Background
Methods
Study group
Data source
Statistical analysis
Survival and regression analysis
Follow-up data
Results
Baseline characteristics of the entire population
Group I | Group II | Group III | Group IV | P value | |
---|---|---|---|---|---|
N = 607 | N = 574 | N = 663 | N = 706 | ||
<13.1% | 13.1 ≥ and <13.6% | 13.6% ≥ and <14.1% | ≥14.1 | ||
Age (yrs) | 62.3 ± 9.5 | 63.3 ± 9.4 | 64.4 ± 9.3 | 65.6 ± 9.1 | <0.0001 |
Men (%) | 436 (71.8) | 408 (71.1) | 461 (69.5) | 494 (70.0) | 0.8 |
Heart failure | 67 (11.0) | 69 (12.0) | 77 (11.7) | 146 (20.7) | <0.0001 |
Atrial fibrillation | 39 (6.4%) | 50 (8.7%) | 75 (11.3%) | 123 (17.4) | <0.0001 |
Hypertension | 428 (70.5) | 431 (75.1) | 477 (71.9) | 491 (69.5) | 0.15 |
Previous MI | 343 (56.5%) | 320 (55.7%) | 373 (56.3%) | 437 (61.9%) | 0.07 |
Previous CABG | 69 (11.4) | 83 (14.5) | 89 (13.4) | 99 (14.0) | 0.38 |
Previous PCI | 307 (50.6) | 274 (47.7) | 306 (46.2) | 367 (52.0) | 0.08 |
Previous SCD | 10 (1.6%) | 20 (3.5) | 21 (3.2) | 26 (3.7) | 0.14 |
PVD | 24 (4.0) | 34 (5.9) | 37 (5.6) | 47 (6.7) | 0.19 |
Prev. Stroke/TIA | 19 (3.1) | 27 (4.7) | 39 (5.9) | 60 (8.5) | 0.0003 |
CKD GFR < 60 ml/h/1.73 m2
| 40 (6.6) | 59 (10.3) | 91 (13.7) | 137 (19.4) | <0.0001 |
Diabetes | 210 (34.6) | 215 (37.5) | 238 (35.9) | 280 (39.7) | 0.26 |
Insulin | 61 (10.0) | 86 (15.0) | 85 (12.8) | 127 (18.0) | 0.0004 |
Lipid abnormalities | 363 (59.8) | 357 (62.2) | 387 (58.4) | 353 (50.0) | <0.0001 |
Obesity | 203 (33.4) | 192 (33.4) | 234 (35.3) | 252 (35.7) | 0.75 |
COPD | 32 (5.3) | 35 (6.1) | 45 (6.8) | 79 (11.2) | 0.0001 |
Current smoker | 59 (9.7) | 65 (11.3) | 73 (11.0) | 85 (12.0) | 0.68 |
Previous smoker | 202 (33.3%) | 196 (34.1) | 226 (34.1) | 259 (36.7) | 0.67 |
FH of premature CHD | 65 (10.7) | 48 (8.4) | 70 (10.6) | 47 (6.7) | 0.11 |
NYHA class III/IV | 28 (4.6%) | 40 (7.0%) | 33 (5.0%) | 86 (12.2%) | <0.0001 |
Disabling angina (CCS III/IV) | 97 (16.0) | 92 (16.0) | 115 (17.3) | 115 (16.3) | 0.9 |
HR (1/min) | 69.3 ± 10.9 | 70.2 ± 11.4 | 71.9 ± 11.8 | 73.0 ± 12.9 | <0.0001 |
SBP (mmHg) | 133± 19.7 | 133.0 ± 19.7 | 132.3 ± 18.5 | 132 ± 20.6 | 0.65 |
DBP (mmHg) | 79.3 ± 10.8 | 78.9 ± 11.3 | 78.8 ± 10.6 | 78.4 ± 12.0 | 0.20 |
Sinus rhythm - | 588 (96.9) | 547 (95.3) | 620 (93.5) | 632 (89.5) | <0.0001 |
Ejection fraction (%) | 46.7 ± 9.7 | 47.8 ± 9.48 | 46.4 ± 10.0 | 43.8 ± 11.4 | <0.0001 |
BMS | 253 (41.7%) | 284 (49.5%) | 387 (58.4%) | 435 (61.6%) | <0.0001 |
MVD | 68 (11.2) | 92 (16.0) | 106 (16.0) | 113 (16.0) | 0.04 |
No. of PCI vessels | 1.2 ± 0.5 | 1.2 ± 0.5 | 1.2 ± 0.5 | 1.3 ± 05 | 0.82 |
