic cells (DC): uptake of Francisella leads to activation of immature DC and intracellular survival of the bacteria. J Leukoc Biol 80:774–786 [CrossRef]
   [Google Scholar]
8. Bina X. R., Wang C., Miller M. A., Bina J. E. 2006; The Bla2 β -lactamase from the live-vaccine strain of Francisella tularensis encodes a functional protein that is only active against penicillin-class beta-lactam antibiotics. Arch Microbiol 186:219–228 [CrossRef]
   [Google Scholar]
9. Boyce J. M. 1975; Recent trends in the epidemiology of tularemia in the United States. J Infect Dis 131:197–199 [CrossRef]
   [Google Scholar]
10. Brotcke A., Weiss D. S., Kim C. C., Chain P., Malfatti S., Garcia E., Monack D. M. 2006; Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis . Infect Immun 74:6642–6655 [CrossRef]
    [Google Scholar]
11. Buddingh G. J., Womack F. C. Jr 1941; Observations on the infection of chick embryos with Bacterium tularense , Brucella , and Pasteurella pestis . J Exp Med 74:213–222 [CrossRef]
    [Google Scholar]
12. Burke D. S. 1977; Immunization against tularemia: analysis of the effectiveness of live Francisella tularensis vaccine in prevention of laboratory-acquired tularemia. J Infect Dis 135:55–60 [CrossRef]
    [Google Scholar]
13. Checroun C., Wehrly T. D., Fischer E. R., Hayes S. F., Celli J. 2006; Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication. Proc Natl Acad Sci U S A 103:14578–14583 [CrossRef]
    [Google Scholar]
14. Clemens D. L., Lee B. Y., Horwitz M. A. 2004; Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages. Infect Immun 72:3204–3217 [CrossRef]
    [Google Scholar]
15. Clemens D. L., Lee B. Y., Horwitz M. A. 2005; Francisella tularensis enters macrophages via a novel process involving pseudopod loops. Infect Immun 73:5892–5902 [CrossRef]
    [Google Scholar]
16. Conlan J. W., Shen H., Webb A., Perry M. B. 2002; Mice vaccinated with the O-antigen of Francisella tularensis LVS lipopolysaccharide conjugated to bovine serum albumin develop varying degrees of protective immunity against systemic or aerosol challenge with virulent type A and type B strains of the pathogen. Vaccine 20:3465–3471 [CrossRef]
    [Google Scholar]
17. Councilman W. T., Strong R. P. 1921; Plague-like infections in rodents. Trans Assoc Am Physicians 36:135–143
    [Google Scholar]
18. Craig L., Pique M. E., Tainer J. A. 2004; Type IV pilus structure and bacterial pathogenicity. Nat Rev Microbiol 2:363–378 [CrossRef]
    [Google Scholar]
19. de Bruin O. M., Ludu J. S., Nano F. E. 2007; The Francisella pathogenicity island protein IglA localizes to the bacterial cytoplasm and is needed for intracellular growth. BMC Microbiol 7:1 [CrossRef]
    [Google Scholar]
20. Deng K., Blick R. J., Liu W., Hansen E. J. 2006; Identification of Francisella tularensis genes affected by iron limitation. Infect Immun 74:4224–4236 [CrossRef]
    [Google Scholar]
21. Dennis D. T., Inglesby T. V., Henderson D. A., Bartlett J. G., Ascher M. S., Eitzen E., Fine A. D., Friedlander A. M., Hauer J. other authors 2001; Tularemia as a biological weapon: Medical and Public Health Management. JAMA 285:2763–2773 [CrossRef]
    [Google Scholar]
22. Dorofe'ev K. A. 1947; Classification of the causative agent of tularemia. Symp Res Works Inst Epidemiol Mikrobiol Chita 1:170–180
    [Google Scholar]
23. Ellis J., Oyston P. C. F., Green M., Titball R. W. 2002; Tularemia. Clin Microbiol Rev 15:631–646 [CrossRef]
    [Google Scholar]
24. Evans M. E., Gregory D. W., Schaffner W., McGee Z. A. 1985; Tularemia: a 30 year experience with 88 cases. Medicine (Baltimore) 64:251–269
