Background
Methods
Study population
Data collection
Physical examination
Echocardiography
Calculation of derived variables
Statistical analysis
Results
Clinical and echocardiographic characteristics of untreated hypertensive population
Variables | Whole group (n = 1641) | Male (n = 1044) | Female (n = 597) | p value |
---|---|---|---|---|
Age (years)
| 50.4 ± 12.18 | 47.8 ± 12.26 | 55.1 ± 10.53 | <0.001 |
Height (cm)
| 165.6 ± 8.76 | 170.3 ± 6.47 | 157.5 ± 5.90 | <0.001 |
Weight (kg)
| 73.5 ± 12.97 | 78.7 ± 11.76 | 65.6 ± 9.75 | <0.001 |
BMI (kg/m
2
)
| 26.7 ± 3.38 | 27.1 ± 3.28 | 26.0 ± 3.50 | <0.001 |
BSA (m
2
)
| 1.8 ± 0.19 | 1.9 ± 0.16 | 1.7 ± 0.13 | <0.001 |
SBP (mmHg)
| 139.5 ± 15.29 | 138.8 ± 14.69 | 140.7 ± 16.23 | 0.013 |
DBP (mmHg)
| 92.0 ± 9.34 | 93.7 ± 8.83 | 88.9 ± 9.43 | <0.001 |
PP(mmHg)
| 47.5 ± 15.52 | 45.1 ± 14.19 | 51.8 ± 16.79 | <0.001 |
MAP (mmHg)
| 107.8 ± 9.09 | 108.7 ± 8.90 | 106.2 ± 9.19 | <0.001 |
Plasma glucose (mmol/L)
| 5.5 ± 1.86 | 5.4 ± 1.98 | 5.7 ± 1.59 | <0.001 |
Cholesterol (mmol/L)
| 5.4 ± 1.05 | 5.5 ± 1.05 | 5.3 ± 1.03 | 0.017 |
Triglyceride (mmol/L)
| 2.0 ± 1.54 | 2.2 ± 1.78 | 1.7 ± 0.97 | <0.001 |
High density lipoprotein (mmol/L)
| 1.5 ± 0.36 | 1.4 ± 0.37 | 1.5 ± 0.35 | <0.001 |
Low density lipoprotein (mmol/L)
| 3.0 ± 1.02 | 3.0 ± 1.08 | 3.0 ± 0.91 | 0.727 |
Diabetes (%)
| 94(5.7) | 46(4.4) | 48(8.1) | 0.003 |
Obesity (%)
| 252(15.4) | 176(16.9) | 76(12.7) | 0.027 |
Variables | Whole group (n = 1641) | Male (n = 1044) | Female (n = 597) | p value |
---|---|---|---|---|
IVSd (mm)
| 10.6 ± 2.14 | 10.5 ± 2.20 | 10.7 ± 2.03 | 0.053 |
PWTd (mm)
| 9.4 ± 1.54 | 9.5 ± 1.46 | 9.1 ± 1.64 | <0.001 |
LVIDD (mm)
| 44.4 ± 5.25 | 45.3 ± 4.97 | 42.9 ± 5.37 | <0.001 |
LV mass(g)
| 152.5 ± 46.43 | 158.1 ± 48.04 | 142.5 ± 41.69 | <0.001 |
LVMI-BSA(g/m
2
)
| 84.5 ± 24.70 | 83.5 ± 25.13 | 86.2 ± 23.84 | 0.027 |
LVMI-height
2.7
(g/m
2.7
)
| 39.4 ± 12.60 | 37.8 ± 12.24 | 42.0 ± 12.79 | <0.001 |
RWT(cm)
| 0.43 ± 0.092 | 0.43 ± 0.085 | 0.44 ± 0.102 | 0.117 |
Prevalence of LVH in untreated hypertensive population
The distribution of LV geometric patterns
Subgroup | Normal geometry [n(%)] | Concentric remodeling [n(%)] | Concentric hypertrophy [n(%)] | Eccentric hypertrophy [n(%)] | Abnormal geometry [n(%)] |
---|---|---|---|---|---|
Sex
| |||||
Male
| 521(49.9) | 375(35.9) | 74(7.1) | 74(7.1) | 523(50.1) |
Female
| 216(36.2) | 197(33.0) | 108(18.1) | 76(12.7) | 381(63.8) |
Age group (years)
| |||||
<45
| 305(56.2) | 197(36.3) | 20(3.7) | 21(3.9) | 238(43.8) |
45-60
| 317(45.2) | 241(34.4) | 75(10.7) | 68(9.7) | 384(54.8) |
≥60
| 115(29.0) | 134(33.8) | 87(21.9) | 61(15.4) | 282(71.0) |
Total
| 737(44.9) | 572(34.9) | 182(11.1) | 150(9.1) | 904(55.1) |
The risk factors of LVH in untreated hypertensive patients
Variables | Odds ratio | 95% CI | P |
---|---|---|---|
Age,year
| 1.06 | 1.05-1.07 | <0.001 |
Sex (0 = male,1 = female)
| 1.94 | 1.38-2.74 | <0.001 |
SBP,mmHg
| 1.02 | 1.01-1.03 | <0.001 |
BMI, kg/m
2
| 1.19 | 1.14-1.24 | <0.001 |
Cholesterol, mmol/L
| 0.876 | 0.759-1.010 | 0.069 |
HDL, mmol/L
| 0.66 | 0.42-1.05 | 0.079 |
Drinking history (0 = no,1 = yes)
| 0.69 | 0.47-1.02 | 0.060 |
The risk factors of abnormal LV geometric patterns in untreated hypertensive patients
Variables | Concentric remodeling | Concentric hypertrophy | Eccentric hypertrophy | ||||||
---|---|---|---|---|---|---|---|---|---|
Odds ratio | 95% CI | P | Odds ratio | 95% CI | P | Odds ratio | 95% CI | P | |
Age,year
| 1.02 | 1.01-1.03 | <0.001 | 1.07 | 1.05-1.09 | <0.001 | 1.06 | 1.04-1.08 | <0.001 |
Sex
| |||||||||
(0 = male,1 = female)
| 1.20 | 0.93-1.55 | 0.158 | 2.51 | 1.70-3.71 | <0.001 | 1.76 | 1.07-2.87 | 0.025 |
SBP,mmHg
| 1.00 | 0.99-1.01 | 0.615 | 1.03 | 1.02-1.04 | <0.001 | 1.02 | 1.00-1.03 | 0.020 |
BMI, kg/m
2
| 0.99 | 0.95-1.03 | 0.567 | 1.17 | 1.11-1.24 | <0.001 | 1.21 | 1.14-1.29 | <0.001 |
HDL, mmol/L
| 0.92 | 0.64-1.31 | 0.651 | 0.95 | 0.54-1.69 | 0.865 | 0.37 | 0.18-0.73 | 0.004 |
Drinking history (0 = no,1 = yes)
| 1.00 | 0.75-1.33 | 0.974 | 0.76 | 0.44-1.31 | 0.321 | 0.53 | 0.31-0.94 | 0.028 |