Background
Methods
Patients and tissue
Characteristics | N (%) | |
---|---|---|
Histologic type | Serous | 60 (48.8) |
Mucinous | 25 (20.3) | |
Endometrioid | 11 (8.9) | |
Clear cell | 25 (20.3) | |
Undifferentiated | 2 (1.6) | |
Histologic grade | Grade 1 | 35 (28.5) |
Grade 2 | 62 (50.4) | |
Grade 3 | 26 (21.1) | |
Tumor size | <10 cm | 61 (49.6) |
≥10 cm | 62 (50.4) | |
Mitotic count | <10/10HPFs | 50 (40.6) |
10 ≤ but < 20/10HPFs | 44 (35.8) | |
≥20/10HPFs | 29 (23.6) | |
FIGO stage | I | 54 (43.9) |
II | 8 (6.5) | |
III | 44 (35.8) | |
IV | 17 (13.8) | |
Disease recurrence | No | 62 (50.4) |
Yes | 61 (49.6) | |
Survival | Alive | 92 (74.8) |
DOD | 31 (25.2) |
Immunohistochemistry
Statistical analysis
Results
TLR4 | MyD88 | NF-κB | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Positive | Negative |
P
| Positive | Negative |
P
| Positive | Negative |
P
| ||
Histologic type | Serous | 23 | 37 | 0.001 | 20 | 40 | 0.003 | 40 | 20 | 0.037 |
Mucinous | 6 | 19 | 5 | 20 | 15 | 10 | ||||
Endometrioid | 7 | 4 | 2 | 9 | 4 | 7 | ||||
Clear cell | 19 | 6 | 16 | 9 | 20 | 5 | ||||
Undifferentiated | 2 | 0 | 2 | 0 | 1 | 1 | ||||
Histologic grade | Grade 1 | 15 | 20 | 0.469 | 8 | 27 | 0.083 | 25 | 10 | 0.640 |
Grade 2 | 32 | 30 | 24 | 38 | 39 | 23 | ||||
Grade 3 | 10 | 16 | 13 | 13 | 16 | 10 | ||||
Tumor size | <10 cm | 26 | 35 | 0.471 | 24 | 37 | 0.577 | 39 | 22 | 0.851 |
≥10 cm | 31 | 31 | 21 | 41 | 41 | 21 | ||||
Mitotic count | <10/10HPFs | 25 | 25 | 0.569 | 16 | 34 | 0.660 | 35 | 15 | 0.541 |
10 ≤ but <20/10HPFs | 21 | 23 | 18 | 26 | 26 | 18 | ||||
≥20/10HPFs | 11 | 18 | 11 | 18 | 19 | 10 | ||||
FIGO stage | I/II | 26 | 36 | 0.368 | 16 | 46 | 0.015 | 38 | 24 | 0.451 |
III/IV | 31 | 30 | 29 | 32 | 42 | 19 | ||||
Disease recurrence | No | 27 | 35 | 0.589 | 16 | 46 | 0.015 | 40 | 22 | 0.526 |
Yes | 30 | 31 | 29 | 32 | 40 | 21 |
TLR4/MyD88 | TLR4/MyD88/NF-κB | ||||||
---|---|---|---|---|---|---|---|
Positive | Negative |
P
| Positive | Negative |
P
| ||
Histologic type | Serous | 12 | 48 | 0.000 | 10 | 50 | 0.002 |
Mucinous | 2 | 23 | 1 | 24 | |||
Endometrioid | 2 | 9 | 2 | 9 | |||
Clear cell | 13 | 12 | 12 | 13 | |||
Undifferentiated | 2 | 0 | 1 | 1 | |||
Histologic grade | Grade 1 | 4 | 31 | 0.074 | 3 | 32 | 0.058 |
Grade 2 | 20 | 42 | 18 | 44 | |||
Grade 3 | 7 | 19 | 5 | 21 | |||
Tumor size | <10 cm | 17 | 44 | 0.539 | 13 | 48 | 0.569 |
≥10 cm | 14 | 48 | 13 | 49 | |||
Mitotic count | <10/10HPFs | 10 | 40 | 0.415 | 9 | 41 | 0.707 |
10 ≤ but < 20/10HPFs | 14 | 30 | 11 | 33 | |||
≥20/10HPFs | 7 | 22 | 6 | 23 | |||
FIGO stage | I/II | 10 | 52 | 0.023 | 8 | 54 | 0.028 |
III/IV | 21 | 40 | 18 | 43 | |||
Disease recurrence | No | 13 | 49 | 0.305 | 11 | 51 | 0.384 |
Yes | 18 | 43 | 15 | 46 |
TLR4 | MyD88 | NF-κB | ||
---|---|---|---|---|
TLR4 | Pearson Correlation | - | 0.343 | 0.066 |
0.000 | 0.469 | |||
P value | ||||
MyD88 | Pearson Correlation | - | - | 0.097 |
0.287 | ||||
P value |
Protein | Expression | Means for survival time (months) | 95% CI | P value | |
---|---|---|---|---|---|
Lower | Upper | ||||
TLR4 | Positive | 88.3 | 72.5 | 104.1 | 0.030 |
Negative | 113.1 | 97.8 | 128.4 | ||
MyD88 | Positive | 65.2 | 51.2 | 79.2 | 0.000 |
Negative | 121.1 | 109.4 | 132.8 | ||
TLR4/MyD88 | Positive | 59.1 | 43.7 | 74.5 | 0.000 |
Negative | 113.9 | 101.9 | 125.9 | ||
TLR4/MyD88/ NF-κB | Positive | 56.5 | 39.5 | 73.5 | 0.000 |
Negative | 112.0 | 100.0 | 124.0 |
Protein | P value | Ratio of risk | 95% CI | |
---|---|---|---|---|
lower | upper | |||
TLR4 | 0.168 | 0.409 | 0.115 | 1.457 |
MyD88 | 0.004 | 0.128 | 0.032 | 0.513 |
TLR4/MyD88 | 0.438 | 2.580 | 0.235 | 28.300 |
TLR4/MyD88/NF-κB | 0.551 | 0.553 | 0.079 | 3.883 |