| 宋颖秋,王天禄,党 军.PET/CT下合并肺不张非小细胞肺癌的治疗结果和预后分析[J].中国肿瘤,2017,26(1):68-72. |
| PET/CT下合并肺不张非小细胞肺癌的治疗结果和预后分析 |
| Prognosis of Non-small Cell Lung Cancer Complicated with Atelectasis Based on PET/CT |
| 投稿时间：2016-03-21 |
| DOI：10.11735/j.issn.1004-0242.2017.01.A011 |
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| 中文关键词: PET/CT 放疗 非小细胞肺癌 肺不张 预后 |
| 英文关键词:PET/CT radiation therapy non-small cell lung cancer atelectasis prognosis. |
| 基金项目:辽宁省科学技术计划项目（2013225021）； |
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| 中文摘要: |
| 摘 要：［目的］ 分析在PET/CT指导下合并肺不张的非小细胞肺癌（non-small cell lung cancer，NSCLC）的治疗结果及预后因素。［方法］ 对36例PET/CT定位扫描伴有不同程度肺不张的NSCLC患者的治疗结果进行分析，采用Kaplan-Meier法计算其生存率，Log-rank法检验和单因素预后分析，采用Cox模型多因素预后分析。［结果］ 1、2、3、5年生存率分别为61.1%、27.8%、13.9%和8.3%，中位生存期14个月；1、2、3、5年无进展生存率分别为36.1%、16.7%、8.3%和8.3%，中位无进展生存期10个月。单因素分析结果显示影响NSCLC合并肺不张预后因素有临床分期、是否复张、肺不张范围、治疗前血红蛋白含量。COX多因素分析显示，是否复张是合并肺不张NSCLC患者独立预后因素（χ2=7.88，P=0.043）。［结论］ PET/CT指导下治疗合并肺不张NSCLC有生存获益趋势，是否复张是影响其生存的独立预后因素，值得临床大样本前瞻性研究进一步探讨。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate prognostic factors in non-small cell lung cancer (NSCLC) patients complicated with atelectasis based on PET/CT. ［Methods］ The survival data of 36 NSCLC cases pathologically proven complicated with atelectasis with PET/CT scanning were analyzed prospectively. The factors related to survival was evaluated by univariate and multivariate analyses. ［Results］ The overall 1-，2-，3- and 5-year survival rate was 61.1%，27.8%，13.9% and 8.3% respectively，with a median survival time of 17 months. The 1-，2-，3- and 5-year progression free survival(PFS) rate was 36.1%，16.7%，8.3% and 8.3% respectively，with a median PFS of 10 months. Univariate analysis showed that clinical stage，re-expansion of atelectasis，the range of atelectasis，and hemoglobin were significant factors affecting survival . Multivariate analysis showed that resolution of atelectasis was the the only significant factor affecting survival(χ2=7.88，P=0.043).［Conclusion］ Re-expansion of the atelectasis is a predicting factor for a favorable outcome of NSCLC patients |
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