Background
Methods
Acute canine thromboembolic pulmonary hypertension model
Right heart catheterization
Magnetic resonance imaging
CMR analysis
RV and LV function
Flow quantification
Statistical analysis
Results
RV and LV function
CINE bSSFP | 4D flow CMR | ||
---|---|---|---|
RV | Axial | Axial | |
EDV (mL) | 34.5 ± 8.1 | 35.3 ± 10.2 | |
ESV (mL) | 19.6 ± 5.8 | 21.2 ± 6.8 | |
SV (mL) | 14.8 ± 3.1 | 14.1 ± 4.1 | |
EF | 0.44 ± 0.07 | 0.40 ± 0.06 | |
CO (L/min) | 1189 ± 286 | 1145 ± 417 | |
LV
|
Axial
|
Axial
|
Short-axis
|
EDV (mL) | 22.3 ± 5.4 | 23.8 ± 6.5 | 23.0 ± 6.2 |
ESV (mL) | 9.1 ± 3.6 | 12.5 ± 4.21 | 13.1 ± 3.81 |
SV (mL) | 13.1 ± 3.6 | 11.3 ± 3.01 | 9.9 ± 3.41,2 |
EF | 0.59 ± 0.11 | 0.48 ± 0.071 | 0.43 ± 0.091,2 |
CO (L/min) | 1059 ± 358 | 907 ± 2951 | 798 ± 3221,2 |
Flow quantification
Pulmonary arteries
2D Flow | 4D Flow | |||||||
---|---|---|---|---|---|---|---|---|
MPA | RPA | LPA | RPA + LPA | MPA | RPA | LPA | RPA + LPA | |
Pre + Post | 18.9 ± 4.51,2 | 10.7 ± 3.22 | 7.7 ± 3.82 | 18.4 ± 6.42 | 12.0 ± 3.91 | 7.6 ± 2.2 | 4.8 ± 2.1 | 12.6 ± 3.51 |
Pre | 19.25 ± 4.51,2 | 11.1 ± 2.92 | 8.0 ± 2.9 | 19.1 ± 5.42 | 12.2 ± 3.31 | 7.4 ± 2.3 | 4.8 ± 2.7 | 12.5 ± 4.0 |
Post | 18.6 ± 5.01,2 | 10.4 ± 3.82 | 7.3 ± 4.8 | 17.7 ± 7.72 | 11.8 ± 4.6 | 7.8 ± 2.3 | 4.9 ± 1.3 | 12.7 ± 3.5 |
TTP flow (ms) | TTP acceleration (ms) | |||||
---|---|---|---|---|---|---|
MPA | RPA | LPA | MPA | RPA | LPA | |
Pre + Post | 279 ± 170 | 298 ± 149 | 305 ± 145 | 219 ± 161 | 238 ± 150 | 223 ± 141 |
Pre | 339 ± 176 | 337 ± 161 | 351 ± 136 | 261 ± 162 | 270 ± 159 | 234 ± 149 |
Post | 230 ± 163 | 259 ± 144 | 248 ± 149 | 184 ± 167 | 206 ± 152 | 210 ± 147 |