Background
Methods
Identification and eligibility of relevant study
Data extraction
Qualitative assessment
Statistical analysis
Result
Characteristics of eligible studies
Author/Year | Country | Ethnicity | Sepsis severity | Sources of control | Genotyping method | Quality score | Case/control | Case | Control | PHWE
| ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | AB | BB | AA | AB | BB | |||||||||
IL1α-889C/T
| ||||||||||||||
Davis 2010 | America | Hispanic | Sepsis | Community | TaqMan | 7 | 28/52 | 9 | 16 | 3 | 24 | 24 | 4 | 0.55 |
Gu 2010 | China | Asian | Sepsis | Hospital (trauma) | Probes | 8 | 165/141 | 114 | 42 | 9 | 107 | 31 | 3 | 0.67 |
IL-1B-511G/A
| ||||||||||||||
Johnson-1 2012 | America | Caucasian | Sepsis | Hospital (noninfected) | Mass-array | 9 | 245/263 | 103 | 114 | 28 | 101 | 120 | 42 | 0.53 |
Johnson-2 2012 | America | African-American | Sepsis | Hospital (noninfected) | Mass-array | 9 | 93/88 | 28 | 36 | 29 | 26 | 43 | 19 | 0.88 |
Wan 2012 | China | Asian | Sepsis | Hospital (transplanted) | PCR-RFLP | 7 | 21/60 | 11 | 6 | 4 | 12 | 30 | 18 | 0.94 |
Shimada 2011 | Japan | Asian | Sepsis | Hospital (critical ill) | Probes | 7 | 123/101 | 33 | 60 | 30 | 35 | 46 | 20 | 0.49 |
Davis 2010 | America | Hispanic | Sepsis | Community | TaqMan | 7 | 28/53 | 17 | 6 | 5 | 19 | 29 | 5 | 0.20 |
Gu 2010 | China | Asian | Sepsis | Hospital (trauma) | Probes | 8 | 167/140 | 57 | 83 | 27 | 34 | 61 | 45 | 0.15 |
Watanabe 2005 | Japan | Asian | Sepsis | Hospital (SIRS) | Probes | 6 | 68/45 | 19 | 49a
| 20 | 25a
| 0.86 | ||
IL-1B-31C/T
| ||||||||||||||
Shimada 2011 | Japan | Asian | Sepsis | Hospital (critical ill) | Probes | 8 | 122/101 | 36 | 58 | 28 | 34 | 47 | 20 | 0.61 |
Emonts 2010 | Netherlands | Caucasian | Sepsis | Community | SNaPshot | 7 | 84/456 | 10 | 37 | 37 | 57 | 214 | 185 | 0.69 |
Gu 2010 | China | Asian | Sepsis | Hospital (trauma) | Probes | 8 | 163/144 | 29 | 106 | 28 | 66 | 60 | 18 | 0.45 |
Barber 2004 | America | Caucasian | SS | Hospital (burn) | Pyro | 8 | 36/123 | 11 | 13 | 12 | 21 | 54 | 48 | 0.39 |
IL-1B + 3594C/T
| ||||||||||||||
Johnson-1 2012 | America | Caucasian | Sepsis | Hospital (noninfected) | Mass-array | 9 | 245/263 | 148 | 89 | 8 | 158 | 88 | 17 | 0.32 |
Johnson-2 2012 | America | African-American | Sepsis | Hospital (noninfected) | Mass-array | 9 | 93/88 | 61 | 29 | 3 | 65 | 20 | 3 | 0.36 |
Zhang 2005 | China | Asian | SSH | Hospital (ASP) | PCR-RFLP | 6 | 33/76 | 27 | 6 | 0 | 68 | 8 | 0 | 0.63 |
Balding 2003 | Ireland | Caucasian | Sepsis | Community | PCR-RFLP | 6 | 183/389 | 113 | 65 | 5 | 240 | 125 | 24 | 0.16 |
Treszl 2003 | Hungary | Caucasian | Sepsis | Hospital (VLBW) | PCR-RFLP | 6 | 33/70 | 20 | 11 | 2 | 41 | 25 | 4 | 0.94 |
Fang 1999 | Germany | Caucasian | SS | Community | PCR | 7 | 93/112 | 55 | 31 | 7 | 68 | 33 | 11 | 0.03 |
IL-1RN VNTR L/2
| ||||||||||||||
Zapata-Tarres 2013 | Mexico | Hispanic | SSH | Hospital (ALL) | PCR | 8 | 22/35 | 6 | 11 | 5 | 23 | 11 | 1 | 0.82 |
