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Community child health, public health, and epidemiology
Efficacy of school urinary screening for membranoproliferative glomerulonephritis type 1
  1. Y Kawasaki,
  2. J Suzuki,
  3. R Nozawa,
  4. H Suzuki
  1. Department of Pediatrics, Fukushima Medical University School of Medicine, Japan
  1. Correspondence to:
    Dr Y Kawasaki, Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima City, Fukushima 960-1295, Japan;
    tomo{at}fmu.ac.jp

Abstract

Aims: In order to evaluate the efficacy of a school urinary screening programme, children with membranoproliferative glomerulonephritis (MPGN) type 1 were studied.

Methods: A total of 52 patients who had been diagnosed with MPGN type 1 from 1970 to 1997 were studied; 35 were identified after 1974 on screening (group S), and 17 were identified by presenting symptoms (group N), mostly before 1989.

Results: Mean blood pressure was 89 mm Hg in group S and 104 mm Hg in group N; urinary protein excretion was 0.9 g/day in group S and 3.0 g/day in group N. Histopathological evidence of chronic changes was found in six group S and 15 group N patients. No patients in group S had renal insufficiency, but five patients in group N required regular haemodialysis.

Conclusions: Results suggest that early identification by school urinary screening may enable early management and so improve prognosis of MPGN.

  • membranoproliferative glomerulonephritis
  • urinary screening
  • school
  • prognosis
  • BUN, blood urea nitrogen
  • EM, electron microscopy
  • IF, immunofluorescence
  • Ig, immunoglobulin
  • LM, light microscopy
  • MD, mesangial deposit
  • MPGN, membranoproliferative glomerulonephritis
  • SEND, subendothelial deposit
  • SEPT, subepithelial deposit
  • SUS, school urinary screening

https://doi.org/10.1136/adc.86.1.21

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