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CDK4/6 inhibitors in the treatment of patients with breast cancer: summary of a multidisciplinary round-table discussion

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ABSTRACT

This article is the result of a round-table discussion organised by ESMO Open in Vienna in December 2017. Its purpose is to discuss the background and advances in the evidence regarding cyclin-dependent kinase 4/6 inhibitors (palbociclib, ribociclib and abemaciclib) in the treatment of metastatic and early-stage breast cancer and to explore what the key open research questions are and next steps should be.

CDK4/6 inhibitors
breast cancer
metastatic breast cancer
endocrine therapy
endocrine resistance
HR-positive breast cancer

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Funding: This initiative was sponsored by Lilly through the provision of an unrestricted educational grant. Lilly has had no influence over the content other than a review of the paper for medical accuracy. The participants/authors received an honorarium for their participation in the round-table from BMJ.

Competing interests: MP: honoraria for lectures, consultation or advisory board participation from the following for-profit companies: Bayer, Bristol-Myers Squibb, Novartis, Gerson Lehrman Group (GLG), CMC Contrast, GlaxoSmithKline, Mundipharma, Roche, Astra Zeneca, AbbVie, Lilly, Medahead, Daiichi Sankyo, Merck Sharp & Dome. MT: advisory role at: Amgen, AstraZeneca, Celgene, Eisai, Genomic Health, Lilly, Neodynamics, Novartis, Pfizer, pfm Medical, Roche, RTI Surgical, SurgicEye, Tesaro, Teva. Speaker engagements and travel support: Amgen, AstraZeneca, Boehringer Ingelheim, Celgene, Eisai, Genomic Health, Medtronic, Myriad, Novartis, Pfizer, pfm Medical, Roche, RTI Surgical, Teva. Manuscript fees: Roche, Celgene. Trial funding: Genomic Health. RB: advisory role: Eli-Lilly, Novartis, Pfizer; Lecture honoraria: Eli-Lilly, Novartis, Pfizer; research support: Novartis; Travel support: Pfizer. TR: advisory role for: Lilly, Roche, Novartis, Pfizer, AstraZeneca; Travel support: Roche, Amgen. EdA: honoraria and advisory board: Roche/GNE; travel grants: Roche/GNE and GSK/Novartis; research grant: Roche/GNE. CZ: honoraria from Roche, Novartis, BMS, MSD, Imugene, Ariad, Pfizer, Merrimack, Merck KGaA, Fibrogen, AstraZeneca, Tesaro, Gilead, Servier, Shire.

Provenance and peer review: Commissioned; externally peer reviewed.