Wan 2012 | China | Asian | Sepsis | Hospital (transplanted) | PCR-RFLP | 7 | 21/60 | 17 | 4 | 0 | 51 | 9 | 0 | 0.53 |
Davis 2010 | America | Hispanic | Sepsis | Community | TaqMan | 7 | 28/50 | 12 | 14 | 2 | 27 | 20 | 3 | 0.78 |
Garcia-Segarra 2007 | Spain | Caucasian | SS and SSH | Community | PCR | 7 | 114/80 | 59 | 52 | 3 | 30 | 41 | 9 | 0.37 |
Watanabe 2005 | Japan | Asian | Sepsis | Hospital (SIRS) | PCR | 6 | 68/45 | 59 | 9a
| 39 | 6a
| 0.54 | ||
Bessler 2004 | Israel | Jews/Arabs | Sepsis | Community | PCR | 7 | 34/61 | 18 | 10 | 6 | 33 | 16 | 12 | 0.002 |
Balding 2003 | Ireland | Caucasian | Sepsis | Community | PCR-RFLP | 6 | 183/389 | 88 | 70 | 25 | 198 | 160 | 31 | 0.87 |
Arnalich 2002 | Spain | Caucasian | SS | Hospital (CAP) | PCR | 8 | 78/186 | 32 | 33 | 13 | 88 | 81 | 17 | 0.79 |
Ma 2002 | China | Asian | Sepsis | Community | PCR | 7 | 60/60 | 26 | 27 | 7 | 36 | 21 | 3 | 0.98 |
Fang 1999 | Germany | Caucasian | SS | Community | PCR | 7 | 93/261 | 37 | 43 | 13 | 152 | 92 | 17 | 0.54 |
Quantitative data synthesis
IL-1A-889(rs1800587) polymorphism
Dominant model | Recessive model | Allelic model | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | OR (95% CI) | P-value | Phet
| I2
| n | OR (95% CI) | P-value | Phet
| I2
| n | OR (95% CI) | P-value | Phet
| I2
| |
IL1A-889C/T
| |||||||||||||||
Total (sepsis)
| 2 | 1.49 (0.95-2.33) | 0.08 | 0.65 | 0% | 2 | 2.06 (0.75-5.67) | 0.16 | 0.56 | 0% |
2
|
1.47 (1.01-2.13)
|
0.04
|
0.98
|
0%
|
Ethnicity
| |||||||||||||||
Asian | 1 | 1.41 (0.85-2.34) | 0.19 | 1 | 2.65 (0.70-10.0) | 0.15 | 1 | 1.47 (0.94-2.30) | 0.09 | ||||||
Others | 1 | 1.81 (0.69-4.74) | 0.23 | 1 | 1.44 (0.30-6.94) | 0.65 | 1 | 1.46 (0.74-2.87) | 0.28 | ||||||
IL1B-511G/A
| |||||||||||||||
Total (sepsis)
| 7 | 0.81 (0.53-1.24) | 0.33 | <0.01 | 68% | 6 | 0.89 (0.53-1.50) | 0.66 | <0.01 | 67% | 6 | 0.82 (0.60-1.11) | 0.20 | <0.01 | 69% |
Ethnicity
| |||||||||||||||
Asian | 4 | 0.85 (0.39-1.87) | 0.69 | <0.01 | 81% | 3 | 0.67 (0.29-1.55) | 0.35 | 0.02 | 73% | 3 | 0.74 (0.38-1.34) | 0.29 | <0.01 | 84% |
Caucasian | 1 | 0.86 (0.60-1.23) | 0.40 | 1 | 0.68 (0.41-1.13) | 0.14 | 1 | 0.84 (0.65-1.08) | 0.18 | ||||||
Others | 2 | 0.63 (0.24-1.66) | 0.35 | 0.09 | 66% | 2 | 1.73 (0.95-3.14) | 0.07 | 0.76 | 0% | 2 | 0.98 (0.58-1.65) | 0.93 | 0.18 | 44% |
Quality score
| |||||||||||||||
≥7 | 6 | 0.72 (0.48-1.9) | 0.12 | 0.02 | 64% | 6 | 0.89 (0.53-1.50) | 0.66 | <0.01 | 67% | 6 | 0.82 (0.60-1.11) | 0.20 | <0.01 | 69% |
<7 | 1 | 2.06 (0.94-4.55) | 0.07 | ||||||||||||
IL1B-31C/T
| |||||||||||||||
Total (high quality)
| 4 | 1.29 (0.54-3.06) | 0.57 | <0.01 | 86% | 4 | 1.16 (0.86-1.56) | 0.34 | 0.69 | 0% | 4 | 1.18 (0.78-1.77) | 0.43 | <0.01 | 78% |
Ethnicity
| |||||||||||||||
Asian | 2 | 2.19 (0.70-6.90) | 0.18 | <0.01 | 89% | 2 | 1.33 (0.84-2.09) | 0.22 | 0.69 | 0% | 2 | 1.53 (0.91-2.57) | 0.11 | 0.04 | 77% |
