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Structure and permeability changes of the blood-brain barrier in APP/PS1 mice: an Alzheimer’s disease animal model

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Abstract

The present work explored the blood-brain barrier (BBB) changes in a mice model of Alzheimer’s disease (AD) (APP/PS1 double mutant). The transgenic mice model showed overexpression of Aβ1–42 in the brain and the loss of learning functions. The test with tail vein injection of Evans Blue (EB) showed more EB fluorescence in the brain tissue, suggesting an increased BBB permeability. Additionally, Electronic microscope (EM) images showed changes in base membrane, vessel-associated glial cells, pericytes, and endothelial cells. This work supported the BBB dysfunction hypothesis in AD, and suggested that APP/PS1 mice could be a suitable model in testing BBB-crossing drugs of AD.

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Authors and Affiliations

  1. Department of Neurology, The first affiliated hospital, China Medical University, Shen Yang, China, 110001

    Yulin Wang, Jing Liu & Chaodong Zhang

  2. Department of Neurology, Hong Qi Hospital, Mu Dan Jiang Medical College, Mu Dan Jiang, China

    Zhongmin Zhang

  3. Department of Aging diseases, The second affiliated hospital, Mu Dan Jiang Medical College, Mu Dan Jiang, China

    Xiaoli Wang

Authors
  1. Yulin Wang
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  2. Jing Liu
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  3. Zhongmin Zhang
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  4. Xiaoli Wang
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  5. Chaodong Zhang
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Correspondence to Chaodong Zhang.

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Wang, Y., Liu, J., Zhang, Z. et al. Structure and permeability changes of the blood-brain barrier in APP/PS1 mice: an Alzheimer’s disease animal model. Neurochem. J. 5, 220–222 (2011). https://doi.org/10.1134/S1819712411030135

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  • DOI: https://doi.org/10.1134/S1819712411030135

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