Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks

Toy, Bülent; Tarçın, Orhan; Bağcı, Sait; Üstündağ, Yücel; Inal, Ali; Tiftikçi, Arzu

doi:https://doi.org/10.1155/MI/2006/62868

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 062868 | https://doi.org/10.1155/MI/2006/62868

Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks

Bülent Toy,¹Orhan Tarçın,^2,3Sait Bağcı,¹Yücel Üstündağ,⁴Ali Inal,⁵and Arzu Tiftikçi⁶

Received20 Jul 2005

Accepted17 Nov 2005

Published09 Mar 2006

Abstract

The aim of our study is to determine whether there is a relationship between familial Mediterranean fever (FMF) attacks and serum leptin levels. We enrolled 25 patients (22 males and 3 females) and 25 healthy controls (21 males and 4 females) with a mean age of 24.42±1.22 (Mean ± SEM) years and 24.30±1.19 years (Mean ± SEM), respectively. We investigated serum levels of leptin, interleukin-6 (IL-6) erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fibrinogen, and leukocyte counts before the attack and 8–12 hours after the attack started. The same parameters have been investigated in the control subjects. The mean serum leptin levels before the attacks were 6.45±1.05 (Mean ± SEM) and during the attacks were 7.59±1.3 (Mean ± SEM) in FMF group, respectively. There was a slight increase in serum leptin levels during the attacks but it was not statistically significant (P>.05). The mean serum leptin levels were 6.12±2.81 in the control group which were not different from the mean serum leptin levels before and during the attack periods in the study group (P>.05). However, there were statistical differences in the serum levels of IL-6, ESR, CRP, fibrinogen, and leukocyte counts before and during the attack periods (P<.05). No correlation was found between serum leptin levels and IL-6, ESR, CRP, fibrinogen, and leukocyte counts (P>.05). Serum leptin levels do not increase during FMF attacks and therefore it is not useful for diagnostic purposes and follow-up during treatment.