Caucasian | 2 | 0.73 (0.33-1.61) | 0.43 | 0.15 | 52% | 2 | 1.04 (0.70-1.56) | 0.85 | 0.40 | 0% | 2 | 0.90 (0.57-1.43) | 0.65 | 0.14 | 55% |
Sepsis severity
| |||||||||||||||
Sepsis | 3 | 1.75 (0.74-4.11) | 0.20 | <0.01 | 84% | 3 | 1.24 (0.89-1.72) | 0.20 | 0.85 | 0% | 3 | 1.37 (0.93-2.00) | 0.11 | 0.03 | 72% |
Severe sepsis | 1 | 0.47 (0.20-1.10) | 0.08 | 1 | 0.78 (0.36-1.71) | 0.54 | 1 | 0.68 (0.40-1.15) | 0.15 | ||||||
Septic shock | |||||||||||||||
IL1B + 3594C/T
| |||||||||||||||
Total
| 6 | 1.06 (0.86-1.31) | 0.57 | 0.79 | 0% |
5
|
0.59 (0.36-0.97)
|
0.04
|
0.81
|
0%
| 6 | 0.97 (0.81-1.15) | 0.72 | 0.71 | 0% |
Ethnicity
| |||||||||||||||
Asian | 1 | 1.89 (0.60-5.96) | 0.28 | 1 | 1.80 (0.60-5.41) | 0.30 | |||||||||
Caucasian | 4 | 1.00 (0.80-1.25) | 0.99 | 0.74 | 0% |
4
|
0.57 (0.34-0.95)
|
0.03
|
0.74
|
0%
| 4 | 0.92 (0.76-1.11) | 0.37 | 0.99 | 0% |
Others | 1 | 1.48 (0.78-2.81) | 0.23 | 1 | 0.94 (0.19-4.81) | 0.95 | 1 | 1.34 (0.77-2.33) | 0.31 | ||||||
Sepsis severity
| |||||||||||||||
Sepsis | 4 | 1.04 (0.83-1.30) | 0.75 | 0.71 | 0% |
4
|
0.55 (0.31-0.97)
|
0.04
|
0.73
|
0%
| 4 | 0.95 (0.78-1.15) | 0.59 | 0.64 | 0% |
Severe sepsis | 1 | 1.07 (0.61-1.87) | 0.82 | 1 | 0.75 (0.28-2.01) | 0.56 | 1 | 0.98 (0.62-1.54) | 0.93 | ||||||
Septic shock | 1 | 1.89 (0.60-5.96) | 0.28 | 1 | 1.80 (0.60-5.41) | 0.30 | |||||||||
Quality score
| |||||||||||||||
≥7 | 3 | 1.08 (0.82-1.42) | 0.57 | 0.55 | 0% | 3 | 0.63 (0.34-1.14) | 0.13 | 0.71 | 0% | 3 | 0.98 (0.78-1.23) | 0.89 | 0.47 | 0% |
<7 | 3 | 1.04 (0.75-1.43) | 0.83 | 0.56 | 0% | 3 | 0.53 (0.23-1.25) | 0.15 | 0.37 | 0% | 3 | 0.95 (0.72-1.24) | 0.70 | 0.49 | 0% |
IL1RN VNTR L/2
| |||||||||||||||
Total
| 9 | 1.39 (0.97-1.98) | 0.07 | 0.01 | 59% | 8 | 1.67 (0.93-3.02) | 0.09 | 0.04 | 54% |
8
|
1.40 (1.01-1.95)
|
0.04
|
<0.01
|
72%
|
Ethnicity
| |||||||||||||||
Asian | 3 | 1.55 (0.89-2.68) | 0.12 | 0.58 | 0% | 1 | 2.51 (0.62-10.21) | 0.20 | 2 | 1.69 (1.01-2.84) | 0.05 | 0.64 | 0% | ||
Caucasian | 4 | 1.16 (0.72-1.88) | 0.54 | <0.01 | 75% | 4 | 1.39 (0.66-2.92) | 0.38 | 0.02 | 71% | 4 | 1.17 (0.77-1.78) | 0.45 | <0.01 | 82% |
Others | 2 | 2.68 (0.84-8.50) | 0.09 | 0.12 | 58% | 2 | 3.17 (0.40-25.32) | 0.28 | 0.15 | 52% | 2 | 2.27 (0.78-6.58) | 0.13 | 0.05 | 73% |
Sepsis severity
| |||||||||||||||
Sepsis | 5 | 1.26 (0.95-1.67) | 0.11 | 0.69 | 0% |
4
|
1.85 (1.12-3.04)
|
0.02
|
0.82
|
0%
|
4
|
1.31 (1.05-1.64)
|
0.02
|
0.70
|
0%
|
Severe sepsis |
2
|
1.67 (1.03-2.71)
|
0.04
|
0.18
|
44%
|
2
|
2.16 (1.25-3.72)
|
0.01
|
0.77
|
0%
|
2
|
1.60 (1.18-2.17)
|
<0.01
|
0.25
|
24%
|
Septic shock |
1
|
5.11 (1.59-16.46)
|
0.01
|
1
|
10.00 (1.08-92.49)
|
0.04
|
1
|
4.00 (1.72-9.31)
|
<0.01
| ||||||
Quality score
| |||||||||||||||
≥7 | 7 | 1.53 (0.95-2.47) | 0.08 | <0.01 | 67% | 7 | 1.62 (0.72-3.65) | 0.24 | 0.02 | 61% | 7 | 1.46 (0.96-2.21) | 0.08 | <0.01 | 75% |
<7 | 2 | 1.11 (0.79-1.55) | 0.55 | 0.84 | 0% | 1 | 1.83 (1.04-3.20) | 0.03 | 1 | 1.22 (0.93-1.60) | 0.14 |