    [Google Scholar]
25. Farlow J., Wagner D. M., Dukerich M., Stanley M., Chu M., Kubota K., Petersen J., Keim P. 2005; Francisella tularensis i n the United States. Emerg Infect Dis 11:1835–1841 [CrossRef]
    [Google Scholar]
26. Feldman K. A., Enscore R. E., Lathrop S. L., Matyas B. T., McGuill M., Schriefer M. E., Stiles-Enos D., Dennis D. T., Petersen L. R., Hayes E. B. 2001; An outbreak of primary pneumonic tularemia on Martha's Vineyard. N Engl J Med 345:1601–1637 [CrossRef]
    [Google Scholar]
27. Fink S. L., Cookson B. T. 2005; Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 73:1907–1916 [CrossRef]
    [Google Scholar]
28. Forsberg A., Guina T. 2007; Type II secretion and type IV pili of Francisella . Ann N Y Acad Sci 1105187–201 [CrossRef]
    [Google Scholar]
29. Forslund A. L., Kuoppa K., Svensson K., Salomonsson E., Johansson A., Byström M., Oyston P. C. F., Michell S. L., Titball R. W. other authors 2006; Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis . Mol Microbiol 59:1818–1830 [CrossRef]
    [Google Scholar]
30. Forsman M., Sandstrom G., Sjostedt A. 1994; Analysis of 16S ribosomal DNA sequences of Francisella strains and utilization for determination of the phylogeny of the genus and for identification of strains by PCR. Int J Syst Bacteriol 44:38–46 [CrossRef]
    [Google Scholar]
31. Fortier A. H., Green S. J., Polsinelli T., Jones T. R., Crawford R. M., Leiby D. A., Elkins K. L., Meltzer M. S., Nacy C. A. 1994; Life and death of an intracellular pathogen: Francisella tularensis and the macrophage. Immunol Ser 60:349–361
    [Google Scholar]
32. Foshay L. 1950; Tularemia. Annu Rev Microbiol 4:313–330 [CrossRef]
    [Google Scholar]
33. Foshay L., Hesselbrock W. H., Wittenberg H. J., Rodenberg A. H. 1942; Vaccine prophylaxis against tularemia in man. Am J Public Health 32:1131–1145 [CrossRef]
    [Google Scholar]
34. Francis E. 1927; Microscopic changes of tularemia in the tick Dermacentor andersoni and the bedbug Cimex lectularius . Public Health Rep 42:2763–2772 [CrossRef]
    [Google Scholar]
35. Fulop M., Manchee R., Titball R. 1995; Role of lipopolysaccharide and a major outer-membrane protein from Francisella tularensis in the induction of immunity against tularemia. Vaccine 13:1220–1225 [CrossRef]
    [Google Scholar]
36. Fulop M., Mastroeni P., Green M., Titball R. W. 2001; Role of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis . Vaccine 19:4465–4472 [CrossRef]
    [Google Scholar]
37. Gallagher L. A., Ramage E., Jacobst M. A., Kaul R., Brittnacher M., Manoil C. 2007; A comprehensive transposon mutant library of Francisella novicida , a bioweapon surrogate. Proc Natl Acad Sci U S A 104:1009–1014 [CrossRef]
    [Google Scholar]
38. Gil H., Platz G. J., Forestal C. A., Monfett M., Bakshi C. S., Seliati T. J., Furie M. B., Benach J. L., Thanassi D. G. 2006; Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence. Proc Natl Acad Sci U S A 103:12897–12902 [CrossRef]
    [Google Scholar]
39. Golovliov I., Sjostedt A., Mokrievich A., Pavlov V. 2003; A method for allelic replacement in Francisella tularensis . FEMS Microbiol Lett 222:273–280 [CrossRef]
    [Google Scholar]
40. Gray C. G., Cowley S. C., Cheung K. K. M., Nano F. E. 2002; The identification of five genetic loci of Francisella novicida associated with intracellular growth. FEMS Microbiol Lett 215:53–56 [CrossRef]
    [Google Scholar]
41. Hager A. J., Bolton D. L., Pelletier M. R., Brittnacher M. J., Gallagher L. A., Kaul R., Skerrett S. J., Miller S. I., Guina T. 2006; Type IV pili-mediated secretion modulates Francisella virulence. Mol Microbiol 62:227–237 [CrossRef]
