Background
Methods
Tissue sample
Immunohistochemistry
Statistical analysis
Results
MUC1, MUC2, and MUC4 expression profile in gallbladder carcinoma
MUC4 expression | |||||
---|---|---|---|---|---|
- | + | ++ | +++ | P-value | |
MUC1 expression | |||||
- | 8 | 2 | 0 | 2 | 0.004 |
+ | 3 | 3 | 0 | 0 | |
++ | 5 | 8 | 0 | 1 | |
+++ | 12 | 3 | 8 | 14 | |
MUC2 expression | |||||
- | 24 | 7 | 5 | 9 | 0.009 |
+ | 4 | 2 | 2 | 5 | |
++ | 0 | 0 | 1 | 2 | |
+++ | 0 | 1 | 0 | 1 |
MUC1 | MUC2 | MUC4 | ||||
---|---|---|---|---|---|---|
Number (%) | P-value | Number (%) | P-value | Number (%) | P-value | |
Gender
| ||||||
Male (n = 17) | 13 (77) | 0.7191 | 2 (12) | 0.1161 | 10 (59) | 0.7512 |
Female (n = 46) | 38 (83) | 16 (35) | 25 (54) | |||
Age, years
| ||||||
< 65 (n = 26) | 20 (77) | 0.5301 | 7 (27) | 0.8082 | 13 (50) | 0.4572 |
≥ 65 (n = 26) | 31 (84) | 11 (30) | 22 (60) | |||
Differentiation
| ||||||
Well (n = 25) | 19 (76) | 0.5171 | 5 (20) | 0.2222 | 11 (44) | 0.1342 |
Moderate/poor (n = 38) | 32 (84) | 13 (34) | 24 (63) | |||
Lymph node metastasis
| ||||||
Negative (n = 28) | 22 (79) | 1.0001 | 11 (39) | 0.1282 | 13 (46) | 0.4202 |
Positive (n = 17) | 14 (82) | 3 (18) | 10 (59) | |||
Depth of invasion
| ||||||
T1/T2 (n = 34) | 27 (79) | 0.7362 | 10 (29) | 0.8732 | 18 (53) | 0.6512 |
T3/T4 (n = 29) | 24 (83) | 8 (28) | 17 (59) |
Prognostic significance of MUC4, MUC1, and MUC2 expression in gallbladder carcinoma
Factors | Patients alive at 5 years, % | P-value |
---|---|---|
Age, years
| 0.0986 | |
< 5 | 60.8 | |
≥ 65 | 46.2 | |
Gender
| 0.9016 | |
Male | 42.9 | |
Female | 47.9 | |
Differentiation
| 0.0013 | |
Good | 81.9 | |
Moderate/poor | 25.2 | |
MUC1 expression
| 0.8882 | |
Negative | 37.3 | |
Positive | 56.3 | |
MUC2 expression
| 0.1288 | |
Negative | 43.7 | |
Positive | 56.3 | |
MUC4 expression
| 0.0478 | |
Negative | 62.3 | |
Positive | 31.5 | |
T stage
| 0.0008 | |
T1/T2 | 69.3 | |
T3/T4 | 19.9 | |
LN metastasis
| 0.0001 | |
Negative | 78.5 | |
Positive | 23.3 |
Factors | Risk ratio | 95% CI | P-value |
---|---|---|---|
MUC4
| |||
Negative | 1 | ||
Positive | 2.890 | 0.884- 9.451 | 0.079 |
Lymph node metastasis
| |||
Negative | 1 | ||
Positive | 3.508 | 0.860- 14.308 | 0.080 |
T stage
| |||
T1/T2 | 1 | ||
T3/T4 | 1.626 | 0.381- 6.940 | 0.511 |
Differentiation
| |||
Well | 1 | ||
Moderate/poor | 2.589 | 0.443- 15.135 | 0.291 |
Factors | Risk ratio | 95% CI | P-value |
---|---|---|---|
MUC4 expression
| |||
Negative | 1 | ||
Positive | 3.268 | 1.063 10.047 | 0.039 |
Lymph node metastasis
| |||
Negative | 1 | ||
Positive | 6.937 | 2.249 21.393 | 0.001 |