The Enigma of p53
- Correspondence: gglozano{at}mdanderson.org
Abstract
This perspective will focus on the physiological impact of wild-type and mutant p53 activities. In particular, the tissue-specific nature of activation of p53 targets and their subsequent effects on cell behavior will be discussed. Because mutations in p53 are common in human cancers, the regulation and physiological consequences of mutant p53 proteins will also be discussed.
- © 2016 Lozano; Published by Cold Spring Harbor Laboratory Press
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