Essentials
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Annexin A5 resistance is a mechanism for antiphospholipid (aPL) syndrome.
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750 patients with history of thrombosis, pregnancy complications and controls were tested.
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Reduced annexin A5 anticoagulant ratios (A5R) correlate with aPL antibody multipositivity.
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Reduced A5R may identify patients with a propensity for thrombosis or pregnancy complications.