Optical dosimetry in photodynamic therapy: determination of the effective penetration depth of light in tissue according to measurements in backscattering models

Charles Abdul-Nour; Laure Muller; Yves Granjon; Francois H. Guillemin; Edouard Yvroud

doi:10.1117/12.199188

18 January 1995 Optical dosimetry in photodynamic therapy: determination of the effective penetration depth of light in tissue according to measurements in backscattering models

Charles Abdul-Nour, Laure Muller, Yves Granjon, Francois H. Guillemin, Edouard Yvroud

Author Affiliations +

Proceedings Volume 2323, Laser Interaction with Hard and Soft Tissue II; (1995) https://doi.org/10.1117/12.199188
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The extent of tumor necrosis can be determined by the knowledge of the penetration depth of the light through tissue. So, we must determine the effective penetration depth `(delta) ' during treatment, depth at which the incident light intensity is reduced to 36.6%. Light transmission measurements through tissues is the experimental model usually used as a reference method to estimate the value of (delta) . In order to achieve subsequently on line and in situ light dosimetry during PDT, light backscattering has been studied in different concentrations of blue ink and intralipid-20%. All parameters which would influence the value of the back-attenuation coefficient (Sigma) _ba have been reviewed separately. The results of transmission and backscattering measurements are compared. A correlation function `R' between (Sigma) _eff and (Sigma) _ba can be deduced, the knowledge of R allows us to determine the effective light penetration depth in tissue through backscattering measurement.

Citation Download Citation

Charles Abdul-Nour, Laure Muller, Yves Granjon, Francois H. Guillemin, and Edouard Yvroud "Optical dosimetry in photodynamic therapy: determination of the effective penetration depth of light in tissue according to measurements in backscattering models", Proc. SPIE 2323, Laser Interaction with Hard and Soft Tissue II, (18 January 1995); https://doi.org/10.1117/12.199188

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