Background
Methods
Study population
Data collection
Genotyping
Statistical analysis
Results
Baseline clinical characteristics according to genotypes
rs10757274 |
P
| rs2383206 |
P
| rs10757278 |
P
| rs1333049 |
P
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N = 498 | N= 495 | N= 496 | N = 507 | |||||||||||||
Variables | AA | AG | GG | AA | AG | GG | AA | AG | GG | CC | GC | GG | ||||
Frequency
| 112 | 260 | 126 | 84 | 237 | 174 | 115 | 253 | 128 | 139 | 253 | 115 | ||||
Age (years)
| 60.1±9.3 | 59.4±9.0 | 59.3±8.9 | 0.73 | 60.5±8.7 | 59.1±9.3 | 59.5±9.1 | 0.50 | 59.9±9.3 | 59.5±9.2 | 59.4±9.3 | 0.91 | 59.1±9.2 | 60.0±9.2 | 59.4±9.0 | 0.65 |
Men (%)
| 65.2 | 66.9 | 71.4 | 0.55 | 65.5 | 65.4 | 71.3 | 0.42 | 64.3 | 66.8 | 70.3 | 0.60 | 70.5 | 65.6 | 67.8 | 0.61 |
Smoking (%)
| 34.8 | 28.5 | 42.9 |
0.02
| 28.6 | 31.6 | 37.4 | 0.30 | 32.2 | 30.4 | 39.8 | 0.18 | 40.3 | 28.9 | 33.0 | 0.07 |
Hy (%)
| 67.9 | 55.4 | 59.5 | 0.08 | 73.8 | 50.2 | 62.1 |
<0.01
| 67.0 | 53.8 | 60.2 |
0.05
| 60.4 | 54.2 | 65.2 | 0.12 |
DM (%)
| 49.1 | 39.2 | 29.4 |
0.01
| 52.4 | 40.1 | 32.8 |
0.01
| 47.8 | 37.9 | 32.0 |
0.04
| 34.5 | 36.4 | 49.6 |
0.03
|
BMI (kg/m2)
| 27.1±4.0 | 27.2±4.2 | 27.3±4.0 | 0.94 | 27.4±3.9 | 27.0±4.1 | 27.4±4.2 | 0.49 | 27.3±4.0 | 26.9±4.1 | 27.6±4.2 | 0.26 | 27.5±4.2 | 27.0±4.1 | 27.2±4.2 | 0.48 |
MI (%)
| 42.9 | 42.3 | 54.0 | 0.08 | 41.7 | 42.6 | 51.7 | 0.13 | 47.8 | 41.1 | 53.1 | 0.07 | 54.0 | 40.7 | 48.7 |
0.03
|
TC (mg/dL)
| 219.8±48.5 | 225.5±51.5 | 222.7±47.0 | 0.58 | 220.9±50.5 | 223.1±51.7 | 225.8±45.6 | 0.73 | 220.0±50.8 | 226.0±51.8 | 223.7±44.0 | 0.56 | 223.0±43.9 | 225.7±51.6 | 219.3±49.9 | 0.52 |
LDLc (mg/dL)
| 144.6±45.5 | 149.9±47.6 | 144.6±37.0 | 0.44 | 144.8±46.8 | 148.3±47.7 | 148.3±37.3 | 0.81 | 145.7±47.6 | 149.9±46.7 | 145.6±35.8 | 0.58 | 145.7±36.4 | 149.6±47.0 | 145.2±45.6 | 0.60 |
HDLc (mg/dL)
| 36.4±10.8 | 37.1±9.8 | 38.0±10.1 | 0.47 | 35.6±8.7 | 37.3±10.4 | 38.2±11.0 | 0.18 | 36.3±10.7 | 37.0±9.4 | 38.711.7 | 0.20 | 38.7±11.5 | 37.3±10.0 | 36.0±8.9 | 0.14 |
TG (mg/dL)
| 197.7±112.5 | 194.3±123.8 | 196.0±110.2 | 0.96 | 204.9±116.6 | 188.3±115.2 | 195.3±121.5 | 0.53 | 194.9±112.7 | 193.4±115.9 | 195.1±125.9 | 0.99 | 195.1±124.2 | 191.4±116.0 | 198.2±112.2 | 0.87 |
PCI (%)
| 29.5 | 33.1 | 37.3 | 0.51 | 27.4 | 35.0 | 35.1 | 0.23 | 33.9 | 30.8 | 39.8 | 0.30 | 38.8 | 32.0 | 32.2 | 0.43 |
CABG (%)
| 32.1 | 34.2 | 34.9 | 36.9 | 29.5 | 37.4 | 29.6 | 34.8 | 33.6 | 35.3 | 33.6 | 33.0 | ||||
CT (%)
| 38.4 | 32.7 | 27.8 | 35.7 | 35.4 | 27.6 | 36.5 | 34.4 | 26.6 | 25.9 | 34.4 | 34.8 | ||||
