Background
Methods
Recruitment of participants
Analytical methods
Statistical methods
Results
All subjects (n = 35) | |||||
---|---|---|---|---|---|
Baseline
|
After weight loss
|
p
|
r*
|
p*
| |
Age (years)
| 42.4 ± 15.2 | 0.23 | 0.2 | ||
Body Mass Index (kg/m
2
)
| 33.3 ± 4.2 | 28.9 ± 4.4 |
<0.001
| -0.58 |
<0.001
|
Body weight (kg)
| 95.4 ± 17.5 | 82.4 ± 14.7 |
<0.001
| -0.35 |
0.045
|
Fat mass (%)
| 41.8 ± 8.2 | 33.9 ± 9.9 |
<0.001
| -0.67 |
<0.001
|
Waist (cm)
| 106.4 ± 11.4 | 96.4 ± 11.7 |
<0.001
| -0.15 | 0.4 |
Hip (cm)
| 112.8 ± 10.3 | 104.4 ± 9.4 |
<0.001
| -0.58 |
<0.001
|
Waist to hip ratio
| 0.95 ± 0.08 | 0.92 ± 0.07 |
<0.001
| 0.28 | 0.1 |
Fasting glucose (mmol/l)
| 5.2 ± 0.5 | 5 ± 0.43 |
0.04
| 0.23 | 0.2 |
Fasting triglycerides (mmol/l)
| 1.23 ± 0.5 | 0.92 ± 0.36 |
0.001
| 0.17 | 0.3 |
HDL-cholesterol (mmol/l)
| 1.37 ± 0.3 | 1.28 ± 0.28 | 0.05 | -0.08 | 0.7 |
LDL-cholesterol (mmol/l)
| 3.3 ± 0.8 | 2.7 ± 0.59 |
<0.001
| 0.28 | 0.1 |
Total cholesterol (mmol/l)
| 5.2 ± 0.9 | 4.45 ± 0.61 |
<0.001
| 0.3 | 0.08 |
Fasting insulin (mU/l)
| 16.1 ± 8.6 | 12.06 ± 6.4 |
0.005
| -0.37 |
0.03
|
HOMA value
| 3.6 ± 2.04 | 2.6 ± 1.4 |
0.009
| -0.3 | 0.08 |
Circulating leptin (ng/ml)
| 35.7 ± 22.2 | 13.2 ± 18.2 |
<0.001
| -0.7 |
<0.001
|
Circulating omentin-1 (ng/ml)
| 44.9 ± 9.02 | 53.4 ± 8.8 |
<0.001
|
Men (n = 18) | |||||
---|---|---|---|---|---|
Baseline
|
After weight loss
|
P
|
r*
|
p*
| |
Age (years)
| 41.7 ± 15.1 | 0.28 | 0.25 | ||
Body Mass Index (kg/m
2
)
| 33.3 ± 4.23 | 28.9 ± 4.4 |
<0.001
| -0.67 |
0.002
|
Body Weight (kg)
| 102.6 ± 14.7 | 88.8 ± 13.2 |
<0.001
| -0.59 |
0.01
|
Fat mass (%)
| 36.2 ± 5.9 | 27.3 ± 7.6 |
<0.001
| -0.48 |
0.04
|
Waist (cm)
| 111.2 ± 7.2 | 99.1 ± 8.6 |
<0.001
| -0.47 |
0.045
|
Hip (cm)
| 111.4 ± 8.37 | 104 ± 8.9 |
<0.001
| -0.52 |
0.03
|
Waist to hip ratio
| 1 ± 0.05 | 0.95 ± 0.05 |
<0.001
| 0.11 | 0.6 |
Fasting glucose (mmol/l)
| 5.3 ± 0.27 | 5.1 ± 0.45 | 0.09 | 0.35 | 0.17 |
Fasting triglycerides (mmol/l)
| 1.37 ± 0.59 | 0.92 ± 0.37 |
0.002
| -0.05 | 0.8 |
HDL-cholesterol (mmol/l)
| 1.26 ± 0.25 | 1.2 ± 0.27 | 0.17 | -0.14 | 0.6 |
LDL-cholesterol (mmol/l)
| 3.5 ± 0.8 | 2.8 ± 0.6 |
0.001
| -0.05 | 0.8 |
Total cholesterol (mmol/l)
| 5.4 ± 0.9 | 4.4 ± 0.65 |
<0.001
| -0.07 | 0.8 |
Fasting insulin (mU/l)
| 14.9 ± 6.9 | 9.7 ± 5.6 |
0.005
| -0.38 | 0.13 |
HOMA value
| 3.5 ± 1.6 | 2.2 ± 1.2 |
0.005
| -0.37 | 0.14 |
Circulating Leptin (ng/ml)
| 23.1 ± 11.7 | 13.4 ± 7.8 |
<0.001
| -0.65 |
0.003
|
Circulating omentin-1 (ng/ml)
| 48.6 ± 8.3 | 56.4 ± 8.9 |
0.003
|
