Introduction
Materials and methods
Subjects
Genotyping
Statistical analysis
Results
Mild malaria (n = 192) | Cerebral malaria (n = 106) | Association P-valuea | |
---|---|---|---|
Genotype | |||
IL1B -31C>T | |||
C/C | 55 (0.286) | 28 (0.264) | 0.82 |
C/T | 91 (0.474) | 49 (0.462) | |
T/T | 46 (0.240) | 29 (0.274) | |
Allele | |||
IL1B -31C>T | |||
C | 201 (0.523) | 105 (0.495) | 0.55 |
T | 183 (0.477) | 107 (0.505) |
Mild malaria (n = 203) | Cerebral malaria (n = 109) | Association P-valuea | |
---|---|---|---|
Genotype | |||
2/2b | 2 (0.010) | 2 (0.018) | 0.88 |
2/4 | 42 (0.207) | 24 (0.220) | |
3/4 | 3 (0.015) | 1 (0.009) | |
4/4 | 154 (0.759) | 82 (0.752) | |
4/5 | 2 (0.010) | 0 (0.000) | |
Allele | |||
IL1RA
| |||
2 | 46 (0.113) | 28 (0.128) | 0.84 |
3 | 3 (0.007) | 1 (0.005) | |
4 | 355 (0.874) | 189 (0.867) | |
5 | 2 (0.005) | 0 (0.000) |
Haplotypea | Mild malaria | Cerebral malaria | Association P-valueb |
---|---|---|---|
IL1B – IL1RA | |||
-31C - 2c | 0.042 | 0.046 | 0.60 |
-31T - 2 | 0.072 | 0.084 | |
-31C - 4 | 0.432 | 0.454 | |
-31T - 4 | 0.443 | 0.414 |
Discussion
TNFA -308G>A | |||
---|---|---|---|
G/G | G/A | A/A | |
Mild malaria (n = 192) | |||
IL1B -31C>T | |||
C/Cb | 48 (0.250) | 7 (0.036) | 0 (0.000) |
C/T | 85 (0.443) | 6 (0.031) | 0 (0.000) |
T/T | 43 (0.224) | 3 (0.016) | 0 (0.000) |
Cerebralmalaria (n = 105) | |||
IL1B -31C>T | |||
C/C | 25 (0.238) | 2 (0.019) | 0 (0.000) |
C/T | 41 (0.390) | 8 (0.076) | 0 (0.000) |
T/T | 25 (0.238) | 3 (0.029) | 1 (0.009) |