Background
Methods
shRNA lentivirus-mediated silencing and overexpression of Snail in gastric cancer cells
Real time RT-PCR analysis of VEGF, MMP11, and Snailin gastric cancer cells
Western blotting
Cell migration and Matrigel invasion assay
Tissue microarrays, immunohistochemistry, and interpretation of results
Clinicopathological and survival analysis of gastric cancer patients
cDNA microarray analysis of GC tissues based on Snail overexpression
Results
Regulation of migration and invasion of gastric cancer cells by Snail
Effect of Snail overexpression on tumor aggressiveness and GC patient survival
Number of patients (N = 314) | Snail Positivity |
Pvalue | ||
---|---|---|---|---|
<75% | ≥75% | |||
Age (years) | 58.5 ± 10.6 | 59.1 ± 11.9 | 0.695 | |
Sex | ||||
Male | 218 | 143 | 75 | 0.996 |
Female | 96 | 63 | 33 | |
Tumor size | ||||
≤4.0 cm | 192 | 135 | 57 | 0.028 |
>4.0 cm | 122 | 71 | 51 | |
Location | ||||
Upper/Middle | 167 | 112 | 55 | 0.561 |
Lower | 147 | 94 | 53 | |
Invasion depth | ||||
T1 | 160 | 127 | 33 | < 0.001 |
T2 | 41 | 26 | 15 | |
T3 | 68 | 33 | 35 | |
T4 | 43 | 19 | 24 | |
Gross type | ||||
Elevated | 77 | 51 | 26 | < 0.001 |
Flat/depressed | 131 | 105 | 26 | |
Excavated | 106 | 50 | 56 | |
Histological type | ||||
Intestinal | 182 | 123 | 59 | 0.609 |
Diffuse | 122 | 76 | 46 | |
Mixed | 10 | 7 | 3 | |
Perineural invasion | ||||
Negative | 202 | 150 | 52 | < 0.001 |
Positive | 111 | 55 | 56 | |
Lymphovascular emboli | ||||
Negative | 193 | 139 | 54 | 0.002 |
Positive | 120 | 66 | 54 | |
Lymph node metastasis | ||||
N0, N1 | 270 | 186 | 84 | 0.002 |
N2, N3 | 44 | 20 | 24 |
Variables | B | SE | HR (95% CI) |
P
|
---|---|---|---|---|
Age (≤59 versus > 59) | -0.438 | 0.264 | 0.645 (0.385-1.082) | 0.097 |
Gender (male versus female) | -0.037 | 0.267 | 0.963 (0.571-1.626) | 0.889 |
Site (upper and middle versus lower) | 0.635 | 0.264 | 1.887 (1.126-3.164) | 0.016 |
Lauren (intestinal vs diffuse) | -0.537 | 0.263 | 0.585 (0.349-0.978) | 0.041 |
Snail (≥75% versus <75%) | -0.528 | 0.248 | 0.590 (0.363-0.958) | 0.033 |
Identification of gene expression patterns based on Snail overexpression using cDNA microarrays
PROBE_ID | SYMBOL | NAME |
---|---|---|
Genes upregulated in specimens with higher levels (≥75%) of Snail expression (P< 0.05) | ||
ILMN_2374449 |
SPP1
| Secreted phosphoprotein 1 |
ILMN_2337923 |
TPD52L1
| Tumor protein D52-like 1 |
ILMN_1679838 |
WBP5
| WW domain binding protein 5 |
ILMN_2078592 |
C6orf105
| Androgen-dependent TFPI-regulating protein |
ILMN_1714383 |
TPD52L1
| Tumor protein D52-like 1 |
ILMN_1674817 |
C1orf115
| Chromosome 1 open reading frame 115 |
ILMN_1813561 |
SCIN
| Scinderin |
ILMN_1759818 |
SORL1
| Sortilin-related receptor, L(DLR class) A repeats containing |