Women (n = 17) | |||||
---|---|---|---|---|---|
Baseline
|
After weight loss
|
P
|
r*
|
p*
| |
Age (years)
| 43.3 ± 15.6 | 0.2 | 0.4 | ||
Body Mass Index (kg/m
2
)
| 33.8 ± 6.45 | 29.2 ± 5.1 |
<0.001
| -0.69 |
0.002
|
Body Weight (kg)
| 87.7 ± 17.4 | 75.6 ± 13.4 |
<0.001
| -0.64 |
0.006
|
Fat mass (%)
| 47.6 ± 5.7 | 40.8 ± 6.8 |
<0.001
| -0.63 |
0.007
|
Waist (cm)
| 101.5 ± 12.9 | 93.6 ± 14.06 |
<0.001
| -0.44 | 0.08 |
Hip (cm)
| 114.2 ± 12.2 | 104.8 ± 10.2 |
<0.001
| -0.67 |
0.003
|
Waist to hip ratio
| 0.88 ± 0.07 | 0.89 ± 0.08 |
<0.001
| 0.13 | 0.6 |
Fasting glucose (mmol/l)
| 5.04 ± 0.6 | 5.01 ± 0.38 |
0.047
| -0.07 | 0.8 |
Fasting triglycerides (mmol/l)
| 1.06 ± 0.45 | 0.92 ± 0.36 |
0.001
| 0.1 | 0.7 |
HDL-cholesterol (mmol/l)
| 1.5 ± 0.35 | 1.37 ± 0.27 | 0.47 | 0.21 | 0.4 |
LDL-cholesterol (mmol/l)
| 3.1 ± 0.86 | 2.7 ± 0.6 |
0.001
| 0.35 | 0.2 |
Total cholesterol (mmol/l)
| 5.06 ± 0.97 | 4.5 ± 0.57 |
<0.001
| 0.43 | 0.09 |
Fasting insulin (mU/l)
| 12.03 ± 9.6 | 9.6 ± 7.4 | 0.05 | -0.64 |
0.005
|
HOMA value
| 2.54 ± 2.2 | 2 ± 1.6 | 0.05 | -0.55 |
0.02
|
Circulating Leptin (ng/ml)
| 32.5 ± 7.8 | 12.8 ± 3.8 |
<0.001
| -0.74 |
0.001
|
Circulating omentin-1 (ng/ml)
| 41.1 ± 8.3 | 50.2 ± 7.6 |
0.001
|
All subjects | Men | Women | ||||
---|---|---|---|---|---|---|
Beta
|
P
|
Beta
|
p
|
Beta
|
p
| |
Sex
| -2.76 |
0.01
| --- | --- | ||
Body Mass Index (kg/m
2
)
| -2.74 |
0.01
| -2.3 |
0.038
| -2.9 |
0.01
|
Fasting insulin (mU/l)
| -0.27 | 0.8 | 0.09 | 0.9 | -0.71 | 0.5 |
Adjusted R Square
|
0.39
|
0.28
|
0.36
|
All subjects (n = 35) | Men (n = 18) | Women (n = 17) | ||||
---|---|---|---|---|---|---|
r
|
P
|
R
|
p
|
r
|
p
| |
Body Mass Index (kg/m
2
)
| -0.47 |
0.003
| -0.52 |
0.02
| -0.55 |
0.02
|
Body Weight (kg)
| -0.44 |
0.01
| -0.47 |
0.04
| -0.53 |
0.03
|
Fat mass (%)
| -0.29 | 0.09 | -0.27 | 0.2 | -0.31 | 0.2 |
Waist (cm)
| -0.04 | 0.8 | -0.28 | 0.2 | 0.2 | 0.4 |
Hip (cm)
| -0.31 | 0.06 | -0.3 | 0.2 | -0.38 | 0.1 |
Waist to hip ratio
| 0.19 | 0.2 | -0.2 | 0.4 | 0.4 | 0.1 |
Fasting glucose (mmol/l)
| -0.04 | 0.8 | -0.28 | 0.2 | 0.12 | 0.6 |
Fasting triglycerides (mmol/l)
| -0.1 | 0.6 | -0.3 | 0.2 | 0.2 | 0.4 |
HDL-cholesterol (mmol/l)
| 0.37 |
0.03
| 0.21 | 0.4 | 0.43 | 0.08 |
LDL-cholesterol (mmol/l)
| 0.04 | 0.8 | -0.24 | 0.3 | 0.37 | 0.1 |
Total Cholesterol (mmol/l)
| 0.09 | 0.6 | -0.35 | 0.1 | 0.5 | 0.06 |
Fasting insulin (mU/l)
| -0.45 |
0.01
| -0.5 |
0.03
| -0.53 |
0.03
|
HOMA index
| -0.42 |
0.02
| -0.48 |
0.04
| -0.46 | 0.08 |
Circulating Leptin (ng/ml)
| -0.4 |
0.025
| -0.49 |
0.04
| -0.26 | 0.34 |