2-Vessel (%)
| 44.6 | 49.2 | 31.7 |
0.05
| 45.2 | 48.5 | 36.8 | 0.06 | 47.8 | 47.4 | 32.8 |
0.02
| 36.0 | 46.2 | 52.2 |
0.03
|
3-Vessel (%)
| 55.4 | 50.8 | 68.3 | 54.8 | 51.5 | 63.2 | 52.2 | 52.6 | 67.2 | 64.0 | 53.8 | 47.8 |
Cardiovascular end-points
rs10757274 |
P
| rs2383206 |
P
| rs10757278 |
P
| rs1333049 |
P
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N = 498 | N = 495 | N = 496 | N = 507 | |||||||||||||
Events | AA | AG | GG | AA | AG | GG | AA | AG | GG | CC | GC | GG | ||||
Refractory angina
| 17.9% | 18.5% | 15.9% | 0.82 | 19.0% | 16.0% | 17.2% | 0.81 | 19.1% | 17.0% | 16.4% | 0.84 | 15.8% | 17.4% | 19.1% | 0.79 |
PCI
| 9.8% | 13.8% | 9.5% | 0.35 | 9.5% | 12.2% | 10.3% | 0.73 | 11.3% | 11.9% | 10.9% | 0.96 | 10.8% | 12.6% | 11.3% | 0.84 |
MI
| 8.9% | 7.7% | 7.9% | 0.92 | 10.7% | 8.0% | 6.3% | 0.47 | 9.6% | 7.9% | 6.3% | 0.63 | 6.5% | 7.5% | 9.6% | 0.65 |
Cardiac death
| 8.9% | 9.2% | 11.1% | 0.81 | 8.3% | 7.2% | 13.2% | 0.11 | 8.7% | 7.5% | 13.3% | 0.18 | 11.5% | 9.5% | 7.0% | 0.47 |
Total death
| 11.6% | 13.8% | 17.5% | 0.42 | 11.9% | 11.0% | 19.5% |
0.04
| 12.2% | 13.0% | 17.2% | 0.45 | 15.8% | 14.6% | 11.3% | 0.57 |
Total events
| 25.9% | 29.2% | 26.2% | 0.73 | 27.4% | 25.3% | 27.4% | 0.74 | 26.1% | 27.3% | 27.3% | 0.97 | 25.9% | 28.9% | 25.2% | 0.71 |
P
|
OR
| 95.0% CI | ||
---|---|---|---|---|
Age
|
0.00
| 1.06 | 1.03 | 1.09 |
Diabetes mellitus
| 0.08 | 1.51 | 0.94 | 2.42 |
Smoking
| 0.39 | 1.26 | 0.74 | 2.14 |
Coronary anatomy
| 0.33 | 1.28 | 0.77 | 2.13 |
Previous myocardial infarction
|
0.02
| 1.76 | 1.09 | 2.84 |
rs10757274
| 0.31 | 1.31 | 0.78 | 2.21 |
P
|
OR
| 95.0% CI | ||
Age
|
0.00
| 1.06 | 1.03 | 1.09 |
Diabetes mellitus
| 0.15 | 1.41 | 0.88 | 2.27 |
Smoking
| 0.68 | 1.12 | 0.65 | 1.92 |
Coronary anatomy
| 0.28 | 1.32 | 0.79 | 2.20 |
Previous myocardial infarction
|
0.02
| 1.82 | 1.12 | 2.95 |
rs2383206
|
0.02
| 1.75 | 1.08 | 2.82 |
P
|
OR
| 95.0% CI | ||
Age
|
0.00
| 1.06 | 1.03 | 1.09 |
Diabetes mellitus
| 0.19 | 1.38 | 0.85 | 2.22 |
Smoking
| 0.77 | 1.09 | 0.63 | 1.89 |
Coronary anatomy
| 0.17 | 1.43 | 0.86 | 2.40 |
Previous myocardial infarction
|
0.02
| 1.81 | 1.11 | 2.94 |
rs10757278
| 0.32 | 1.30 | 0.78 | 2.18 |
P
|
OR
| 95.0% CI | ||
Age
|
0.00
| 1.06 | 1.03 | 1.09 |
Diabetes mellitus
| 0.11 | 1.46 | 0.91 | 2.32 |
Smoking
| 0.29 | 1.33 | 0.78 | 2.24 |
Coronary anatomy
| 0.15 | 1.44 | 0.88 | 2.37 |
Previous myocardial infarction
|
0.03
| 1.71 | 1.06 | 2.73 |
rs1333049
| 0.32 | 1.36 | 0.74 | 2.49 |