ILMN_1745686 |
MFHAS1
| Malignant fibrous histiocytoma amplified sequence 1 |
ILMN_2060115 |
SORL1
| Sortilin-related receptor, L(DLR class) A repeats containing |
ILMN_2337263 |
PKIB
| Protein kinase (cAMP-dependent, catalytic) inhibitor beta |
ILMN_2173835 |
FTHL3
| Ferritin, heavy polypeptide 1 pseudogene 3 |
ILMN_1791057 |
IFNAR2
| Interferon (alpha, beta and omega) receptor 2 |
ILMN_1807114 |
LOC255620
| Similar to unc-93 homolog B1 (C. elegans), transcript variant 1 (LOC255620), mRNA |
ILMN_1669393 |
GGT1
| Gamma-glutamyltransferase 1 |
ILMN_1685798 |
MAGEA6
| Melanoma antigen family A, 6 |
ILMN_3269395 |
GGT2
| Gamma-glutamyltransferase 2 |
ILMN_1669833 |
SH2B2
| SH2B adaptor protein 2 |
ILMN_3238534 |
LOC100133817
| Hypothetical protein LOC100133817 |
ILMN_2099315 |
TRPM8
| Transient receptor potential cation channel, subfamily M, member 8 |
ILMN_3298065 |
LOC729195
| Similar to apical early endosomal glycoprotein |
ILMN_1717726 |
FLJ43752
| Long intergenic non-protein coding RNA 336 |
ILMN_1670452 |
ANKRD20A1
| Ankyrin repeat domain 20 family, member A1 |
ILMN_3201060 |
LOC100132655
| Hypothetical protein LOC100132655 |
ILMN_3282829 |
LOC727913
| Similar to iduronate 2-sulfatase (Hunter syndrome) |
ILMN_2339691 |
SYVN1
| Synovial apoptosis inhibitor 1, synoviolin |
ILMN_1785549 |
SLC30A2
| Solute carrier family 30 (zinc transporter), member 2 |
ILMN_3191898 |
LOC100129630
| Hypothetical LOC100129630 |
ILMN_1704204 |
LOC642204
| Ankyrin repeat domain-containing protein 26-like |
ILMN_1682280 |
LOC647753
| Hypothetical protein LOC647753 |
ILMN_3201944 |
LOC646438
| Hypothetical LOC646438 |
ILMN_2233314 |
SPANXA1
| Sperm protein associated with the nucleus, X-linked, family member A1 |
ILMN_3305980 |
NS3BP
| NS3BP |
ILMN_1747850 |
CRIM2
| Kielin/chordin-like protein |
ILMN_1700590 |
LOC645590
| Similar to cAMP-dependent protein kinase type I-beta regulatory subunit |
ILMN_1766316 |
FLJ32679
| Golgin-like hypothetical protein LOC440321 |
ILMN_1890741 |
Hs.552561
| Pancreatic islet cDNA clone hbt09690 3, mRNA sequence |
ILMN_3308255 |
MIR33A
| MicroRNA 33a |
ILMN_1815716 |
LMLN
| Leishmanolysin-like (metallopeptidase M8 family) |
ILMN_1654945 |
DNMT3A
| DNA (cytosine-5-)-methyltransferase 3 alpha |
ILMN_2256050 |
SERPINA1
| Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
ILMN_1759487 |
EGFLAM
| EGF-like, fibronectin type III and laminin G domains |
ILMN_1760410 |
LOC653086
| Similar to RAN-binding protein 2-like 1 isoform 2 |
ILMN_1668969 |
MIXL1
| Mix paired-like homeobox |
ILMN_3279757 |
LOC100132532
| Hypothetical protein LOC100132532 |
ILMN_1715372 |
CAMKK1
| Calcium/calmodulin-dependent protein kinase kinase 1, alpha |
ILMN_1731370 |
C9orf84
| Chromosome 9 open reading frame 84 |
ILMN_1679049 |
