Introduction
Patients and Methods
Case report
Analysis of the literature
Results
Pt. | Age (years) | Sex | Diagnosis | Duration of steroid treat- ment (years) | Steroid dose (mg/d) | Therapy | Clinical outcomea | Reference |
---|---|---|---|---|---|---|---|---|
1 | 17 (?)b | m | Kidney transplant | 1 | 40 | Surgery SR | Improvement | Lee 1975 [1] |
2 | 13 | m | Kidney transplant | 1.5 | 45 | SR, diet | Resolution | George 1983 [5] |
3 | 6 | m | JIA | 4 | 40 | Surgery SR | Improvement | Perling 1988 [6] |
4 | 11 | m | Pineoblastoma | 1 | 20 | Surgery | Progression of symptoms due to spread of tumor | Quint 1988 [7] |
5 | 6 | m | sJIA | 1 | 10-40 | Surgery | Resolution | Arroyo 1988 [8] |
6 | 16 | m | Kidney transplant | 3 | 0.4/kg | SR, diet | Resolution | Vazquez 1988 [9] |
7 | 10 | m | NS | 0.7 | 60 | SR, diet | Improvement | Shirai 1990 [10] |
8 | 11 | m | NS | 0.8 | 12-60 | Surgery | Improvement | Kano 1996 [15]c |
9 | 14 | f | NS | 0.25 | 24-80 | SR | Resolution | -„- |
10 | 14 | m | NS | 0.4 | 48-80 | SR | Resolution | -„- |
11 | 10 | m | HSP | 0.8 | 36-72 | SR | Resolution | -„- |
12 | 8 | f | Crohn disease | 6.5 | 10-60? | SR | Died from sepsis | Muňoz 2002 [11] |
13 | 14 | m | SLE | 0.8 | <60 | SR | Improvement | Miller 2002 [12] |
14 | 5 | f | NS | 1.4 | 5-60 | SR | Resolution | |
15 | 10 | f | NS | 0.4 | 20-60 | SR | Resolution | Kano 2005 [16] |
16 | 14 | f | SLE | 0.5 | 0.2/kg | SR | Resolution | Möller 2010 [17] |
17 | 11 | f | Sjögren syndrome | 0.6 | 0.5/kg | SR | Resolution | Möller 2010 [17] |
18 | 7 | f | sJIA | 1.5 | 40 | SR | Resolutiond | Möller 2010 [17] |
19 | 12 | f | Lung transplant | 0.06 | 25 | SR, diet | Resolution | Caruba 2010 [14] |
20 | 10 | f | Relapsing polychondritis | 0.4 | 30 | SR | Resolution | This report |
Pt. | Symptoms | Documented neurological findings | Approximate extent of lipomatosis | Imaging modality | Ref. |
---|---|---|---|---|---|
1 | Weakness/numbness of LE | Motor deficit LE > UE, dysesthesia LE & front of trunk | T1-T11 | Myelogram | [1] |
2 | Hip & low back pain, LE weakness | LE motor deficit; ankle clonus, Babinski sign | T1-L5 | Myelogram, CT | [5] |
3 | LE & thorax pain; loss of function of LE, bowel, and bladder | Paraplegia; sensory deficit below T6, poor anal sphincter tone | T2-T6 | Metrimazide CT myelogram | [6] |
4 | LE weakness, paresthesia, bowel/bladder dysfunction | Sensory deficit below T2-T3 | T3-T9 | MRI | [7] |
5 | Back pain, paraplegia | Weak tendon reflexes, sensory deficit to T6 | T6-T7* | CT | [8] |
6 | Upper back and chest pain, paraplegia | Flaccid paresis, Babinski sign, absent abdominal reflexes, decreased LE sense of vibration | T1-T12 | CT | [9] |
7 | Back pain, incontinence to urine, paraplegia | LEs flaccid paresis, Babinski sign | T11-L2/3* | Myelogram, MRI | [10] |
8 | Back pain, leg weakness | Paraplegia | T1-12* | CT myelogram | [15] |
9 | Lumbago | L3-S1* | MRI | [15] | |
10 | Lumbago, mid-thoracic back pain, pain with walking | T4-8*, L4-S1* | MRI | [15] | |
11 | Numbness | Cutaneous sensory deficit | T2-6* | MRI | [15] |
12 | Back pain, gait disturbance | Sensory deficit to T6-T7, UE strength 4/5, LE strength 1/5, absent knee & ankle DTRs, Babinski sign, absent abdominal reflexes | Entire spine | MRI | [11] |
13 | Back pain | Neurological exam normal | T1-L3+** | MRI | [12] |
14 | Back pain | T4-S1 | MRI | ||
15 | Back pain | T7-T9 | MRI | [16] | |
16 | Back pain, incontinence to stool and urine, paresthesias | Increased DTRs LE, loss of anal sphincter tone | T2- L5+** | MRI | [17] |
17 | Back pain, radicular pain | L4-5* | MRI | [17] | |
18 | Low back pain | T2-S4/5 | MRI | [17] | |
19 | Right LE weakness, left LE paresthesia, dysuria | T2-T11 | MRI | [14] | |
20 | Low back pain | Normal neurologic exam | T1-S5 | MRI | This report |