Background
Methods
Study Subjects and Procedures
Statistical analysis
Results
COPD Only | COPD and Asthma | p-value | |
---|---|---|---|
Total Subjects | 796 | 119 | -- |
Race: | |||
Non-Hispanic white | 672 (84.4) | 79 (66.4) | < 0.0001 |
African American | 124 (15.6) | 40 (33.6) | |
Gender | |||
Male | 423 (53.1) | 61 (51.3) | 0.77 |
Female | 373 (46.9) | 58 (48.7) | |
Age, years | 64.7 (8.2) | 61.3 (8.9) | 0.0001* |
Pack-years of smoking | 55.1 (27.3) | 43.7 (20.7) | < 0.0001* |
Current smoker | 270 (34.2) | 46 (38.7) | 0.35 |
BMI kg/m2 | 27.8 (6.0) | 28.1 (6.7) | 0.87* |
GOLD Stage | |||
2 | 408 (51.3) | 61 (51.3) | 0.99** |
3 | 251 (31.5) | 38 (31.9) | |
4 | 137 (17.2) | 20 (16.8) | |
BODE Index | 3.0 (2.1) | 3.2 (1.9) | 0.28* |
SGRQ | 38.6(20.5) | 44.0 (21.9) | 0.0075* |
6MWT (ft) | 1140.2 (431.9) | 1158.8 (430.1) | 0.78* |
Severe exacerbations | 140 (17.6) | 39 (32.8) | 0.0003 |
Frequent exacerbations | 114 (18.0) | 41 (42.7) | < 0.0001 |
Hay fever | 204 (27.8) | 65 (57.0) | < 0.0001 |
Inhaled corticosteroid use | 387 (49.4) | 80 (69.0) | 0.25*** |
FEV1 % predicted | 49.4 (18.4) | 49.2 (17.5) | 0.85* |
FVC % predicted | 76.6 (17.9) | 78.3 (17.3) | 0.23* |
FEV1/FVC | 0.48 (0.13) | 0.48 (0.12) | 0.62* |
Presence of bronchodilator response, ATS definition | 270 (36.0) | 46 (41.1) | 0.30 |
Post bronchodilator % change in FEV1 | 8.7 (12.1) | 10.2 (12.5) | 0.33* |
Percent Emphysema, -950HU | 15.8 (13.5) | 13.7 (12.3) | 0.18* |
Percent gas-trapping, -856HU | 42.1 (20.3) | 43.1 (20.5) | 0.69* |
Airway wall thickness Pi10 | 3.78 (0.12) | 3.80 (0.14) | 0.34* |
Outcome | Additional Covariates | β(SE)/OR(CI) | p-value |
---|---|---|---|
BODE Index | age, gender, pack-years and race | 0.29 (0.21) | 0.17 |
SGRQ | age, gender, pack-years and race | 5.2 (2.0) | 0.009 |
6MWT, ft | age, gender, pack-years and race | 31.6 (40.5) | 0.43 |
Bronchodilator Response | age, gender, pack-years, and race | 1.40[0.92, 2.13] | 0.12 |
Severe exacerbations | age, gender, pack-years and race | 1.93 [1.24, 3.02] | 0.004 |
Frequent exacerbations | age, gender, pack-years and race | 3.55 [2.19, 5.75] | < 0.0001 |
Number of exacerbations | age, gender, pack-years and race | 0.68 (0.12) | < 0.0001 |
Percent Emphysema, -950HU | BMI, age, gender, pack-years, race and CT scanner* | -0.45 (1.23) | 0.71 |
Percent gas-trapping, -856HU | BMI, age, gender, pack-years, race and CT scanner | 4.31 (1.88) | 0.02 |
Airway wall thickness Pi10 | BMI, age, gender, pack-years, race and CT scanner | 0.016 (0.013) | 0.21 |
Variable | OR [CI] | p-value |
---|---|---|
African-American race | 2.05 [1.31, 3.21] | 0.002 |
Female gender | 0.94 [0.63, 1.40] | 0.76 |
Older age (per decade) | 0.76 [0.60, 0.97] | 0.03 |
Pack years of smoking (per 10 pack years) | 0.86 [0.78, 0.95] | 0.002 |