COLEC12
| Collectin sub-family member 12 |
ILMN_1676011 |
LOC642561
| Similar to FXYD domain-containing ion transport regulator 6 |
ILMN_1815442 |
LOC652875
| Similar to Protein KIAA0685 |
ILMN_1737213 |
LOC653641
| Golgin A6 family, member C |
ILMN_1793529 |
LOC389031
| Myosin |
ILMN_1709319 |
C13orf39
| Methyltransferase like 21C |
ILMN_2284930 |
FLJ40296
| Proline rich 20A |
ILMN_1678310 |
TXNRD3IT1
| Thioredoxinreductase 3 neighbor |
ILMN_1806052 |
UNC119
| unc-119 homolog (C. elegans) |
ILMN_2242345 |
LPAL2
| Lipoprotein, Lp(a)-like 2, pseudogene |
ILMN_1687725 |
C17orf41
| ATPase family, AAA domain containing 5 |
ILMN_1886395 |
Hs.574341
| Soares_multiple_sclerosis_2NbHMSP Homo sapienscDNA clone IMAGp998G11618; IMAGE:126826, mRNA sequence |
ILMN_3308612 |
MIR149
| MicroRNA 149 |
ILMN_1811103 |
PCDHGB5
| Protocadherin gamma subfamily B, 5 |
ILMN_1736104 |
LOC645218
| Hypothetical LOC645218 |
ILMN_1824307 |
Hs.571901
| Full-length cDNA clone CS0DF20YK03 of Fetal brain of Homo sapiens
|
ILMN_1803871 |
RHO
| Rhodopsin |
ILMN_3237314 |
LOC732402
| Similar to butyrate-induced transcript 1 |
ILMN_1714191 |
LOC652682
| Similar to Y46G5A.1a |
ILMN_3246580 |
LOC730429
| e3 ubiquitin-protein ligase UBR5-like |
ILMN_3229028 |
LOC728586
| hCG1981531 |
ILMN_3239734 |
LOC100134822
| Uncharacterized LOC100134822 |
ILMN_1769785 |
SH3MD4
| SH3 domain containing ring finger 3 |
ILMN_3309864 |
MIR449B
| MicroRNA 449b |
ILMN_1653927 |
SNORD83A
| small nucleolar RNA, C/D box 83A |
ILMN_3200648 |
LOC151174
| uncharacterized LOC151174 |
ILMN_1652023 |
AGFG2
| ArfGAP with FG repeats 2 |
ILMN_1749776 |
LOC642816
| Similar to hypothetical protein LOC284701 |
ILMN_1671985 |
LOC646829
| Hypothetical protein LOC646829 |
ILMN_1684499 |
LOC650373
| Similar to deubiquitinating enzyme 3 |
ILMN_1676452 |
ADAMTS14
| ADAM metallopeptidase with thrombospondin type 1 motif, 14 |
ILMN_1723855 |
LOC390427
| Similar to TBP-associated factor 15 isoform 1 |
ILMN_1658019 |
LOC648447
| Hypothetical protein LOC648447 |
ILMN_3227291 |
LOC728701
| Hypothetical LOC728701 |
ILMN_1767469 |
LOC650781
| Hypothetical protein LOC650781 |
Genes downregulated in specimens with higher levels (≥75%) of Snail expression (P< 0.05) | ||
ILMN_1796946 |
ALLC
| Allantoicase |
ILMN_3248008 |
LOC442308
| Tubulin, beta class I pseudogene |
ILMN_3230623 |
FLJ40039
| Uncharacterized LOC647662 |
ILMN_1676596 |
LOC642263
| Hypothetical LOC642263 |
ILMN_3165745 |
ERCC-00084
| Synthetic construct clone NISTag41 external RNA control sequence |
ILMN_3242420 |
HCG8
| HLA complex group 8 |
ILMN_1783827 |
LOC649397
| Similar to Tripartite motif protein 44 (DIPB protein) (Mc7 protein) |
ILMN_3244733 |
LOC100131898
| Hypothetical protein LOC100131898 |
ILMN_3195376 |
LOC100130092
