Background
Methods
Study patients
Selection and genotyping of single-nucleotide polymorphisms
Statistical analyses
Results
Classifications and clinical characteristics of the study patients
Clinical profile | Polyp-positive | Polyp-negative |
P-value |
---|---|---|---|
Number of subjects (n) | 158 | 309 | |
Age [year, mean (range)] | 46.24 (17.93-76.86) | 47.00 (15.40 - 77.88) | 0.56 |
Sex (n, male/female) | 55/103 | 100/209 | 0.60 |
Total smoker (Current Smoker; Ex-Smoker) (%) | 27.21 (11.39; 15.82) | 27.83 (11.33; 16.50) | 0.93 |
Body mass index (kg/m2) | 23.95 ± 3.00 | 24.53 ± 3.51 | 0.06 |
% fall of FEV1 by aspirin provocation | 12.22 ± 14.39 | 6.78 ± 11.46 |
< 0.0001
|
Blood eosinophil (%) | 6.92 ± 6.23 | 5.98 ± 6.00 | 0.12 |
PC20 methacholine (mg/ml) | 5.83 ± 8.87 | 6.88 ± 8.62 | 0.23 |
Total IgE (IU/ml) | 298.35 ± 469.67 | 368.39 ± 654.01 | 0.19 |
FEV1 (% predicted) | 89.67 ± 15.76 | 91.79 ± 17.33 | 0.18 |
FVC (% predicted) | 89.02 ± 12.65 | 87.68 ± 14.56 | 0.30 |
Positive rate of skin test (%) | 51.90 | 57.61 | 0.24 |
Positive rate of aspirin intolerance (%) | 41.77 | 15.53 |
< 0.0001
|
Distribution of EMID2variants
Association analysis of EMID2variants with nasal polyps in asthma patients
SNP/Haplotype | MAF | Co-dominant | Dominant | Recessive | Statistical Power | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Polyp-positive (n = 158) | Polyp-negative (n = 309) | OR(95%CI) |
P*
|
P
corr
**
| OR(95%CI) |
P*
|
P
corr
**
| OR(95%CI) |
P*
|
P
corr
**
| ||
rs6945102C > T
| 0.228 | 0.322 | 0.62(0.45-0.87) |
0.005
| NS | 0.60(0.40-0.91) |
0.02
| NS | 0.39(0.16-0.92) |
0.03
| NS | 62.03 |
rs4729697A > G
| 0.224 | 0.321 | 0.61(0.44-0.86) |
0.004
| NS | 0.59(0.39-0.89) |
0.01
| NS | 0.39(0.16-0.93) |
0.03
| NS | 60.92 |
rs221G > A
| 0.252 | 0.337 | 0.67(0.49-0.93) |
0.02
| NS | 0.64(0.43-0.97) |
0.04
| NS | 0.48(0.22-1.06) | 0.07 | - | 66.93 |
rs10435333G > A
| 0.252 | 0.337 | 0.67(0.48-0.93) |
0.02
| NS | 0.64(0.43-0.97) |
0.03
| NS | 0.49(0.22-1.07) | 0.07 | - | 66.93 |
rs6947185C > A
| 0.433 | 0.537 | 0.69(0.52-0.92) |
0.01
| NS | 0.69(0.44-1.09) | 0.11 | - | 0.53(0.32-0.87) |
0.01
| NS | 72.99 |
rs4727494G > A
| 0.263 | 0.359 | 0.65(0.47-0.90) |
0.009
| NS | 0.65(0.43-0.98) |
0.04
| NS | 0.40(0.18-0.87) |
0.02
| NS | 66.22 |
rs13233066G > A
| 0.275 | 0.362 | 0.70(0.51-0.95) |
0.02
| NS | 0.65(0.43-0.97) |
0.04
| NS | 0.60(0.30-1.19) | 0.14 | - | 69.05 |
rs1008064T > C
| 0.494 | 0.430 | 1.32(1.00-1.75) |
0.05
| NS | 1.46(0.94-2.26) | 0.10 | - | 1.48(0.92-2.38) | 0.10 | - | 77.44 |
rs1543883T > C
| 0.506 | 0.450 | 1.32(1.00-1.76) |
0.05
| NS | 1.51(0.96-2.38) | 0.08 | - | 1.41(0.88-2.25) | 0.16 | - | 78.55 |
rs13245946C > T
| 0.108 | 0.073 | 1.53(0.95-2.45) | 0.08 | - | 1.36(0.79-2.33) | 0.26 | - | 13.01(1.45-116.41) |
0.02
| NS | 41.62 |
EMID2_BL1_ht2
| 0.180 | 0.290 | 0.54(0.37-0.77) |
0.0008
|
0.03
| 0.53(0.35-0.82) |
0.004
| NS | 0.22(0.06-0.74) |
0.01
| NS | 71.84 |
EMID2_BL2_ht2
| 0.259 | 0.356 | 0.64(0.47-0.89) |
0.007
| NS | 0.63(0.42-0.95) |
0.03
| NS | 0.42(0.19-0.92) |
0.03
| NS | 81.64 |
EMID2_BL3_ht1
| 0.453 | 0.510 | 0.74(0.56-0.98) |
0.03
| NS | 0.66(0.42-1.02) | 0.06 | - | 0.67(0.42-1.08) | 0.10 | - | 88.51 |
