Background
Methods
Primary search strategy
Criteria for study inclusion and exclusion
Data extraction
Statistical analysis
Results
Characteristics of studies
First author | Tumor site | 309TT | 309TG | 309GG | |||
---|---|---|---|---|---|---|---|
(reference ) | Case* | Control* | Case* | Control* | Case* | Control* | |
Yang M | GCA | 19/61/27 | 96/150/52 | 59/119/72 | 162/222/114 | 45/65/33 | 58/114/32 |
Singh V | BC | 10/11/4 | 4/18/3 | 23/21/4 | 13/32/2 | 13/13/5 | 11/15/7 |
Yoon YJ | HCC | 23/18/4 | 40/38/6 | 48/58/19 | 56/53/23 | 39/35/43 | 28/45/8 |
Xiong XJ | AML | 6/22/4 | 12/17/6 | 29/62/32 | 22/33/13 | 17/43/16 | 5/14/6 |
Zhang X | LC | 62/127/60 | 122/222/74 | 170/259/132 | 223/343/145 | 89/120/87 | 80/166/45 |
Cox DG | BC | 349/218/40 | 488/346/60 | 317/266/45 | 539/365/52 | 104/63/14 | 166/92/10 |
Quantitative synthesis
Subgroup | No. comparisons | TG vs. TT | GG vs. TT | GG vs. TT/TG | GG/TG vs. TT | ||||
---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | I-squre (%) | OR (95% CI) | I-squre (%) | OR (95% CI) | I-squre (%) | OR (95% CI) | I-squre (%) | ||
Total
|
78
|
1.10* (1.03-1.17)
|
51.7
|
1.25* (1.13-1.37)
|
66.9
|
1.18* (1.10-1.27)
|
55.1
|
1.14* (1.07-1.22)
|
62.2
|
Tumor site
| |||||||||
Breast
|
18
|
1.09* (1.00-1.19)
|
12.8
|
1.09 (0.96-1.24)
|
20.7
|
1.05 (0.94-1.17)
|
19.5
|
1.09* (1.01-1.17)
|
9.1
|
Lung
|
10
|
1.06 (0.93-1.22)
|
64.8
|
1.21 (0.99-1.47)
|
67.8
|
1.12 (0.99-1.27)
|
42.7
|
1.10 (0.95-1.27)
|
72.4
|
Ovarian
|
3
|
0.85 (0.63-1.16)
|
25.2
|
0.79 (0.48-1.28)
|
52.3
|
0.89 (0.63-1.25)
|
33.1
|
0.82 (0.57-1.18)
|
50.5
|
Pancreatic
|
2
|
1.55 (0.98-2.46)
|
59
|
1.56 (0.66-3.68)
|
74.6
|
1.24 (0.68-2.24)
|
56.4
|
1.54 (0.90-2.65)
|
73
|
Blood
|
4
|
1.08 (0.65-1.79)
|
79.4
|
1.11 (0.57-2.17)
|
80.3
|
1.09 (0.71-1.68)
|
63.8
|
1.10 (0.67-1.82)
|
81.6
|
Brain
|
5
|
1.47* (1.06-2.03)
|
57.6
|
1.18* (1.08-3.03)
|
69.5
|
1.38 (0.94-2.01)
|
55.9
|
1.51* (1.10-2.07)
|
61.3
|
Colorectal
|
6
|
1.14 (0.89-1.47)
|
51.2
|
1.05 (0.65-1.68)
|
74.4
|
1.00 (0.67-1.49)
|
70
|
1.13 (0.85-1.50)
|
65.5
|
Esophageal
|
2
|
1.11 (0.86-1.43)
|
36
|
1.26 (0.92-1.72)
|
51.2
|
1.28 (0.97-1.69)
|
63.1
|
1.18 (1.00-1.41)
|
0
|
Head-neck
|
4
|
0.92 (0.67-1.28)
|
71.6
|
1.01 (0.69-1.47)
|