| Similar to MAPRE1 protein |
ILMN_2123683 |
FLJ43763
| Uncharacterized LOC642316 |
ILMN_1730601 |
FAM194A
| Family with sequence similarity 194, member A |
ILMN_1652015 |
LOC647451
| Similar to heat shock protein 90Bf |
ILMN_1784349 |
LOC647191
| Similar to Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein) |
ILMN_3251375 |
WBP11P1
| WW domain binding protein 11 pseudogene 1 |
ILMN_1911713 |
Hs.550068
| UI-E-EJ1-ajn-i-16-0-UI.s1 UI-E-EJ1 Homo sapienscDNA clone UI-E-EJ1-ajn-i-16-0-UI.3, mRNA sequence |
ILMN_1888057 |
Hs.554470
| nc63e05.r1 NCI_CGAP_Pr1 Homo sapienscDNA clone IMAGE:745952, mRNA sequence |
ILMN_3229818 |
LOC729828
| Misc_RNA (LOC729828), miscRNA |
ILMN_1654987 |
HCG2P7
| HLA complex group 2 pseudogene 7 |
ILMN_1683453 |
FRAS1
| Fraser syndrome 1 |
ILMN_1840493 |
Hs.112932
| ag03b01.s1 Soares_testis_NHTHomo sapienscDNA clone IMAGE:1056169 3, mRNA sequence |
ILMN_1860820 |
Hs.126468
| tm27h01.x1 Soares_NFL_T_GBC_S1 Homo sapienscDNA clone IMAGE:2157841 3, mRNA sequence |
ILMN_3227213 |
LOC728940
| Hypothetical LOC728940 |
ILMN_3247774 |
LOC100134235
| Similar to hCG1642820 |
ILMN_1902571 |
Hs.557622
| tw46h08.x1 NCI_CGAP_Ut1 Homo sapienscDNA clone IMAGE:2262783 3 similar to contains PTR5.b2 PTR5 repetitive element, mRNA sequence |
ILMN_2384405 |
RTBDN
| Retbindin |
ILMN_3234879 |
LOC653786
| Otoancorinpseudogene |
ILMN_1914891 |
Hs.334272
| RST40254 Athersys RAGE Library Homo sapienscDNA, mRNA sequence |
ILMN_3272356 |
LOC100129315
| Hypothetical protein LOC100129315 (LOC100129315), mRNA |
ILMN_3230388 |
LOC100130855
| Hypothetical protein LOC100130855( LOC100130855), mRNA |
ILMN_1656553 |
LOC653160
| Hypothetical protein LOC653160, transcript variant (LOC653160), mRNA |
ILMN_1700935 |
HAS2
| Hyaluronan synthase 2 |
ILMN_1733783 |
LOC652790
| Similar to anaphase promoting complex subunit 1 |
ILMN_2209221 |
DMRT1
| Doublesex and mab-3 related transcription factor 1 |
ILMN_1815118 |
ZNF554
| Zinc finger protein 554 |
ILMN_3293210 |
LOC100131031
| Similar to hCG2041190 (LOC100131031), mRNA |
ILMN_1703222 |
FRS2
| Fibroblast growth factor receptor substrate 2 |
ILMN_1732807 |
GPRC6A
| G protein-coupled receptor, family C, group 6, member A |
ILMN_1875332 |
Hs.545527
| he15g04.x1 NCI_CML1 Homo sapienscDNA clone IMAGE:2919216 3 similar to contains element PTR5 repetitive element |
ILMN_3235789 |
BPY2C
| Basic charge, Y-linked, 2C |
ILMN_3203116 |
LOC100131961
| Misc_RNA (LOC100131961), miscRNA |
ILMN_2198802 |
FAM22G
| Family with sequence similarity 22, member G |
ILMN_1858700 |
Hs.538558
| zh20c06.s1 Soares_pineal_gland_N3HPG Homo sapienscDNA clone IMAGE:412618 3, mRNA sequence |
ILMN_1873107 |
Hs.282800
| AV649053 GLC Homo sapienscDNA clone GLCBPH07 3, mRNA sequence |
ILMN_1891673 |
Hs.164254
