MYC and the Control of DNA Replication

  1. Jean Gautier1,2
  1. 1Institute for Cancer Genetics, Columbia University, New York, New York 10032
  2. 2Department of Genetics and Development, Columbia University, New York, New York 10032
  1. Correspondence: jg130{at}columbia.edu

  • ↵3 Present address: Department of Oncological Sciences & Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Abstract

The MYC oncogene is a multifunctional protein that is aberrantly expressed in a significant fraction of tumors from diverse tissue origins. Because of its multifunctional nature, it has been difficult to delineate the exact contributions of MYC’s diverse roles to tumorigenesis. Here, we review the normal role of MYC in regulating DNA replication as well as its ability to generate DNA replication stress when overexpressed. Finally, we discuss the possible mechanisms by which replication stress induced by aberrant MYC expression could contribute to genomic instability and cancer.

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    1. doi: 10.1101/cshperspect.a014423 Cold Spring Harb Perspect Med 4: Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved
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