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Erschienen in: World Journal of Surgical Oncology 1/2014

Open Access 01.12.2014 | Case report

Breast hemangioma with difficulty in preoperative diagnosis: a case report

verfasst von: Naotake Funamizu, Isao Tabei, Chikako Sekine, Azusa Fuke, Mitsuo Yabe, Hiroshi Takeyama, Tomoyoshi Okamoto

Erschienen in: World Journal of Surgical Oncology | Ausgabe 1/2014

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Abstract

We report a rare case of breast hemangioma found in a 70-year-old Japanese female. Before seeking medical attention, the patient noticed a hard mass in her right breast but denied associated symptoms. A mammography revealed a well-circumscribed, highly dense, lobular nodule located in the middle inter portion of the right breast. To verify this finding, we used ultrasonography which revealed an irregular, iso-echoic nodule measuring 10 mm in the same portion. Based on these findings, we suspected a malignancy and performed a core needle biopsy. Unexpectedly, a histological examination of the biopsy displayed normal vasculature, adipose, and mammary tissues. In order to make an accurate diagnosis, the mass was surgically excised under general anesthesia and sent to pathology. Pathological findings of the mass were positive for breast hemangioma, and the patient has had no recurrence of the disease for the past 24 months.
Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-12-313) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

NF and TO collected the data, images and clinical information. IT, HT and CS searched the relevant literatures. NF wrote the whole draft. IT, MY and AF performed the surgery. All authors approved the final manuscript.
Abkürzungen
ABC
aspiration biopsy cytology
CNB
core-needle biopsy
CT
computed tomography
MMG
mammography
MRI
magnetic resonance imaging
US
ultrasonography

Background

Breast hemangioma is a rare, benign vascular tumor that accounts for only 0.4% of all breast tumors [1]. Preoperatively, hemangiomas of the breast are difficult to diagnose using conventional imaging modalities since they lack pathognomonic characteristics. We report the case of a 70-year-old Japanese female with a breast hemangioma.

Case presentation

A 70-year-old Japanese female consulted a local hospital upon noticing a hard mass in her right breast, and was later referred to our hospital for diagnosis and treatment. The patient denied a family history of breast cancer, while her physical examination revealed a firm, mobile mass measuring 10 mm. No axillary lymphadenopathy or nipple discharge was observed. A mammography (MMG) was performed in the standard craniocaudal and mediolateral oblique positions. The MMG demonstrated a well-circumscribed, highly dense, lobular mass in the middle inner portion of the right breast (Figure 1a). No associated calcifications were present.We followed up the MMG with an US which revealed a poorly demarcated, iso-echoic lesion of 10 mm without any accompanying posterior echo attenuation (Figure 1b). Contrast-enhanced computed tomography (CT) showed a well-defined, enhanced mass at both the early and late phases (Figure 2a).Following variations in results, the patient underwent dynamic contrast-enhanced magnetic resonance imaging (MRI). T1-weighted images of the tumor displayed high signal intensity, while the dynamic contrast-enhanced MRI demonstrated a heterogeneous enhancement in both the early and delayed phases (Figure 2b). Based on our MRI findings, a preoperative diagnosis of occult breast cancer was suspected. Since these findings were highly suggestive of a malignant tumor, an aspiration biopsy cytology (ABC) was performed. An ABC analysis showed a poor specimen composed only of blood. A sonography-guided core-needle biopsy (CNB) was then performed and was positive for vascular, adipose and mammary tissues, but lacked evidence of a malignancy.As a result, a total excisional biopsy of the tumor in the inner portion of the right breast was performed under general anesthesia. The resected specimen (17 × 23 mm in size) was a firm, well-circumscribed mass with a brownish hue (Figure 3). A histological examination of the specimen revealed a breast hemangioma lacking cellular atypia (Figure 4). The postoperative course of the disease has remained recurrence-free for 25 months.

Discussion

Breast hemangioma is a rare, benign vascular tumor representing only 0.4% of all breast tumors [1]. Histologically, breast hemangiomas are classified as either diffuse or localized. Localized hemangiomas are further divided into the following subtypes: peri-lobular, parenchymal, subcutaneous and venous. The parenchymal subtype is classified into capillary and cavernous hemangiomas [2]. Peri-lobular hemangiomas are relatively common lesions that are generally small and impalpable [3]. The other two types of hemangiomas are rare [2]. When making a diagnosis of breast hemangioma, it is important to include hemangiosarcoma, lipoma, cysts, mucinous carcinomas and fibroadenoma in the differential. It should also be noted that an accurate preoperative diagnosis of breast hemangioma seems difficult using current imaging modalities, as well as ABC and CNB.
When looking at summarized patient reports, only three out of 27 breast hemangiomas have been diagnosed preoperatively [426]. Furthermore, women comprised 23 of these patients while men accounted for only four (age range 17 to 82 years; mean age 55.6 years). Moreover, the majority of masses in these patients appeared on an MMG as oval, or high-density, lobular lesions with well-circumscribed edges. With sonographic studies, 63.0% of these patients showed well-circumscribed, hypoechoic masses. In addition, vascularity on color Doppler sonography has not been found to have diagnostic value. As previously described, radiographic assistance in reaching the diagnosis has been limited. Breast hemangioma specimens analyzed by CNB or ABC were found to contain hematic material in 40.7% of patients (Additional file 1: Table S1). Unfortunately, these findings are unreliable for making an accurate diagnosis. Once a diagnosis is confirmed, surgical resection is curative since most breast hemangiomas have low malignant potential [3, 27]. Pathologically, it is important to distinguish hemangiomas from hemangiosarcomas. Hemangiosarcomas have an extremely poor prognosis with a three-year survival rate of just 38%. Mesurolle et al. reported that CNB was a potential method of distinguishing hemangioma from hemangiosarcoma, even though 37% of hemangiosarcomas are incorrectly diagnosed as hemangiomas using CNB [28, 29]. The difficulty in making a clear distinction between the two is due to the varying degree of cellular atypia found in hemangiosarcomas [30], and supports the need to perform a total excisional biopsy if hemangioma is suspected.

Conclusions

When ABC or CNB of a suspected breast tumor exhibits only hematic material, it is necessary to consider a vascular tumor in the differential diagnosis. Likewise, it is essential to perform a total excisional biopsy if hemangioma of the breast is suspected.
Written informed consent was obtained from the patients for publication of the case report and any accompanying images.

Acknowledgments

We want to thank Curtis R Lacy who participated in the discussion and English translation of this paper.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​4.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

NF and TO collected the data, images and clinical information. IT, HT and CS searched the relevant literatures. NF wrote the whole draft. IT, MY and AF performed the surgery. All authors approved the final manuscript.
Anhänge
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Metadaten
Titel
Breast hemangioma with difficulty in preoperative diagnosis: a case report
verfasst von
Naotake Funamizu
Isao Tabei
Chikako Sekine
Azusa Fuke
Mitsuo Yabe
Hiroshi Takeyama
Tomoyoshi Okamoto
Publikationsdatum
01.12.2014
Verlag
BioMed Central
Erschienen in
World Journal of Surgical Oncology / Ausgabe 1/2014
Elektronische ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-12-313

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