72.3
|
1.11 (0.96-1.29)
|
1.7
|
0.94 (0.67-1.34)
|
77.8
|
Liver
|
4
|
1.57* (1.18-2.09)
|
0
|
2.24*(1.57-3.18)
|
0
|
1.65* (1.25-2.17)
|
0
|
1.76* (1.34-2.31)
|
0
|
Skin
|
4
|
1.00 (0.86-1.16)
|
0.4
|
1.05 (0.85-1.29)
|
1.2
|
1.05 (0.86-1.27)
|
0
|
1.01 (0.86-1.19)
|
26.6
|
Stomach
|
5
|
1.03 (0.75-1.42)
|
72.2
|
1.54* (1.04-2.29)
|
76.4
|
1.49* (1.20-1.84)
|
53.2
|
1.18 (0.84-1.65)
|
77.6
|
Uterus
|
8
|
0.95 (0.81-1.11)
|
0
|
1.34* (1.07-1.69)
|
5.3
|
1.26 (0.92-1.72)
|
51.2
|
0.81* (0.70-0.94)
|
0
|
Other
|
3
|
0.98 (0.72-1.32)
|
14.6
|
1.14 (0.63-2.08)
|
66.8
|
1.16 (0.72-1.85)
|
62.6
|
1.02 (0.67-1.52)
|
55
|
Racial descent
| |||||||||
African
|
3
|
1.22 (0.80-1.86)
|
61.2
|
0.75 (0.40-1.41)
|
0
|
0.73 (0.39-1.36)
|
0
|
1.16 (0.80-1.70)
|
56
|
European
|
34
|
1.05 (0.98-1.13)
|
34.8
|
1.13* (1.01-1.25)
|
40.8
|
1.10* (1.00-1.20)
|
30.8
|
1.08* (1.00-1.16)
|
42.1
|
Asian
|
32
|
1.11 (0.99-1.24)
|
58.4
|
1.36* (1.18-1.56)
|
68.6
|
1.27* (1.15-1.40)
|
58.6
|
1.18* (1.05-1.32)
|
65.8
|
Mixed
|
9
|
1.10 (0.91-1.32)
|
49.7
|
1.16 (0.86-1.56)
|
59.6
|
1.08 (0.88-1.35)
|
37.3
|
1.10 (0.92-1.32)
|
52.7
|
p53 mutation status
| |||||||||
Positive
|
7
|
1.09 (0.89-1.34)
|
0
|
1.17 (0.75-1.82)
|
59.4
|
1.09 (0.70-1.69)
|
70.3
|
1.12 (0.92-1.36)
|
0
|
Negative
|
7
|
1.06 (0.85-1.30)
|
4.1
|
0.95 (0.72-1.25)
|
0
|
0.97 (0.76-1.22)
|
0
|
1.03 (0.85-1.25)
|
0
|
Gene-gene interaction
MDM2 309T > G |
P53 72Arg > Pro | Case | Control | OR (95% CI) |
---|---|---|---|---|
TT | Arg/Arg | 469 | 762 | Reference |
TT | Arg/Pro | 457 | 791 | 1.09 (0.74-1.61) |
TT | Pro/Pro | 139 | 201 | 1.38 (0.92-2.06) |
TG | Arg/Arg | 646 | 1015 | 1.32 (0.88-1.98) |
TG | Arg/Pro | 785 | 1048 | 1.51 (0.96-2.38) |
TG | Pro/Pro | 304 | 349 | 1.88 (1.26-2.81)* |
GG | Arg/Arg | 307 | 348 | 1.96 (1.01-3.78)* |
GG | Arg/Pro | 339 | 446 | 1.53 (0.92-2.53) |
GG | Pro/Pro | 198 | 108 | 3.38 (1.77-6.47)* |
Test of heterogeneity
Publication bias
Comparison type | Intercept value | t-value | P-value | 95% CI of intercept value |
---|---|---|---|---|
TG vs. TT | 0.24 | 0.67 | 0.507 | -0.49 ~ 0.98 |
GG vs. TT | -0.07 | -0.16 | 0.87 | -0.91 ~ 0.77 |
GG vs. TT/TG | -0.22 | -0.6 | 0.55 | -0.94 ~ 0.51 |
GG/TG vs. TT | 0.35 | 0.87 | 0.39 | -0.45 ~ 1.15 |