Background
Methods
Sample and design
Variables related to GI and CV risk classification
Statistical analysis
Sample size
Ethical considerations
Results
Characteristics of patients
Gastrointestinal risk
Cardiovascular history
Pharmacological treatment
Appropriateness of drug use in OA patients based on the GI and CV risk
Type of drug | Low GI risk N (%) | Moderate GI risk N (%) | High GI risk N (%) |
P-value** |
---|---|---|---|---|
N = 1283 | N = 5511 | N = 10311 | ||
SYSADOA
| 55 (4.3) | 120 (2.2) | 80 (0.8) |
<0.0001
|
Paracetamol
| 130 (10.1) | 535 (9.7) | 841 (8.2) |
0.001
|
Opioids
| 12 (0.9) | 55 (1.0) | 59 (0.6) |
0.008
|
Combinations of any of the 3*
| 80 (6.2) | 424 (7.7) | 1103 (10.3) |
<0.0001
|
NsNSAIDs
| 615 (47.9) | 2,567 (46.6) | 4,734 (45.9) |
0.337
|
nsNSAID+ GP***
|
344/615 (55.9) |
2,093/2,567 (81.5)
|
4,367/4,734 (92.2)
|
<0.0001
|
Cox-2 NSAID
| 294 (22.9) | 1,636 (29.7) | 3,669 (35.6) |
<0.0001
|
Cox-2 + GP***
|
96/294 (32.7)
|
880/1,636 (53.8)
|
2.800/3,669 (76.3)
|
<0.0001
|
Prescription | Low GI risk | Mod. GI risk | High GI risk |
P** value | |||
---|---|---|---|---|---|---|---|
No CV Hx* | CV Hx | No CV Hx | CV Hx | No CV Hx | CV Hx | ||
N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | ||
N = 1,144 | N = 62 | N = 4,373 | N = 871 | N = 5,697 | N = 4,323 | ||
SYSADOA
| 52 (4.6) | 0 (0.0) | 92 (2.1) | 22 (2.5) | 44 (0.8) | 33 (0.8) |
<0.0001
|
Paracetamol
| 108 (9.4) | 13 (21.0) | 391 (8.9) | 121 (13.9) | 331 (5.8) | 480 (11.1) |
<0.0001
|
Opioids
| 11 (1.0) | 1 (1.6) | 40 (0.9) | 11 (1.3) | 28 (0.5) | 28 (0.7) |
0.03
|
Combinations of any of the 3*
| 72 (6.2) | 5 (8.0) | 306 (7.0) | 97 (11.1) | 498 (8.7) | 586 (13.5) |
<0.0001
|
nsNSAIDs
| 554 (48.4) | 27 (43.5) | 2,091 (47.8) | 353 (40.5) | 2,807 (49.3) | 1,789 (41.4) |
<0.0001
|
nsNSAID+ GP***
|
307/554 (55.4)
|
18/27 (66.7)
|
1,687/2,091 (80.7)
|
302/353 (85.6)
|
2,552/2,807 (90.9)
|
1,691/1,789 (94.5)
|
<0.0001
|
Cox-2 NSAID
| 267 (23.3) | 13 (21.0) | 1,335 (30.5) | 227 (26.1) | 2,154 (37.8) | 1,428 (33.0) |
<0.0001
|
Cox-2 + GP***
|
89/267 (33.3)
|
4/13 (30.8)
|
694/1,335 (52.0)
|
149/227 (65.6)
| 1,554/2,154 (72.1)
|
1,177/1,428 (82.4)
|
<0.0001
|