Background
Methods
Study design
Participant recruitment
Treatment and follow-up
Laboratory analyses
Statistical analysis
Ethics
Results
Patient characteristics
Site | Mut | Yao | Gar | ||||||
---|---|---|---|---|---|---|---|---|---|
Drug Groups | SPAQ | SP | AQ | SPAQ | SP | AQ | SPAQ | SP | AQ |
Age (mean in months ± SD) | 29 ± 15.5 | 27 ± 14.8 | 27 ± 15.2 | 29.4 ± 14.5 | 30 ± 15.1 | 29 ± 13.8 | 27 ± 15.4 | 26.6 ± 16.5 | 27.4 ± 17.2 |
Female/Male ratio | 1 | 0.9 | 1 | 0.7 | 1.2 | 0.82 | 0.74 | 0.82 | 1.2 |
Weight (kg) (mean ± SD) | 12.5 ± 3.5 | 12.2 ± 3.2 | 12.2 ± 4.1 | 13.02 ± 3.0 | 12.6 ± 3.4 | 12.9 ± 3.2 | 10.84 ± 3.3 | 10.86 ± 2.7 | 10.59 ± 3.3 |
Geo mean parasitemia (± SD) | 39601 (± 48160) | 27014 (± 49560) | 22072 (± 30260) | 7776 (± 27120) | 6721 (± 25200) | 5364 (± 25720) | 7264 (± 27730) | 5668 (± 19040) | 6294 (± 26890) |
Temp °C (mean ± SD) | 38.9 ± 1.1 | 38.7 ± 1.1 | 38.7 ± 1.0 | 38.2 ± 1.2 | 38.3 ± 1.0 | 38.4 ± 1.2 | 37.9 ± 0.6 | 38.0 ± 0.6 | 37.7 ± 0.7 |
Safety, clinical and parasitological outcomes
Drug | Adverse Events | Frequency |
---|---|---|
SPAQ | Weakness | 1.25% |
Cough | 1.25% | |
Rashes | 0.84% | |
SP | Weakness | 1.25% |
Cough | 1.25% | |
Rashes | 0.84% | |
Anorexia | 0.84% | |
Diarrhea | 1.25% | |
AQ | Weakness | 02.5% |
Cough | 0.42% | |
Rashes | 0.42% |
Mutengene | Yaounde | Garoua | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Treatment | group | SPAQ | SP | AQ | SPAQ | SP | AQ | SPAQ | SP | AQ |
ETF | 4 | 14 | 3 | 0 | 8 | 1 | 3 | 10 | 10 | |
LCF | 2 | 7 | 4 | 2 | 12 | 4 | 2 | 5 | 1 | |
LPF | 6 | 11 | 6 | 10 | 12 | 8 | 6 | 7 | 8 | |
ACPR, D14 (PCR corrected) | 82.5% | 75.3% | 88.3% | 82.3% | 88.0% | 86.3% | 81.7% | 71.0% | 72.0% | |
ACPR, D28 (PCR corrected) | 81.9% | 62.5% | 79.2% | 76.2% | 67.5% | 80.3% | 80.9% | 70.1% | 71.2% | |
Gametocyte | D3 | 1 | 10 | 3 | 9 | 7 | 4 | 0 | 1 | 1 |
Carriage(n) | D7 | 2 | 11 | 4 | 7 | 14 | 6 | 0 | 2 | 1 |
D14 | 0 | 6 | 0 | 3 | 16 | 0 | 0 | 1 | 0 | |
D28 | 0 | 1 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | |
% | 2.4% | 13.9% | 5.0% | 8.9% | 14.5% | 7.1% | 0.0% | 2.9% | 1.4% |