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Fisher Syndrome and Bickerstaff Brainstem Encephalitis Satoshi Kuwabara 1 1Department of Neurology, Graduate School of Medicine, Chiba University Keyword: フィッシャー症候群 , ビッカースタッフ脳幹脳炎 , ガングリオシドGQ1b , 抗GQ1b抗体 , 分子相同性 , Fisher syndrome , Bickerstaff brainstem encephalitis , ganglioside GQ1b , molecular mimicry , immune-mediated neuropathy pp.1371-1376
Published Date 2015/11/1
DOI https://doi.org/10.11477/mf.1416200308
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Abstract

Fisher syndrome has been regarded as a peculiar inflammatory neuropathy with ophthalmoplegia, ataxia, and areflexia, whereas Bickerstaff brainstem encephalitis has been considered a pure central nervous system disease characterized by ophthalmoplegia, ataxia, and consciousness disturbance. Both disorders share common features including preceding infection, albumin-cytological dissociation, and association with Guillain-Barré syndrome. The discovery of anti-GQ1b IgG antibodies further supports the view that the two disorders represent a single disease spectrum. The lesions in Fisher syndrome and Bickerstaff brainstem encephalitis are presumably determined by the expression of ganglioside GQ1b in the human peripheral and central nervous systems. Bickerstaff brainstem encephalitis is likely to represent a variant of Fisher syndrome with central nervous system involvement.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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