    [Google Scholar]
42. Hajjar A. M., Harvey M. D., Shaffer S. A., Goodlett D. R., Sjostedt A., Edebro H., Forsman M., Bystrom M., Pelletier M. other authors 2006; Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect Immun 74:6730–6738 [CrossRef]
    [Google Scholar]
43. Helvaci S., Gedikoglu S., Akalin H., Oral H. B. 2000; Tularemia in Bursa, Turkey: 205 cases in ten years. Eur J Epidemiol 16:271–276 [CrossRef]
    [Google Scholar]
44. Hood A. M. 1977; Virulence factors of Francisella tularensis . J Hyg (Lond) 79:47–65 [CrossRef]
    [Google Scholar]
45. Johansson A., Ibrahim A., Goransson I., Eriksson U., Gurycova D., Clarridge J. E. III, Sjostedt A. 2000; Evaluation of PCR-based methods for discrimination of Francisella species and subspecies and development of a specific PCR that distinguishes the two major subspecies of Francisella tularensis . J Clin Microbiol 38:4180–4185
    [Google Scholar]
46. Johansson A., Berglund L., Sjostedt A., Tarnvik A. 2001; Ciprofloxacin for treatment of tularemia. Clin Infect Dis 33:267–268
    [Google Scholar]
47. Johansson A., Farlow J., Larsson P., Dukerich M., Chambers E., Bystrom M., Fox J., Chu M., Forsman M. other authors 2004; Worldwide genetic relationships among Francisella tularensis isolates determined by multiple-locus variable-number tandem repeat analysis. J Bacteriol 186:5808–5818 [CrossRef]
    [Google Scholar]
48. Kadull P. J., Reames H. R., Coriell L. L., Foshay L. 1950; Studies on tularemia. V. Immunisation of man. J Immunol 65:425–435
    [Google Scholar]
49. Kavanaugh C. N. 1935; Tularemia. A consideration of one hundred and twenty-three cases, with observations at autopsy in one. Arch Intern Med 55:61–85 [CrossRef]
    [Google Scholar]
50. Kawula T. H., Hall J. D., Fuller J. R., Craven R. R. 2004; Use of transposon-transposase complexes to create stable insertion mutant strains of Francisella tularensis LVS. Appl Environ Microbiol 70:6901–6904 [CrossRef]
    [Google Scholar]
51. Keim P., Johansson A., Wagner D. M. 2007; Molecular epidemiology, evolution, and ecology of Francisella . Ann N Y Acad Sci 110530–66 [CrossRef]
    [Google Scholar]
52. Lai X. H., Golovliov I., Sjostedt A. 2001; Francisella tularensis induces cytopathogenicity and apoptosis in murine macrophages via a mechanism that requires intracellular bacterial multiplication. Infect Immun 69:4691–4694 [CrossRef]
    [Google Scholar]
53. Lai X. H., Golovliov I., Sjostedt A. 2004; Expression of IglC is necessary for intracellular growth and induction of apoptosis in murine macrophages by Francisella tularensis . Microb Pathog 37:225–230 [CrossRef]
    [Google Scholar]
54. Larsson P., Oyston P. C. F., Chain P., Chu M., Duffield M. L., Gabbert N. M., Fuxelius H. H., Garcia E., Halltorp G. other authors 2005; The complete genome sequence of Francisella tularensis , the causative agent of tularemia. Nat Genet 37:153–159 [CrossRef]
    [Google Scholar]
55. Lauriano C. M., Barker J. R., Nano F. E., Arulanandarn B. P., Klose K. E. 2003; Allelic exchange in Francisella tularensis using PCR products. FEMS Microbiol Lett 229:195–202 [CrossRef]
    [Google Scholar]
56. Lauriano C. M., Barker J. R., Yoon S. S., Nano F. E., Arulanandam B. P., Hassettt D. J., Klose K. E. 2004; MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival. Proc Natl Acad Sci U S A 101:4246–4249 [CrossRef]
    [Google Scholar]
