1932

Abstract

Molecular and genetic characterizations of circadian rhythms in indicate that function of an intracellular pacemaker requires the activities of proteins encoded by three genes: (), (), and (). RNA from two of these genes, and , is expressed with a circadian rhythm. Heterodimerization of PER and TIM proteins allows nuclear localization and suppression of further RNA synthesis by a PER/TIM complex. These protein interactions promote cyclical gene expression because heterodimers are observed only at high concentrations of, and RNA, separating intervals of RNA accumulation from times of PER/TIM complex activity. Light resets these molecular cycles by eliminating TIM. The product of also regulates accumulation of and RNA, and it may influence action of the PER/TIM complex. The recent discovery of PER homologues in mice and humans suggests that a related mechanism controls mammalian circadian behavioral rhythms.

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/content/journals/10.1146/annurev.biochem.67.1.135
1998-07-01
2024-03-28
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