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Transcription-controlling regulatory elements of the eukaryotic genome

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Abstract

The eukaryotic genomic regulatory elements that control transcription are considered. The review describes the functional anatomy of tissue-specific and housekeeping gene promoters, current methods to predict and to identify the enhancers, and the role insulators play in enhancer-promoter communication and maintenance of the epigenetic status of genome domains. The relationship between the topology of interphase chromatin and the regulation of transcription is outlined. Particular attention is paid to recent data obtained via high-throughput sequencing of primary transcripts and genome-wide analysis of histone modifications.

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Abbreviations

BREd:

downstream TFIIB recognition element

BREu:

upstream TFIIB recognition element

DPE:

downstream promoter element

DRE:

DNA replication-related element

Inr:

transcription initiator

LCR:

locus control region

PRE:

Polycomb response element

TBP:

TATA-binding protein

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Authors and Affiliations

  1. Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    S. V. Razin & S. V. Ulyanov

  2. Department of Molecular Biology, Biological Faculty, Moscow State University, Moscow, 119991, Russia

    S. V. Razin & S. V. Ulyanov

  3. Group of Genome Spatial Organization, Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    A. A. Gavrilov

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Original Russian Text © S.V. Razin, A.A. Gavrilov, S.V. Ulyanov, 2015, published in Molekulyarnaya Biologiya, 2015, Vol. 49, No. 2, pp. 212–223.

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Razin, S.V., Gavrilov, A.A. & Ulyanov, S.V. Transcription-controlling regulatory elements of the eukaryotic genome. Mol Biol 49, 185–194 (2015). https://doi.org/10.1134/S0026893315020119

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