Psoriasis
- 1Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
- 2St. John's Institute of Dermatology, King's College London, London SE1 9RT, United Kingdom
- 3National Institute for Health Research GSTT/KCL Comprehensive Biomedical Research Centre, Guy's and St. Thomas' National Health Service Foundation Trust, London SE1 9RT, United Kingdom
- Correspondence: frank.nestle{at}kcl.ac.uk
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↵4 These authors contributed equally to this work.
Abstract
Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes and results from the interplay of genetic, environmental, and immunological factors. Four decades of clinical and basic research on psoriasis have elucidated many of the pathogenic mechanisms underlying disease and paved the way to effective targeted therapies. Here, we review this progress and identify future directions of study that are supported by a more integrative research approach and aim at further improving the patients' life.
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