References

N Gang, J P Drenth, P Langevitz et al., “Activation of the cytokine network in familial Mediterranean fever,” The Journal of Rheumatology, vol. 26, no. 4, pp. 890–897, 1999.
View at: Google Scholar
E Sohar, J Gafni, M Pras, and H Heller, “Familial Mediterranean fever. A survey of 470 cases and review of the literature,” The American Journal of Medicine, vol. 43, no. 2, pp. 227–253, 1967.
View at: Google Scholar
I Touitou, E Ben-Chetrit, C Notarnicola et al., “Familial Mediterranean fever clinical and genetic features in Druzes and in Iraqi Jews: a preliminary study,” The Journal of Rheumatology, vol. 25, no. 5, pp. 916–919, 1998.
View at: Google Scholar
S Kiraz, I Ertenli, M Arici et al., “Effects of colchicine on inflammatory cytokines and selectins in familial Mediterranean fever,” Clinical and Experimental Rheumatology, vol. 16, no. 6, pp. 721–724, 1998.
View at: Google Scholar
Y Baykal, K Saglam, M I Yilmaz, A Taslipinar, S B Akinci, and A Inal, “Serum sIL-2r, IL-6, IL-10 and TNF-alpha level in familial Mediterranean fever patients,” Clinical Rheumatology, vol. 22, no. 2, pp. 99–101, 2003.
View at: Google Scholar
C Notarnicola, M N Didelot, F Seguret, J Demaille, and I Touitou, “Enhanced cytokine mRNA levels in attack-free patients with familial Mediterranean fever,” Genes & Immunity, vol. 3, no. 1, pp. 43–45, 2002.
View at: Google Scholar
L A Campfield, F J Smith, Y Guisez, R Devos, and P Burn, “Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks,” Science, vol. 269, no. 5223, pp. 546–549, 1995.
View at: Google Scholar
J L Halaas, K S Gajiwala, M Maffei et al., “Weight-reducing effects of the plasma protein encoded by the obese gene,” Science, vol. 269, no. 5223, pp. 543–546, 1995.
View at: Google Scholar
M Barbier, C Cherbut, A C Aubé, H M Blottière, and J P Galmiche, “Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats,” Gut, vol. 43, no. 6, pp. 783–790, 1998.
View at: Google Scholar
J E Jr Darnell, I M Kerr, and G R Stark, “Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins,” Science, vol. 264, no. 5164, pp. 1415–1421, 1994.
View at: Google Scholar
R Faggioni, K R Feingold, and C Grunfeld, “Leptin regulation of the immune response and the immunodeficiency of malnutrition,” The FASEB Journal, vol. 15, no. 14, pp. 2565–2571, 2001.
View at: Google Scholar
J F Caro, M K Sinha, J W Kolaczynski, P L Zhang, and R V Considine, “Leptin: the tale of an obesity gene,” Diabetes, vol. 45, no. 11, pp. 1455–1462, 1996.
View at: Google Scholar
V Mohamed-Ali, S Goodrick, A Rawesh et al., “Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor- $\alpha$ , in vivo,” The Journal of Clinical Endocrinology & Metabolism, vol. 82, no. 12, pp. 4196–4200, 1997.
View at: Google Scholar
P Maruna, R Gürlich, R Fraško, and M Haluzík, “Serum leptin levels in septic men correlate well with C-reactive protein (CRP) and TNF-alpha but not with BMI,” Physiological Research, vol. 50, no. 6, pp. 589–594, 2001.
View at: Google Scholar
J-P Bastard, C Jardel, E Bruckert et al., “Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss,” The Journal of Clinical Endocrinology & Metabolism, vol. 85, no. 9, pp. 3338–3342, 2000.
View at: Google Scholar
M Eliakim, M Levy, and M Ehrenfeld, Recurrent Polyserositis: Familial Mediterranean Fever, Periodic Disease, Elsevier/North-Holland Biomedical Press, New York, NY/Amsterdam, The Netherlands, 1981.
View at: Google Scholar
Z Orban, A T Remaley, M Sampson, Z Trajanoski, and G P Chrousos, “The differential effect of food intake and $\beta$ -adrenergic stimulation on adipose-derived hormones and cytokines in man,” The Journal of Clinical Endocrinology & Metabolism, vol. 84, no. 6, pp. 2126–2133, 1999.
View at: Google Scholar
R S Ahima, D Prabakaran, C Mantzoros et al., “Role of leptin in the neuroendocrine response to fasting,” Nature, vol. 382, no. 6588, pp. 250–252, 1996.
View at: Google Scholar
G Boden, X Chen, M Mozzoli, and I Ryan, “Effect of fasting on serum leptin in normal human subjects,” The Journal of Clinical Endocrinology & Metabolism, vol. 81, no. 9, pp. 3419–3423, 1996.
View at: Google Scholar
P Sarraf, R C Frederich, E M Turner et al., “Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia,” The Journal of Experimental Medicine, vol. 185, no. 1, pp. 171–175, 1997.
View at: Google Scholar
M Bulló, P García-Lorda, I Megias, and J Salas-Salvadó, “Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression,” Obesity Research, vol. 11, no. 4, pp. 525–531, 2003.
View at: Google Scholar
A Ble, B G Windham, S Bandinelli et al., “Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti study),” The American Journal of Cardiology, vol. 96, no. 7, pp. 991–995, 2005.
View at: Google Scholar
Y Wang, K K Kuropatwinski, D W White et al., “Leptin receptor action in hepatic cells,” The Journal of Biological Chemistry, vol. 272, no. 26, pp. 16216–16223, 1997.
View at: Google Scholar
C Korkmaz, H Özdogan, Ö Kasapçopur, and H Yazici, “Acute phase response in familial Mediterranean fever,” Annals of the Rheumatic Diseases, vol. 61, no. 1, pp. 79–81, 2002.
View at: Google Scholar
R van Crevel, E Karyadi, M G Netea et al., “Decreased plasma leptin concentrations in tuberculosis patients are associated with wasting and inflammation,” The Journal of Clinical Endocrinology & Metabolism, vol. 87, no. 2, pp. 758–763, 2002.
View at: Google Scholar
R C Frederich, A Hamann, S Anderson, B Löllmann, B B Lowell, and J S Flier, “Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action,” Nature Medicine, vol. 1, no. 12, pp. 1311–1314, 1995.
View at: Google Scholar
K Nishiya, M Nishiyama, A Chang, A Shinto, and K Hashimoto, “Serum leptin levels in patients with rheumatoid arthritis are correlated with body mass index,” Rinsho Byori, vol. 50, no. 5, pp. 524–527, 2002 (Japanese).
View at: Google Scholar
H-J Anders, M Rihl, A Heufelder, O Loch, and M Schattenkirchner, “Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis,” Metabolism, vol. 48, no. 6, pp. 745–748, 1999.
View at: Google Scholar

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Copyright © 2006 Bülent Toy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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