| hb73c02.x1 NCI_CGAP_Ut2 Homo sapienscDNA clone IMAGE:2888834 3, mRNA sequence |
ILMN_3206632 |
LOC643802
| u3 small nucleolarribonucleoprotein protein MPP10-like |
ILMN_1883034 |
Hs.546089
| RST29145 Athersys RAGE Library Homo sapienscDNA, mRNA sequence |
ILMN_2373335 |
LIG3
| Ligase III, DNA, ATP-dependent |
ILMN_3239639 |
CD200R1L
| CD200 receptor 1-like |
ILMN_1870857 |
Hs.148168
| Barstead spleen HPLRB2 Homo sapienscDNA clone IMAGp998L113601 ; IMAGE:1425178, mRNA sequence |
ILMN_1813909 |
CRSP2
| Mediator complex subunit 14 |
ILMN_1891885 |
Hs.332843
| qg83a07.x1 Soares_NFL-T_GBC_S1 Homo sapienscDNA clone IMAGE:1841748, mRNA sequence |
ILMN_3235126 |
LOC100133558
| Similar to hCG1642170 |
ILMN_1677186 |
MGC52498
| Family with sequence similarity 159, member A |
ILMN_3252608 |
HCRP1
| Hepatocellular carcinoma-related HCRP1 |
ILMN_1652871 |
PLSCR5
| Phospholipid scramblase family, member 5 |
ILMN_1698894 |
OR5AS1
| Olfactory receptor, family 5, subfamily AS, member 1 |
ILMN_1705828 |
RICTOR
| RPTOR independent companion of MTOR, complex 2 |
ILMN_1683046 |
OR6Y1
| Olfactory receptor, family 6, subfamily Y, member 1 |
ILMN_2114812 |
ONECUT1
| One cut homeobox 1 |
ILMN_1770248 |
PDLIM2
| PDZ and LIM domain 2 (mystique) |
ILMN_1784272 |
CD1E
| CD1e molecule |
ILMN_1755635 |
FLJ33534
| Hypothetical protein FLJ33534 (FLJ33534), mRNA |
ILMN_1799067 |
TRY1
| Protease, serine, 1 (trypsin 1) |
ILMN_1693448 |
LOC643811
| Similar to FERM domain containing 6 |
ILMN_1723323 |
HCG4
| HLA complex group 4 (non-protein coding) |
ILMN_1865604 |
Hs.253267
| 60270330F1 NCI_CGAP_Skn3 Homo sapienscDNA clone IMAGE:4800534 5, mRNA sequence |
ILMN_3308698 |
MIR1276
| MicroRNA 1276 |
ILMN_1714014 |
LOC644491
| NMDA receptor regulated 2 pseudogene |
ILMN_2114185 |
C1orf104
| RUSC1 antisense RNA 1 (non-protein coding) |
ILMN_1911044 |
Hs.540915
| nf66b06.s1 NCI_CGAP_Co3 Homo sapienscDNA clone IMAGE:924851 3, mRNA sequence |
ILMN_1748543 |
STRC
| Stereocilin |
ILMN_1675221 |
DGKZ
| Diacylglycerol kinase, zeta |
ILMN_1726263 |
LOC653748
| Similar to dipeptidylaminopeptidase-like protein 6 (dipeptidylpeptidase VI) (dipeptidylpeptidase 6) (dipeptidyl peptidase VI-like protein) (dipeptidylaminopeptidase-related protein) (DPPX) |
ILMN_1817113 |
Hs.547985
| UI-H-BI0p-abm-h-10-0-UI.s1 NCI_CGAP_Sub2 Homo sapienscDNA clone IMAGE:2712450 3, mRNA sequence |
ILMN_1793525 |
KIR2DS3
| Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 |
ILMN_2415617 |
C10orf72
| V-set and transmembrane domain containing 4 |
ILMN_1746277 |
MLLT4
| Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 |
ILMN_1678246 |
LOC644001
| Hypothetical protein LOC644001 |
ILMN_3257856 |
LOC100130938
| Hypothetical LOC100130938 (LOC100130938), mRNA |
ILMN_1865630 |
Hs.116333
