Behçet disease (BD) is a chronic systemic auto-inflammatory immune disorder with generalised vasculitis of the arteries and veins. It was originally described as orogenital aphthous ulcerations and uveitis but the disease can affect any organ or system. BD is characterised by recurrent crises of variable duration and intervals. The skin pathergy reaction (SPR),1 which explores hypersensitivity to minor trauma (needle prick), is considered as one of the main criteria for BD diagnosis, by both the International Study Group (ISG) of BD and the Behçet Disease Japanese Committee.2 In spite of its high specificity, SPR has a variable sensitivity and inconstant reproducibility, which limit its use.

Although the aetiology of the disease is still unknown, …