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Thromb Haemost 2014; 111(03): 483-490
DOI: 10.1160/TH13-08-0632
Platelets and Blood Cells
Schattauer GmbH

The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer

Zsolt Baranyai   *
1   Tumorgenetika Human Biospecimen Collection and Research Company, Budapest, Hungary
2   1st Department of Surgery, Semmelweis University, Budapest, Hungary
,
Marcin Krzystanek   *
3   Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
,
Valéria Jósa
1   Tumorgenetika Human Biospecimen Collection and Research Company, Budapest, Hungary
,
Kristóf Dede
4   Department of Surgery and Vascular Surgery, Uzsoki Memorial Hospital, Budapest, Hungary
,
Emese Ágoston
2   1st Department of Surgery, Semmelweis University, Budapest, Hungary
,
Marcell Szász
5   2nd Department of Pathology, Semmelweis University, Budapest, Hungary
,
Dániel Sinkó
6   Department of Oncology, Uzsoki Memorial Hospital, Budapest, Hungary
,
Viktor Szarvas
6   Department of Oncology, Uzsoki Memorial Hospital, Budapest, Hungary
,
Ferenc Salamon
7   Department of Pathology, Uzsoki Memorial Hospital, Budapest, Hungary
,
Aron Charles Eklund
3   Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
,
Zoltán Szállási
3   Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
8   Informatics Program, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
,
Ferenc Jakab
4   Department of Surgery and Vascular Surgery, Uzsoki Memorial Hospital, Budapest, Hungary
› Author Affiliations
Further Information

Publication History

Received: 02 August 2013

Accepted after major revision: 12 October 2013

Publication Date:
22 November 2017 (online)

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Summary

The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of different stages and with hepatic metastasis of CRC (mCRC) and to compare these factors as potential prognostic markers. Clinicopathological data of 10 years were collected retrospectively from 336 patients with CRC and 118 patients with mCRC. Both in the CRC and the mCRC group overall survival (OS) was significantly worse in patients who had elevated platelet count (hazard ratio [HR] = 2.2, p < 0.001 and HR = 2.9, p = 0.018, respectively). Multivariate analysis indicated that elevated platelet count was an independent prognostic factor of CRC (HR = 1.7, p = 0.035) and mCRC (HR = 3.1, p = 0.017). Disease-free survival (DFS) was significantly worse in patients with elevated platelet count in the CRC group (HR = 2.0, p = 0.011). In the multivariate analysis the PLR was not a prognostic factor in either of the two cohorts (HR = 0.92, p < 0.001 and HR = 0.89, p = 0.789, respectively). The platelet count is a valuable prognostic marker for the survival in patients both with CRC and mCRC while the PLR is not prognostic in either group.

Keywords

Platelet-lymphocyte ratio - thrombocytosis - colorectal cancer - survival

* Equal first authors of the manuscript.


 

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