| Soares_testis_NHTHomo sapienscDNA clone IMAGp998A031828, mRNA sequence |
ILMN_2152028 |
LOC642452
| Hypothetical LOC642452 (LOC642452), mRNA |
ILMN_3244579 |
LOC649330
| Heterogeneous nuclear ribonucleoprotein C-like |
ILMN_1905832 |
Hs.564127
| UI-E-DW1-ahc-g-05-0-UI.r1 UI-E-DW1 Homo sapienscDNA clone UI-E-DW1-ahc-g-05-0-UI.5, mRNA sequence |
ILMN_1897251 |
Hs.547715
| UI-E-EJ0-ahv-e-11-0-UI.s1 UI-E-EJ0 Homo sapienscDNA clone UI-E-EJ0-ahv-e-11-0-UI 3, mRNA sequence |
ILMN_1782800 |
LOC651410
| Hypothetical protein LOC651410 |
ILMN_1732554 |
ZNF346
| Zinc finger protein 346 |
ILMN_1674014 |
LOC653878
| Similar to Cytosolic acyl coenzyme A thioester hydrolase, inducible (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I) (CTE-Ib) |
ILMN_1911501 |
Hs.543905
| xi89f08.x1 NCI_CGAP_Mel3 Homo sapienscDNA clone IMAGE:265999 3, mRNA sequence |
ILMN_1878305 |
Hs.262789
| xk07d09.x1 NCI_CGAP_Co20 Homo sapienscDNA clone IMAGE:2666033 3, mRNA sequence |
ILMN_1858245 |
Hs.156566
| Soares_testis_NHTHomo sapienscDNA clone IMAGp998M073519, mRNA sequence |
ILMN_1704313 |
GSTCD
| Glutathione S-transferase, C-terminal domain containing |
ILMN_1707398 |
ESRRB
| Estrogen-related receptor beta |
ILMN_3307954 |
L3MBTL4
| l(3)mbt-like 4 (Drosophila) |
ILMN_1851244 |
Hs.59368
| UI_H_BI1_aex-h-12-0-UI.s1 NCI_CGAP_Sub3 Homo sapienscDNA clone IMAGE:2720903 3, mRNA |
ILMN_1828556 |
Hs.541581
| nac23e12.x1 Lupski_sciatic_nerveHomo sapienscDNA clone IMAGE:3394270 3, mRNA sequence |
ILMN_1692894 |
LOC654042
| Similar to dehydrogenase/reductase (SDR family) member 4 like 2 |
ILMN_1893728 |
Hs.377660
|
Homo sapienscDNA FLJ26242 fis, clone DMC00770 |
ILMN_1667005 |
LOC652676
| Similar to similar to hypothetical protein FLJ36144 |
ILMN_3241607 |
LOC100132106
| Hypothetical LOC100132106 |
ILMN_1797503 |
GOLGA8G
| Golgin A8 family, member G |
ILMN_1828034 |
Hs.154513
| ik89c11.z1 Human insulinomaHomo sapienscDNA clone IMAGE:6027645 3, mRNA sequence |
ILMN_1886816 |
Hs.544491
| qq31a07.x1 Soraes_NhHMPu_S1 Homo sapienscDNA clone IMAGE:1934100 3, mRNA sequence |
ILMN_1847950 |
Hs.505398
| wq87c02.x1 NCI_CGAP_GC6 Homo sapienscDNA clone IMAGE:2479010 3, mRNA sequence |
ILMN_1734479 |
ACCN3
| Acid-sensing (proton-gated) ion channel 3 |
ILMN_1675025 |
H2BFM
| H2B histone family, member M |
ILMN_2073279 |
SIM1
| Single-minded homolog 1 (Drosophila) |
ILMN_1910185 |
Hs.98563
| zw57h03.s1 Soares_total_fetus_Nb2HF8_9w Homo sapienscDNA clone IMAGE:774197 3, mRNA sequence |
ILMN_3251491 |
UQCRB
| Ubiquinol-cytochrome c reductase binding protein |
ILMN_2180315 |
ATG4D
| ATG4 autophagy related 4 homolog D (S. cerevisiae) |
ILMN_1885583 |
Hs.542934
|
Homo sapienscDNA FLJ26431 fis, clone KDN01390 |
ILMN_1743301 |
MSR1
| Macrophage scavenger receptor 1 |
