Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells

Chi K. Chang; Pak-Wing Kong; Hai-Yang Liu; Lam-Lung Yeung; Ho-Kee Koon; Nai-Ki Mak

doi:10.1117/12.646328

6 March 2006 Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells

Chi K. Chang, Pak-Wing Kong, Hai-Yang Liu, Lam-Lung Yeung, Ho-Kee Koon, Nai-Ki Mak

Proceedings Volume 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV; 613915 (2006) https://doi.org/10.1117/12.646328
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Ten trans-A2B and A3-type corrole photosensitizers carrying functional groups were synthesized and screened for PDT activities. Photocytotoxicity was measured by the MTT cell reduction assay on a cultured human nasopharyngeal carcinoma (NPC) cell line (HONE-1). Experimental results indicated that corroles containing a single hydroxyphenyl substituent (3, 4 and 5) exhibit the highest activity among the corrole derivatives investigated. Confocal microscopy revealed that the site of cellular localization of the photosensitizers is predominantly at mitochondria. Also, nuclear staining detected apoptotic cell death.

Citation Download Citation

Chi K. Chang, Pak-Wing Kong, Hai-Yang Liu, Lam-Lung Yeung, Ho-Kee Koon, and Nai-Ki Mak "Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells", Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 613915 (6 March 2006); https://doi.org/10.1117/12.646328

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