SNP/Haplotype | MAF | Co-dominant | Dominant | Recessive | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Polyp-positive (n = 66) | Polyp-negative (n = 48) | OR(95%CI) |
P*
|
P
corr
**
| OR(95%CI) |
P*
|
P
corr
**
| OR(95%CI) |
P*
|
P
corr
**
| |
rs6945102C > T
| 0.205 | 0.365 | 0.43(0.22-0.84) |
0.01
| NS | 0.39(0.17-0.86) |
0.02
| NS | 0.27(0.05-1.51) | 0.14 | - |
rs4729697A > G
| 0.200 | 0.365 | 0.42(0.22-0.83) |
0.01
| NS | 0.38(0.17-0.84) |
0.02
| NS | 0.27(0.05-1.57) | 0.15 | - |
rs10237610C > T
| 0.554 | 0.438 | 1.82(1.01-3.29) |
0.05
| NS | 1.50(0.60-3.73) | 0.38 | - | 3.42(1.22-9.60) |
0.02
| NS |
rs221G > A
| 0.208 | 0.396 | 0.35(0.18-0.70) |
0.003
| NS | 0.35(0.16-0.78) |
0.01
| NS | 0.10(0.01-0.87) |
0.04
| NS |
rs10435333G > A
| 0.212 | 0.396 | 0.36(0.18-0.71) |
0.003
| NS | 0.36(0.16-0.81) |
0.01
| NS | 0.09(0.01-0.85) |
0.04
| NS |
rs9640666G > A
| 0.326 | 0.479 | 0.46(0.25-0.86) |
0.02
| NS | 0.35(0.15-0.84) |
0.02
| NS | 0.43(0.14-1.35) | 0.15 | - |
rs6947185C > A
| 0.400 | 0.531 | 0.52(0.28-0.94) |
0.03
| NS | 0.27(0.10-0.74) |
0.01
| NS | 0.65(0.25-1.69) | 0.37 | - |
rs4729705C > T
| 0.371 | 0.521 | 0.50(0.28-0.88) |
0.02
| NS | 0.25(0.10-0.63) |
0.003
| NS | 0.66(0.25-1.70) | 0.38 | - |
rs10254310G > A
| 0.432 | 0.552 | 0.58(0.34-1.01) | 0.06 | - | 0.39(0.15-0.98) |
0.04
| NS | 0.60(0.25-1.46) | 0.26 | - |
rs6949799T > C
| 0.546 | 0.417 | 1.77(1.02-3.08) |
0.04
| NS | 1.83(0.77-4.34) | 0.17 | - | 2.61(1.00-6.80) |
0.05
| NS |
rs4727491G > A
| 0.538 | 0.417 | 1.74(1.00-3.05) |
0.05
| NS | 1.83(0.77-4.34) | 0.17 | - | 2.48(0.95-6.51) | 0.06 | - |
rs13238748G > C
| 0.371 | 0.521 | 0.50(0.28-0.88) |
0.02
| NS | 0.25(0.10-0.63) |
0.003
| NS | 0.66(0.25-1.70) | 0.38 | - |
rs4727494G > A
| 0.220 | 0.385 | 0.46(0.25-0.86) |
0.01
| NS | 0.37(0.16-0.84) |
0.02
| NS | 0.36(0.10-1.37) | 0.14 | - |
rs13233066G > A
| 0.227 | 0.385 | 0.49(0.27-0.90) |
0.02
| NS | 0.37(0.16-0.84) |
0.02
| NS | 0.45(0.13-1.58) | 0.21 | - |
EMID2_BL1_ht1
| 0.538 | 0.417 | 1.83(1.02-3.26) |
0.04
| NS | 1.38(0.58-3.31) | 0.47 | - | 4.23(1.42-12.57) |
0.01
| NS |
EMID2_BL1_ht2
| 0.159 | 0.323 | 0.37(0.18-0.77) |
0.008
| NS | 0.34(0.15-0.77) |
0.01
| NS | 0.22(0.02-2.18) | 0.19 | - |
EMID2_BL2_ht2
| 0.220 | 0.385 | 0.46(0.25-0.86) |
0.01
| NS | 0.37(0.16-0.84) |
0.02
| NS | 0.36(0.10-1.37) | 0.14 | - |
SNP/Haplotype | MAF | Co-dominant | Dominant | Recessive | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Polyp-positive (n = 92) | Polyp-negative (n = 261) | OR(95%CI) |
P*
|
P
corr
**
| OR(95%CI) |
P*
|
P
corr
**
| OR(95%CI) |
P*
|
P
corr
**
| |
rs6947185C > A
| 0.457 | 0.538 | 0.72(0.51-1.01) | 0.06 | - | 0.86(0.50-1.50) | 0.60 | - | 0.46(0.25-0.84) |
0.01
| NS |
rs12538381C > T
| 0.109 | 0.094 | 1.18(0.69-2.05) | 0.55 | - | 1.01(0.55-1.86) | 0.99 | - | 10.96(1.08-111.20) |
0.04
| NS |
rs17135512A > G
| 0.109 | 0.094 | 1.18(0.69-2.05) | 0.55 | - | 1.01(0.55-1.86) | 0.99 | - | 10.96(1.08-111.20) |
0.04
| NS |
rs13245946C > T
| 0.125 | 0.069 | 1.85(1.08-3.16) |
0.02
| NS | 1.69(0.91-3.14) | 0.10 | - | 13.43(1.44-125.46) |
0.02
| NS |
EMID2_BL1_ht2
| 0.196 | 0.284 | 0.61(0.41-0.93) |
0.02
| NS | 0.65(0.39-1.06) | 0.08 | - | 0.20(0.05-0.88) |
0.03
| NS |
EMID2_BL4_ht1
| 0.266 | 0.201 | 1.42(0.96-2.09) | 0.08 | - | 2.68(1.05-6.85) |
0.04
| NS | 1.34(0.83-2.18) | 0.24 | - |