Background
Methods
Study groups
Cohort (n = 223) | Characteristic |
aSer/Ser (n = 170) |
aSer/Leu (n = 43) |
aLeu/Leu (n = 10) |
---|---|---|---|---|
No (%) of patients | Co-existing diseases | |||
103 (46.2) | Arterial hypertension | 77 (74.8) | 22 (21.4) | 4 (3.9) |
82 (36.8) | Myocardial disease | 67 (81.7) | 14 (17.0) | 1 (1.2) |
53 (23.8) | Diabetes | 35 (66.0) | 14 (26.0) | 4 (7.5) |
52 (23.3) | Lung pathology | 44 (84.6) | 6 (11.5) | 2 (3.8) |
16 (7.2) | Renal pathology | 11 (68.8) | 4 (25.0) | 1 (6.3) |
No (%) of patients
|
Type of surgery
| |||
76 (34.1) | Upper-GI resection | 58 (76.3) | 16 (21.1) | 2 (2.6) |
62 (27.8) | Colorectal resection | 46 (74.2) | 12 (19.4) | 4 (6.5) |
50 (22.4) |
bOther abdominal | 37 (74.0) | 10 (20.0) | 3 (6.0) |
15 (6.7) | Thoracic | 11 (73.4) | 3 (20.0) | 1 (6.7) |
20 (9.0) | Limb and others | 18 (90.0) | 2 (10.0) | - - |
No (%) of infections
|
Type of Infection
| |||
92 (41.3) | Pneumonia | 68 (73.9) | 20 (21.7) | 4 (4.3) |
38 (17.0) | Peritonitis | 27 (71.1) | 9 (23.7) | 2 (5.3) |
65 (29.2) | Abscess | 52 (80.0) | 10 (15.4) | 3 (4.6) |
4 (1.8) | Urinary tract infections | 3 (75.0) | 1 (25.0) | - - |
24 (10.8) | Other | 20 (83.3) | 3 (12.5) | 1 (4.2) |
No (%) of infections
c
|
Microorganisms
| |||
129 (57.9) | Gram-negative | 97 (75.2) | 25 (19.4) | 7 (5.4) |
83 (37.2) | Gram-positive | 60 (72.3) | 18 (21.7) | 5 (6.0) |
15 (6.7) | Fungi | 13 (86.7) | 2 (13.3) | - - |
31 (13.9) | Polymicrobial | 19 (61.3) | 9 (29.0) | 3 (9.8) |
24 (10.8) | Clinically diagnosed | 15 (62.5) | 8 (33.3) | 1 (4.2) |
No (%) of patients
|
Morbidity and Mortality
| |||
114 (51.1) | Sepsis without organ dysfunction | 90 (78.9) | 22 (19.3) | 2 (1.8) |
109 (48.9) | Severe sepsis and septic shock | 80 (73.4) | 21 (19.3) | 8 (7.3)d
|
28 (12.6) | Mortality ICU | 21 (75.0) | 6 (21.4) | 1 (3.6) |
34 (15.3) | Mortality hospital | 26 (76.5) | 7 (20.6) | 1 (2.9) |
Ethical approval
Sample size calculations
Genotyping
Statistical analysis
Results
No. of individuals with genotype (%) | ||||||
---|---|---|---|---|---|---|
Population and disease | No. | Variant Allele Frequency (%) | Ser/Ser | Ser/Leu | Leu/Leu |
P valuea
|
Ghana, delivering women | ||||||
P. falciparum positive | 541 | 0.1 | 540 (99.8) | 1 (0.2) | 0 (0) | 0.49 |
P. falciparum negative | 554 | 0 | 554 (100) | 0 (0) | 0 (0) | |
Germany | ||||||
Sepsis patients | 223 | 18.1 | 170 (76.2) | 43 (19.3) | 10 (4.5) | 0.19 |
Controls | 188 | 19.2 | 138 (74.4) | 48 (25.5) | 2 (1.1)b
| |
Bangladesh | ||||||
Leprosy patients | 263 | 16.3 | 186 (70.7) | 68 (25.9) | 9 (3.4) | 0.22 |
Controls | 280 | 17.2 | 188 (67.1) | 88 (31.5) | 4 (1.4) | |
Turkey | 0.11 | |||||
Leprosy patients | 60 | 10.8 | 47 (78) | 13 (21) | 0 (0) | |
Controls | 100 | 6.5 | 88 (88) | 11 (11) | 1 (1) |