Primary Cardiac Angiosarcoma

Kodali, Dhatri; Seetharaman, Kala

doi:https://doi.org/10.1155/SRCM/2006/39130

Sarcoma

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Case Report | Open Access

Volume 2006 | Article ID 039130 | https://doi.org/10.1155/SRCM/2006/39130

Primary Cardiac Angiosarcoma

Dhatri Kodali¹and Kala Seetharaman²

Received31 May 2005

Revised04 Jun 2006

Accepted08 Jun 2006

Published03 Oct 2006

Abstract

Primary cardiac sarcoma is a rare clinical entity, with an incidence of 0.0001% in collected autopsy series. The majority of the literature describes a uniformly dismal prognosis with a median survival of only 6 months for these aggressive tumors. Standard surgery, adjuvant chemotherapy, and radiotherapy have been consistently unsuccessful. Early heart transplantation and novel radiation therapy approaches may offer a survival benefit in nonmetastatic tumors, but up to 80% of the patients present with systemic metastasis at diagnosis. Though several chemotherapeutic regimens have been tried, the role of chemotherapy is not well established and outcome data available is minimal. Liposomal doxorubicin (PLD) has been shown to be useful in the treatment of soft tissue sarcomas, and our case supports its use in cardiac angiosarcoma.

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Copyright

Copyright © 2006 Dhatri Kodali and Kala Seetharaman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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