Introduction
Methods
Statistical methods
Results
All patients | Q I | Q II | Q III | Q IV | Q V |
P
| ||
---|---|---|---|---|---|---|---|---|
n
|
585
|
117
|
117
|
117
|
117
|
117
| ||
log
(TG). HDL-C
-1
|
0.053
|
0.032
|
0.042
|
0.050
|
0.060
|
0.082
|
~
| |
age
| years |
65 (12)
|
67 (12)
|
67 (12)
|
63 (12)
|
65 (12)
|
63 (10)
|
0.0083
|
smoking *
| % |
36/64
|
41/59
|
44/56
|
40/60
|
31/69
|
24/76
|
0.0010
|
ethanol
| U.week-1 |
16 (23)
|
21 (25)
|
19 (21)
|
16 (24)
|
14 (21)
|
11 (25)
|
0.0093
|
LT physical activity **
| % |
60/40
|
55/45
|
53/47
|
58/42
|
67/33
|
68/32
|
0.0072
|
LT screen watching ***
| hr.day-1 |
3.1 (1.8)
|
2.7 (1.8)
|
2.8 (1.6)
|
2.8 (1.6)
|
3.0 (1.5)
|
4.0 (2.2)
|
<0.0001
|
BMI
| kg.m-2 |
28.8 (5.1)
|
26.5 (4.9)
|
27.9 (4.5)
|
29.2 (5.0)
|
30.1 (5.0)
|
30.4 (5.3)
|
<0.0001
|
waist circumference
| cm |
105 (13)
|
98 (13)
|
103 (11)
|
105 (12)
|
109 (12)
|
109 (13)
|
<0.0001
|
conicity index
| m2.kg-1 |
1.35 (0.08)
|
1.33 (0.08)
|
1.35 (0.07)
|
1.36 (0.08)
|
1.37 (0.07)
|
1.37 (0.08)
|
0.0002
|
fat mass
| % |
27.4 (6.2)
|
25.0 (6.7)
|
26.9 (6.0)
|
27.5 (6.5)
|
28.6 (5.5)
|
28.8 (5.6)
|
<0.0001
|
visceral fat
| 0 - 30 |
14 (5)
|
12 (5)
|
13 (4)
|
14 (5)
|
15 (4)
|
15 (5)
|
<0.0001
|
liver steatosis
| % |
68
|
50
|
61
|
69
|
72
|
83
|
<0.0001
|
insulinaemia
| pmol.l-1 |
113 (77)
|
80 (47)
|
103 (67)
|
122 (98)
|
125 (83)
|
132 (71)
|
<0.0001
|
HOMA S
| % |
53 (34)
|
69 (39)
|
61 (40)
|
50 (30)
|
49 (30)
|
39 (23)
|
<0.0001
|
HOMA product (B × S)
| % |
28.5 (18.2)
|
35.7 (21.6)
|
31.1 (16.2)
|
26.7 (15.8)
|
26.7 (16.2)
|
22.5 (16.5)
|
<0.0001
|
(B × S) loss rate
| %.yr-1 |
1.29 (0.45)
|
1.15 (0.50)
|
1.18 (0.33)
|
1.38 (0.52)
|
1.28 (0.40)
|
1.44 (0.39)
|
<0.0001
|
metabolic syndrome
| % |
76
|
36
|
67
|
83
|
95
|
97
|
<0.0001
|
metabolic syndrome score
| 1/5 to 5/5 |
3.4
|
2.3
|
2.9
|
3.5
|
4.0
|
4.4
|
<0.0001
|
statin/fibrate
| % |
54/21
|
49/9
|
51/11
|
59/21
|
57/16
|
56/46
|
NS/<0.0001
|
macroangiopathy
| % |
40
|
29
|
38
|
44
|
40
|
48
|
0.006
|
CAD | % |
29
|
15
|
32
|
32
|
31
|
33
|
0.0097
|
TIA/stroke | % |
9
|
5
|
5
|
10
|
10
|
13
|
0.0129
|
PAD | % |
12
|
15
|
13
|
11
|
8
|
14
|
NS
|