57. Lee B. Y., Horwitz M. A., Clemens D. L. 2006; Identification, recombinant expression, immuno localization in macrophages, and T-cell responsiveness of the major extracellular proteins of Francisella tularensis . Infect Immun 74:4002–4013 [CrossRef]
    [Google Scholar]
58. Levesque B., de Serres G., Higgins R., D'Halewyn M. A., Atsorb H., Grondin J., Major M., Garvie M., Duval B. 1995; Seroepidemiologic study of three zoonoses (leptospirosis, Q fever, and tularemia) among trappers in Québec, Canada. Clin Diagn Lab Immunol 2:496–498
    [Google Scholar]
59. Lindemann S. R., McLendon M. K., Apicella M. A., Jones B. D. 2007; An in vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells. Infect Immun 75:3178–3182 [CrossRef]
    [Google Scholar]
60. LoVullo E. D., Sherrill L. A., Perez L. L., Pavelka M. S. 2006; Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis . Microbiology 152:3425–3435 [CrossRef]
    [Google Scholar]
61. Maier T. M., Havig A., Casey M., Nano F. E., Frank D. W., Zahrt T. C. 2004; Construction and characterisation of a highly efficient Francisella shuttle plasmid. Appl Environ Microbiol 70:7511–7519 [CrossRef]
    [Google Scholar]
62. Maier T. M., Pechous R., Casey M., Zahrt T. C., Frank D. W. 2006; In vivo Himar1-based transposon mutagenesis of Francisella tularensis . Appl Environ Microbiol 72:1878–1885 [CrossRef]
    [Google Scholar]
63. Maier T. M., Casey M., Becker R., Dorsey C., Glass E., Maltsev N., Zahrt T. C., Frank D. W. 2007; Identification of Francisella tularensis Himar1 -based transposon mutants defective for replication in macrophages. Infect Immun 75:5376–5389 [CrossRef]
    [Google Scholar]
64. Malik M., Bakshi C. S., Sahay B., Shah A., Lotz S. A., Sellati T. J. 2006; Toll-like receptor 2 is required for control of pulmonary infection with Francisella tularensis . Infect Immun 74:3657–3662 [CrossRef]
    [Google Scholar]
65. Malik M., Bakshi C. S., McCabe K., Catlett S. V., Shah A., Singh R., Jackson P. L., Gaggar A., Metzger D. W. other authors 2007; Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensis . J Immunol 178:1013–1020 [CrossRef]
    [Google Scholar]
66. Mariathasan S., Weiss D. S., Dixit V. M., Monack D. M. 2005; Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J Exp Med 202:1043–1049 [CrossRef]
    [Google Scholar]
67. Matyas B. T., Nieder H. S., Telford S. R. III 2007; Pneumonic tularemia on Martha's Vineyard - clinical, epidemiologic, and ecological characteristics. Ann N Y Acad Sci 1105351–377 [CrossRef]
    [Google Scholar]
68. McCaffrey R. L., Allen L.-A. H. 2006; Pivotal advance: Francisella tularensis LVS evades killing by human neutrophils via inhibition of the respiratory burst and phagosome escape. J Leukoc Biol 80:1224–1230 [CrossRef]
    [Google Scholar]
69. McCoy G. W., Chapin C. W. 1912; Further observations on a plague-like disease of rodents with a preliminary note on the causative agent, Bacterium tularense . J Infect Dis 10:61–72 [CrossRef]
    [Google Scholar]
70. McCrumb F. R. 1961; Aerosol infection of man with Pasteurella tularensis . Bacteriol Rev 25:262–267
    [Google Scholar]
71. Mecsas J., Bilis I., Falkow S. 2001; Identification of attenuated Yersinia pseudotuberculosis strains and characterization of an orogastric infection in BALB/c mice on day 5 postinfection by signature-tagged mutagenesis. Infect Immun 69:2779–2787 [CrossRef]
    [Google Scholar]
72. Milne T. S., Michell S. L., Diaper H., Wikstrom P., Svensson K., Oyston P. C. F., Titball R. W. 2007; A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subsp. novicida U112. J Med Microbiol 56:1268–1276 [CrossRef]
