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Sustained drug delivery optimizes long-term treatment of patients with schizophrenia

Published online by Cambridge University Press:  24 June 2014

Pierre S. Chue ,
Peter D'Hoore  and
J. Michael Ramstack
Pierre S. Chue*
Affiliation:
Department of Psychiatry, University of Alberta Hospital, Alberta, Canada
Peter D'Hoore
Affiliation:
Johnson & Johnson Pharmaceutical Research and Development, Beerse, Belgium
J. Michael Ramstack
Affiliation:
Alkermes, Inc, Cambridge, MA, USA
*
Dr Pierre Chue, 3rd Floor, 9942-108 Street, Edmonton, Alberta, Canada. Tel: +1 780 428 1776; Fax: +1 780 425 9317; E-mail: pchue@ualberta.ca
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Abstract

Chronic disorders such as schizophrenia require long-term treatment programs in order to maintain patients at the lowest level of symptomatology, reduce the likelihood of psychotic relapse, and support achievement of remission and recovery. Evidence suggests that treatment with long-acting injectable antipsychotics reduces the impact of partial compliance and provides predictable release of medication, assuring continuous therapeutic coverage. Until recently, only conventional antipsychotic agents were available in long-acting formulations, thereby foregoing the advantages of the atypical class. Atypical agents which are given orally have been shown to provide long-term efficacy and tolerability benefits compared with conventional agents, but are limited by the need for daily administration. The most recent pharmacological strategy to achieve optimal maintenance treatment has been to combine the benefits of an atypical antipsychotic with delivery in a water-based long-acting formulation. The first antipsychotic to achieve this combination – long-acting risperidone – may thus represent an important advance in the optimization of long-term treatment outcomes in patients with schizophrenia.

Keywords

antipsychoticcompliancelong actingmaintenancetolerability
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 16 , Issue 6 , December 2004 , pp. 319 - 325
Copyright
Copyright © 2004 Blackwell Munksgaard

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