All patients | Q I | Q II | Q III | Q IV | Q V |
P
| ||
---|---|---|---|---|---|---|---|---|
n
|
585
|
117
|
117
|
117
|
117
|
117
| ||
HbA
1c
| % |
7.53 (1.53)
|
7.32 (1.36)
|
7.41 (1.52)
|
7.48 (1.46)
|
7.60 (1.55)
|
7.85 (1.72)
|
NS
|
HbA
1c
< 7.0%
| % |
43
|
49
|
47
|
45
|
40
|
35
|
0.0155
|
cholesterol (C)
| mg.dl-1 |
175 (41)
|
179 (35)
|
180 (37)
|
168 (40)
|
174 (41)
|
174 (48)
|
NS
|
LDL-C
| mg.dl-1 |
98 (35)
|
100 (32)
|
107 (34)
|
96 (34)
|
97 (34)
|
90 (38)
|
0.0047
|
non-HDL-C
| mg.dl-1 |
131 (40)
|
118 (33)
|
132 (36)
|
127 (38)
|
136 (40)
|
143 (47)
|
<0.0001
|
non-HDL-C - LDL-C
| mg.dl-1 |
31 (18)
|
18 (8)
|
25 (11)
|
30 (15)
|
38 (18)
|
47 (21)
|
<0.0001
|
HDL-C
| mg.dl-1 |
44 (13)
|
61 (11)
|
48 (8)
|
42 (7)
|
38 (6)
|
32 (8)
|
~
|
apoA1
| mg.dl-1 |
143 (27)
|
167 (23)
|
151 (24)
|
139 (20)
|
137 (18)
|
122 (26)
|
<0.0001
|
apoB
100
| mg.dl-1 |
90 (26)
|
80 (23)
|
92 (26)
|
86 (24)
|
94 (25)
|
95 (30)
|
<0.0001
|
pre-LLD TG
| mg.dl-1 |
204 (155)
|
102 (46)
|
149 (61)
|
173 (82)
|
217 (72)
|
359 (254)
|
~
|
current TG
| mg.dl-1 |
171 (119)
|
92 (40)
|
129 (66)
|
153 (77)
|
200 (102)
|
282 (165)
|
~
|
LDL-C. apoB
100
-1
|
1.07 (0.28)
|
1.21 (0.24)
|
1.13 (0.26)
|
1.07 (0.26)
|
0.99 (0.28)
|
0.92 (0.27)
|
<0.0001
| |
hs
CRP
| mg.dl-1 |
0.36 (0.61)
|
0.36 (0.73)
|
0.20 (0.21)
|
0.42 (0.72)
|
0.35 (0.44)
|
0.48 (0.76)
|
0.0089
|
uric acid
| mg.dl-1 |
5.7 (1.6)
|
5.5 (1.4)
|
5.7 (1.5)
|
5.6 (1.7)
|
6.3 (1.6)
|
5.7 (1.6)
|
0.001
|
cystatin C
| mg.l-1 |
0.87 (0.34)
|
0.76 (0.21)
|
0.85 (0.22)
|
0.85 (0.27)
|
0.90 (0.38)
|
0.98 (0.48)
|
<0.0001
|
white blood cells
| 103.mm-3 |
7.20 (1.94)
|
6.63 (2.04)
|
6.70 (1.90)
|
7.49 (1.90)
|
7.57 (2.01)
|
7.56 (1.58)
|
<0.0001
|
ALT
| IU.l-1 |
32 (21)
|
27 (11)
|
33 (26)
|
30 (16)
|
38 (28)
|
32 (14)
|
0.0009
|
SHBG
| nmol.l-1 |
37 (24)
|
46 (25)
|
37 (21)
|
31 (15)
|
36 (25)
|
34 (30)
|
<0.0001
|
eGFR
| ml.min-1.1.73 m2 |
80 (27)
|
85 (25)
|
80 (23)
|
82 (29)
|
81 (24)
|
73 (30)
|
0.0105
|
albuminuria
| μg.mg creatinine-1 |
100 (278)
|
50 (103)
|
30 (55)
|
108 (273)
|
106 (304)
|
201 (433)
|
<0.0001
|
normal/(μ)albuminuria
| % |
65/35
|
76/24
|
73/27
|
64/36
|
63/37
|
51/49
|
<0.0001
|