    [Google Scholar]
73. Mohapatra N. P., Balagopal A., Soni S., Schlesinger L. S., Gunn J. S. 2007; AcpA is a Francisella acid phosphatase that affects intramacrophage survival and virulence. Infect Immun 75:390–396 [CrossRef]
    [Google Scholar]
74. Mörner T. 1992; The ecology of tularemia. Rev Sci Tech 11:1123–1130
    [Google Scholar]
75. Mougous J. D., Cuff M. E., Raunser S., Shen A., Zhou M., Gifford C. A., Goodman A. L., Joachimiak G., Ordonez C. L. other authors 2006; A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science 312:1526–1530 [CrossRef]
    [Google Scholar]
76. Nano F. E., Zhang N., Cowley S. C., Klose K. E., Cheung K. K. M., Roberts M. J., Ludu J. S., Letendre G. W., Meierovics A. I. other authors 2004; A Francisella tularensis pathogenicity island required for intramacrophage growth. J Bacteriol 186:6430–6436 [CrossRef]
    [Google Scholar]
77. Nylund A., Ottem K. F., Watanabe K., Karlsbakk E., Krossoy B. 2006; Francisella sp (family Francisellaceae ) causing mortality in Norwegian cod ( Gadus morhua ) farming. Arch Microbiol 185:383–392 [CrossRef]
    [Google Scholar]
78. Ohara Y., Sato T., Fujita H., Ueno T., Homma M. 1991; Clinical manifestations of tularemia in Japan - analysis of 1355 cases observed between 1924 and 1987. Infection 19:14–17 [CrossRef]
    [Google Scholar]
79. Ostland V. E., Stannard J. A., Creek J. J., Hedrick R. P., Ferguson H. W., Carlberg J. M., Westerman M. E. 2006; Aquatic Francisella -like bacterium associated with mortality of intensively cultured hybrid striped bass Morone chrysops × M. saxatilis . Dis Aquat Organ 72:135–145 [CrossRef]
    [Google Scholar]
80. Oyston P. C. F., Sjostedt A., Titball R. W. 2004; Tularemia: bioterrorism defence renews interest in Francisella tularensis . Nat Rev Microbiol 2:967–978 [CrossRef]
    [Google Scholar]
81. Petrosino J. F., Xiang Q., Karpathy S. E., Jiang H. Y., Yerrapragada S., Liu Y. M., Gioia J., Hemphill L., Gonzalez A. other authors 2006; Chromosome rearrangement and diversification of Francisella tularensis revealed by the type B (OSU18) genome sequence. J Bacteriol 188:6977–6985 [CrossRef]
    [Google Scholar]
82. Phillips N. J., Schilling B., McLendon M. K., Apicella M. A., Gibson B. W. 2004; Novel modification of lipid A of Francisella tularensis . Infect Immun 72:5340–5348 [CrossRef]
    [Google Scholar]
83. Prior J. L., Prior R. G., Hitchen P. G., Diaper H., Griffin K. F., Morris H. R., Dell A., Titball R. W. 2003; Characterization of the O antigen gene cluster and structural analysis of the O antigen of Francisella tularensis subsp. tularensis . J Med Microbiol 52:845–851 [CrossRef]
    [Google Scholar]
84. Pukatzki S., Ma A. T., Sturtevant D., Krastins B., Sarracino D., Nelson W. C., Heidelberg J. F., Mekalanos J. J. 2006; Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci U S A 103:1528–1533 [CrossRef]
    [Google Scholar]
85. Qin A., Mann B. J. 2006; Identification of transposon insertion mutants of Francisella tularensis tularensis strain Schu S4 deficient in intracellular replication in the hepatic cell line HepG2. BMC Microbiol 6:69 [CrossRef]
    [Google Scholar]
86. Rahhal R. M., Bush T. J. V., McLendon M. K., Apicella M. A., Bishop G. A. 2007; Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes. J Leukoc Biol 82:813–820 [CrossRef]
    [Google Scholar]
87. Rasko D. A., Esteban C. D., Sperandio V. 2007; Development of novel plasmid vectors and a promoter trap system in Francisella tularensis compatible with the pFLN10 based plasmids. Plasmid 58:159–166 [CrossRef]
    [Google Scholar]