No. of stents | 1.4 ± 0.7 | 1.4 ± 0.7 | 1.3 ± 0.6 | 1.4 ± 0.7 | 0.41 |
Group I | Group II | Group III | Group IV | P value | |
---|---|---|---|---|---|
N = 607 | N = 574 | N = 663 | N = 706 | ||
<13.1% | 13.1 ≥ and <13.6% | 13.6% ≥ and <14.1% | ≥14.1 % | ||
RBC (mln/mm3) | 4.5 ± 0.4 | 4.5 ± 0.5 | 4.5 ± 0.5 | 4.5 ± 0.5 | 0.02 |
HGB (mmol/l) | 8.7 ± 0.8 | 8.6 ± 0.9 | 8.6 ± 0.8 | 8.3 ± 1.0 | <0.0001 |
HCT (%) | 40.4 ± 3.4 | 40.6 ± 4.3 | 40.8 ± 3.8 | 39.8 ± 4.4 | <0.0001 |
MCV (mm3) | 90.6 ± 3.9 | 89.0 ± 3.8 | 90.5 ± 4.3 | 89.9 ± 5.6 | 0.01 |
RDW (%) | 12.6 ± 0.4 | 13.3 ± 0.1 | 13.8 ± 0.2 | 15.0 ± 1.2 | <0.0001 |
WBC (tys/mm3) | 7.1 ± 1.9 | 7.3 ± 2.0 | 7.4 ± 2.6 | 7.4 ± 2.2 | 0.17 |
PLT (tys/mm3) | 211.3 ± 51.3 | 210.0 ± 59.4 | 207.4 ± 60.6 | 213.3 ± 73.7 | 0.19 |
Creatinine (μmol/l) | 79.8 ± 32.6 | 80,3 ± 22.8 | 83,2 ± 24.7 | 89,8 ± 48.1 | <0.0001 |
GFR (ml/min/1.73 m2) | 90.0 ± 21.9 | 89.4 ± 25.5 | 85.5 ± 24.2 | 82,4 ± 26.5 | <0.0001 |
Sodium (mmol/l) | 138.5 ± 2.6 | 138.3 ± 2.8 | 138.7 ± 2.64 | 138.5 ± 2.8 | 0.09 |
Glucose (mmol/l) | 6.2 ± 2.0 | 6.1 ± 2.0 | 6.0 ± 1.6 | 5.9 ± 1.7 | 0.18 |
Cholesterol (mmol/l) | 4.3 ± 1.1 | 4.5 ± 1.2 | 4.4 ± 1.1 | 4.5 ± 1.3 | 0.08 |
Group I | Group II | Group III | Group IV | P value | |
---|---|---|---|---|---|
N = 607 | N = 574 | N = 663 | N = 706 | ||
<13.1% | 13.1 ≥ and <13.6% | 13.6% ≥ and <14.1% | ≥14.1% | ||
Aspirin | 601 (99.0) | 569 (99.1) | 658 (99.2) | 693 (98.2) | 0.21 |
Clopidogrel/Thienopiridines | 607 (100) | 572 (99.7) | 658 (99.2) | 699 (99.0) | 0.25 |
ACE-I/ARB | 585 (96.4) | 539 (93.9) | 622 (93.8) | 641 (90.8) | 0.0006 |
Beta-blockers | 581 (95.7) | 555 (96.7) | 630 (95.0) | 671 (95.0) | 0.44 |
Calcium channel blockers | 106 (17.5) | 82 (14.3) | 100 (15.1) | 112 (15.9) | 0.47 |
Diuretics | 203 (33.4) | 194 (33.8) | 229 (34.5) | 315 (44.6) | <0.0001 |
Nitrates | 121 (19.9) | 166 (28.9) | 223 (33.6) | 233 (33.0) | <0.0001 |
VKA | 23 (3.8) | 32 (5.6) | 47 (7.1) | 83 (11.8) | <0.0001 |
Survival analysis and predictors of outcome
Hazard ratio | 95% CI | P value | |
---|---|---|---|
Whole group | 1.23 | 1.13-1.35 | <0.0001 |
Females | 1.31 | 1.06-1.62 | 0.01 |
Males | 1.22 | 1.1-1.34 | 0.0001 |
≥75 years | 1.36 | 1.05-1.78 | 0.02 |
<75 years | 1.21 | 1.09-1.33 | 0.0003 |
Anemia | 1.17 | 1.02-1.34 | 0.02 |
Without anemia | 1.37 | 1.19-1.58 | <0.0001 |
With CKD | 1.49 | 1.32-1.82 | 0.0001 |
Without CKD | 1.16 | 1.04-1.29 | 0.009 |
Diabetes | 1.23 | 1.08-1.4 | 0.002 |
Without diabetes | 1.27 | 1.12-1.46 | 0.0003 |
Heart failure | 1.20 | 1.04-1.39 | 0.01 |
Without heart failure | 1.39 | 1.07-1.8 | 0.01 |