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Clinical science
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A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis
  1. N V Prajna1,
  2. R K John1,2,
  3. P K Nirmalan1,2,
  4. P Lalitha1,
  5. M Srinivasan1
  1. 1Aravind Eye Care System, Madurai, India
  2. 2Lions Aravind Institute of Community Ophthalmology, Madurai, India
  1. Correspondence to: N Venkatesh Prajna, Cornea Service, Aravind Eye Care System, 1 Anna Nagar, Madurai-625020, India; prajna{at}aravind.org

Abstract

Aim: To compare 2% econazole and 5% natamycin in the management of fungal keratitis.

Methods: A randomised clinical trial was performed using 2% econazole or 5% natamycin as the two treatment arms on patients presenting with culture positive fungal keratitis to the cornea service at Aravind Eye Care System, Madurai, India.

Results: 116 patients were recruited, and 112 continued in the study. There were no significant differences between the two arms at baseline or for success (defined as a healed or healing ulcer) at final visit (p = 0.79).

Conclusions: 2% Econazole appears to be as effective as 5% natamycin for the management of fungal keratitis.

  • fungal keratitis
  • randomised clinical trial
  • econazole
  • natamycin

https://doi.org/10.1136/bjo.87.10.1235

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    Footnotes

    • Financial interest: None