88. Raynaud C., Meibom K. L., Lety M. A., Dubail I., Candela T., Frapy E., Charbit A. 2007; Role of the wbt locus of Francisella tularensis in lipopolysaccharide O-antigen biogenesis and pathogenicity. Infect Immun 75:536–541 [CrossRef]
    [Google Scholar]
89. Reilly T. J., Baron G. S., Nano F. E., Kuhlenschmidt M. S. 1996; Characterization and sequencing of a respiratory burst-inhibiting acid phosphatase from Francisella tularensis . J Biol Chem 271:10973–10983 [CrossRef]
    [Google Scholar]
90. Rohmer L., Brittnacher M., Svensson K., Buckley D., Haugen E., Zhou Y., Chang J., Levy R., Hayden H. other authors 2006; Potential source of Francisella tularensis live vaccine strain attenuation determined by genome comparison. Infect Immun 74:6895–6906 [CrossRef]
    [Google Scholar]
91. Sandstrom G., Sjostedt A., Johansson T., Kuoppa K., Williams J. C. 1992; Immunogenicity and toxicity of lipopolysaccharide from Francisella tularensis LVS. FEMS Microbiol Immunol 5:201–210
    [Google Scholar]
92. Santic M., Molmeret M., Barker J. R., Klose K. E., Dekanic A., Doric M., Abu Kwaik Y. 2007; A Francisella tularensis pathogenicity island protein essential for bacterial proliferation within the host cell cytosol. Cell Microbiol 9:2391–2403 [CrossRef]
    [Google Scholar]
93. Santic M., Asare R., Skrobonja I., Jones S., Kwaik Y. A. 2008; Acquisition of the vATPase proton pump and phagosome acidification is essential for escape of Francisella tularensis into the macrophage cytosol. Infect Immun in press
    [Google Scholar]
94. Shen H., Chen W. X., Conlan J. W. 2004; Mice sublethally infected with Francisella novicida U112 develop only marginal protective immunity against systemic or aerosol challenge with virulent type A or B strains of F. tularensis . Microb Pathog 37:107–110 [CrossRef]
    [Google Scholar]
95. Shepard C. C. 1959; Nonacid-fast bacteria and HeLa cells: their uptake and subsequent intracellular growth. J Bacteriol 77:701–714
    [Google Scholar]
96. Sjostedt A. 2005; Family XVII. Francisellaceae , genus I. Francisella . . In Bergey's Manual of Systematic Bacteriology pp 200–210 Edited by Brenner D. J., Krieg N. R., Staley J. T., Garrity G. M. New York: Springer;
    [Google Scholar]
97. Sjostedt A. 2007; Tularemia: history, epidemiology, pathogen physiology, and clinical manifestations. Ann N Y Acad Sci 11051–29 [CrossRef]
    [Google Scholar]
98. Staples J. E., Kubota K. A., Chalcraft L. G., Mead P. S., Petersen J. M. 2006; Epidemiologic and molecular analysis of human tularemia, United States, 1964–2004. Emerg Infect Dis 12:1113–1118 [CrossRef]
    [Google Scholar]
99. Steinemann T. L., Sheikholeslami M. R., Brown H. H., Bradsher R. W. 1999; Oculoglandular tularemia. Arch Ophthalmol 117:132–133 [CrossRef]
    [Google Scholar]
100. Stewart S. J. 1996; Tularemia: association with hunting and farming. FEMS Immunol Med Microbiol 13:197–199 [CrossRef]
     [Google Scholar]
101. Stover C. K., Pham X. Q., Erwin A. L., Mizoguchi S. D., Warrener P., Hickey M. J., Brinkman F. S. L., Hufnagle W. O., Kowalik D. J. other authors 2000; Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature 406:959–964 [CrossRef]
     [Google Scholar]
102. Su J., Yang J., Zhao D., Kawula T. H., Banas J. A., Zhang J.-R. 2007; Genome-wide identification of Francisella tularensis virulence determinants. Infect Immun 75:3089–3101 [CrossRef]
     [Google Scholar]
103. Syrjala H., Kujala P., Myllyla V., Salminen A. 1985; Airborne transmission of tularemia in farmers. Scand J Infect Dis 17:371–375
     [Google Scholar]