ILMN_1809820 |
LOC648963
| Similar to retinitis pigmentosa 1-like 1 |
ILMN_1869348 |
Hs.460114
| UI-E-EJ0-ahv-d-07-0-UI.s1 UI-E-EJ0 Homo sapienscDNA clone UI-E-EJ0-ahv-d-07-0-UI 3, mRNA sequence |
ILMN_1711332 |
TFEC
| Transcription factor EC |
ILMN_2228538 |
IRAK1BP1
| Interleukin-1 receptor-associated kinase 1 binding protein 1 |
ILMN_1756455 |
IL5RA
| Interleukin 5 receptor, alpha |
ILMN_1719202 |
ZNF174
| Zinc finger protein 174 |
ILMN_1847029 |
Hs.553290
| HESC3_84_D06.g1_A036 Human embryonic stem cells Homo sapienscDNA clone IMAGE:7483454 5, mRNA sequence |
ILMN_1740217 |
HACE1
| HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 |
ILMN_1787464 |
LOC651296
| Similar to RAB, member of RAS oncogene family-like 2B isoform 1 |
ILMN_1734096 |
DCLRE1A
| DNA cross-link repair 1A |
ILMN_2391333 |
CYP20A1
| Cytochrome P450, family 20, subfamily A, polypeptide 1 |
ILMN_2226314 |
DBR1
| Debranching enzyme homolog 1 (S. cerevisiae) |
ILMN_2379560 |
CDC14B
| CDC14 cell division cycle 14 homolog B (S. cerevisiae) |
ILMN_2078466 |
DZIP1L
| DAZ interacting protein 1-like |
ILMN_1653039 |
LOC642934
| Hypothetical protein LOC642934 (LOC642934), mRNA |
ILMN_2044293 |
KBTBD7
| Kelch repeat and BTB (POZ) domain containing 7 |
ILMN_1809951 |
ZNF200
| Zinc finger protein 200 |
ILMN_1760280 |
NXT1
| NTF2-like export factor 1 |
ILMN_1657796 |
STMN1
| Stathmin 1 |
ILMN_1793578 |
ZFP37
| Zinc finger protein 37 homolog (mouse) |
Probe ID | Gene acronym | Gene name | Accession No. |
Pvalue |
---|---|---|---|---|
Cancer cell–ECM adhesion | ||||
ILMN_1759487 |
EGFLAM
| EGF-like, fibronectin type III, and laminin G domains (↑) | NM_182801 | 0.005 |
ILMN_2114812 |
ONECUT1
| One cut homeobox 1 (↓) | NM_004498 | 0.002 |
ILMN_2374449 |
SPP1
| Secreted phosphoprotein 1 (↑) | NM_000582 | 0.004 |
ECM protein regulation | ||||
ILMN_1676452 |
ADAMTS14
| ADAM metallopeptidase with thrombospondin type 1 motif, 14 (↑) | NM_080722 | 0.005 |
ILMN_1759487 |
EGFLAM
| EGF-like, fibronectin type III, and laminin G domains (↑) | NM_182801 | 0.005 |
ILMN_1683453 |
FRAS1
| Fraser syndrome 1 (↓) | NM_020875 | 0.003 |
ILMN_1791057 |
IFNAR2
| Interferon (alpha, beta, and omega) receptor 2 (↑) | NM_207585 | 0.001 |
ILMN_1756455 |
IL5RA
| Interleukin 5 receptor, alpha (↓) | NM_000564 | 0.004 |
ILMN_1747850 |
CRIM2
| Kielin/chordin-like protein (↑) | NM_199349 | 0.005 |
ILMN_1743301 |
MSR1
| macrophage scavenger receptor 1 (↓) | NM_002445 | 0.002 |
ILMN_2374449 |
SPP1
| secreted phosphoprotein 1 (↑) | NM_000582 | 0.004 |
ILMN_2256050 |
SERPINA1
| Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (↑) | NM_000295 | 0.002 |
ILMN_2060115, ILMN_1759818 |
SORL1
| Sortilin-related receptor, L(DLR class) A repeats-containing (↑) | NM_003105 | 0.003 <0.001 |