104. Syrjala H., Schildt R., Raisainen S. 1991; In vitro susceptibility of Francisella tularensis to fluoroquinolones and treatment of tularemia with norfloxacin and ciprofloxacin. Eur J Clin Microbiol Infect Dis 10:68–70 [CrossRef]
     [Google Scholar]
105. Tarnvik A. 1989; Nature of protective immunity to Francisella tularensis . Rev Infect Dis 11:440–451 [CrossRef]
     [Google Scholar]
106. Tarnvik A., Chu M. C. 2007; New approaches to diagnosis and therapy of tularemia. Ann N Y Acad Sci 1105378–404 [CrossRef]
     [Google Scholar]
107. Tarnvik A., Sandstrom G., Sjostedt A. 1996; Epidemiological analysis of tularemia in Sweden 1931–1993. FEMS Immunol Med Microbiol 13:201–204
     [Google Scholar]
108. Telepnev M., Golovliov I., Grundstrom T., Tarnvik A., Sjostedt A. 2003; Francisella tularensis inhibits Toll-like receptor-mediated activation of intracellular signalling and secretion of TNF- α and IL-1 from murine macrophages. Cell Microbiol 5:41–51 [CrossRef]
     [Google Scholar]
109. Tempel R., Lai X. H., Crosa L., Kozlowicz B., Heffron F. 2006; Attenuated Francisella novicida transposon mutants protect mice against wild-type challenge. Infect Immun 74:5095–5105 [CrossRef]
     [Google Scholar]
110. Thakran S., Li H., Lavine C. L., Miller M. A., Bina J. E., Bina X. R., Re F. 2007; Identification of Francisella tularensis lipoproteins that stimulate the Toll-like receptor (TLR) 2/TLR1 heterodimer. J Biol Chem 283:3751–3760
     [Google Scholar]
111. Thomas R. M., Titball R. W., Oyston P. C. F., Griffin K., Waters E., Hitchen P. G., Michell S. L., Grice I. D., Wilson J. C., Prior J. L. 2007; The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens. Infect Immun 75:371–378 [CrossRef]
     [Google Scholar]
112. Titball R. W., Petrosino J. F. 2007; Francisella tularensis genomics and proteomics. Ann N Y Acad Sci 110598–121 [CrossRef]
     [Google Scholar]
113. Titball R. W., Sjostedt A., Pavelka M. S. Jr, Nano F. E. 2007; Biosafety and selectable markers. Francisella tularensis : biology, pathogenicity, epidemiology, and biodefense. Ann N Y Acad Sci 1105405–417 [CrossRef]
     [Google Scholar]
114. Twine S., Bystrom M., Chen W. X., Forsman M., Golovliov I., Johansson A., Kelly J., Lindgren H., Svensson K. other authors 2005; A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine. Infect Immun 73:8345–8352 [CrossRef]
     [Google Scholar]
115. Vinogradov E., Perry M. B., Conlan J. W. 2002; Structural analysis of Francisella tularensis lipopolysaccharide. Eur J Biochem 269:6112–6118 [CrossRef]
     [Google Scholar]
116. Vinogradov E., Conlan W., Gunn J. S., Perry M. B. 2004; Characterisation of the lipopolysaccharide O-antigen of Francisella novicida . Carbohydr Res 339:649–654 [CrossRef]
     [Google Scholar]
117. Wang X., Ribeiro A. A., Guan Z., McGrath S. C., Cotter R. J., Raetz C. R. H. 2006; Structure and biosynthesis of free lipid A molecules that replace lipopolysaccharide in Francisella tularensis subsp. novicida . Biochemistry 45:14427–14440 [CrossRef]
     [Google Scholar]
118. Weiss D. S., Brotcke A., Henry T., Margolis J. J., Chan K., Monack D. M. 2007; In vivo negative selection screen identifies genes required for Francisella virulence. Proc Natl Acad Sci U S A 104:6037–6042 [CrossRef]
     [Google Scholar]
119. Whipp M. J., Davis J. M., Lum G., de Boer J., Zhou Y., Bearden S. W., Petersen J. M., Chu M. C., Hogg G. 2003; Characterization of a novicida -like subspecies of Francisella tularensis isolated in Australia. J Med Microbiol 52:839–842 [CrossRef]
     [Google Scholar]