Background
Methods
Subjects
Control | Obese | T2D | |
---|---|---|---|
n | 14 | 22 | 20 |
Age (yr) | 45 [41;59] | 49 [20;60] | 55 [40;63]#,$ |
Gender (males/females) | 5/9 | 20/2 | 12/8 |
BMI (kg/m2) | 23.85 [21.20;32.40] | 33.60 [27.90;38.50] * | 31.85 [22.80;39.10]# |
Fasting glucose (mg/dl) | 5.03 [4.50;5.85] | 5.50 [4.30;6.80] * | 7.37 [5.11;12.50]#,$ |
HbA1c (%) | 5.40 [5.00;5.90] | 5.45 [4.80;6.50] | 7.40 [5.80;11.70]#,$ |
Fasting insulin (μUI/ml) | 5.90 [2.90;13.90] | 11.55 [3.90;35.70] * | 11.65 [2.10;38.40]# |
HOMA | 1.33 [0.60;3.03] | 3.15 [0.85;10.79] | 3.85 [0.66;16.38]# |
BMR (kcal/24 h) | 1368 [1066;1920] | 1895 [1590;2350] * | 1701 [1264;2062]#,$ |
TC (mg/dl) | 209 [170;292] | 201[138;250] | 184 [104;219]# |
TG (mg/dl) | 90 [51;187] | 140 [62;531] * | 130 [44;335] |
LDL-C (mg/dl) | 122 [86;178] | 131 [92;165] | 112 [35;139]#,$ |
HDL-C (mg/dl) | 66 [40;103] | 40 [26;54] * | 46 [37;74]#,$ |
Total BA (μmol/l) | 1.06 [0.46;1.90] | 1.49 [0.64;4.06]* | 1.34 [0.53;5.54] |
DCA (μmol/l) | 0.38 [0.14;1.02] | 0.44 [0.03;1.07] | 0.62 [0.11;1.66]# |
CDCA (μmol/l) | 0.36 [0.09;1.25] | 0.60 [0.31;2.38] | 0.43 [0.09;2.78] |
CA (μmol/l) | 0.22 [0.08;0.50] | 0.35 [0.09;1.20] * | 0.26 [0.1;1.10] |
Study design
Statistical analysis
Results
Circulating bile acids and glucose homeostasis
DCA | CDCA | CA | |||||||
---|---|---|---|---|---|---|---|---|---|
β
|
95% confidence interval
|
p-value
|
β
|
95% confidence interval
|
p-value
|
β
|
95% confidence interval
|
p-value
| |
Age
| 0.01 | [0.002;0.02] | 0.02 | 0.001 | [-0.02;0.02] | NS | 0.004 | [-0.003;0.01] | NS |
Men
| 0.002 | [-0.19;0.19] | NS | 0.39 | [0.04;0.74] | 0.03 | 0.17 | [0.03;0.31] | 0.02 |
BMI
| 0.02 | [0.0006;0.04] | 0.04 | 0.04 | [0.004;0.07] | 0.03 | 0.01 | [-0.003;0.03] | NS |
Fasting glucose
| 0.8 | [0.03;0.12] | 0.001 | 0.05 | [-0,04;0.14] | NS | 0.03 | [-0.03;0.04] | NS |
Fasting insulin
| 0.02 | [0.01;0.03] | < 10-4 | 0.04 | [0.02;0.06] | 0.001 | 0.02 | [0.006;0.02] | 0.001 |
HbA1C
| 0.04 | [-0.03;0.12] | NS | -0.05 | [-0.18;0.08] | NS | -0.04 | [-0.09;0.02] | NS |
HOMA-R
| 0.07 | [0.04;0.19] | < 10-4 | 0.09 | [0.04;0.14] | 0.001 | 0.03 | [0.007;0.05] | 0.09 |
BMR
| 0.0001 | [-0.0002;0.0004] | NS | 0.0008 | [0.0002;0.001] | 0.01 | 0.0002 | [2.4*10-7 ;0.0005] | 0.05 |
CDCA | |||
---|---|---|---|
β
|
95% confidence interval
|
p-value
| |
Center
| NS | ||
- Center 2 | 1 | ||
- Center 1 | 0.466 | [-0.037;0.969] | |
Group
| NS | ||
-Controls | 1 | ||
-Obeses | 0.144 | [-0.614;0.902] | |
-Diabetics | 0.259 | [-0.534;1.053] | |
Age
| -0.001 | [-0.019;0.018] | NS |
BMI
| -0.013 | [-0.066;0.039] | NS |
HbA1C
| -0.044 | [-0.242;0.155] | NS |
HOMA
| 0.116 | [0.035;0.196] | 0.01 |
BMR
| -0.00007 | [-0.0009;0.0007] | NS |
TG
| 0.129 | [-0.129;0.387] | NS |
LDL-C
| -0.133 | [-0.961;0.695] | NS |
CA
| |||
β
|
95% confidence interval
|
p-value
| |
Group
| NS | ||
-Controls | 1 | ||
-Obeses | 0.350 | [0.013;0.687] | |
-Diabetics | 0.164 | [-0.189;0.517] | |
Age
| 0.04 | ||
-Center 2 | -0.008 | ||
-Center 1 | 0.009 | ||
BMI
| -0.02 | [-0.038;0.005] | NS |
HbA1C
| -0.015 | [-0.093;0.063] | |
HOMA
| 0.045 | [0.014;0.077] | 0.01 |
BMR
| -0.0003 | [-0.0006;0.0001] | NS |
TG
| 0.053 | [-0.048;0.155] | NS |
LDL-C
| -0.162 | [-0.487;0.164] | NS |
DCA
| |||
β
|
95% confidence interval
|
p-value
| |
Center
| NS | ||
- Center 2 | 1 | ||
- Center 1 | 0.176 | [-0.102;0.454] | |
Group
| NS | ||
-Controls | 1 | ||
-Obeses | -0.067 | [-0.486;0.352] | |
-Diabetics | 0.229 | [-0.204;0.662] | |
Age
| 0.007 | [-0.003.0.017] | NS |
BMI
| 0.004 | [-0.025.0.033] | NS |
HbA1C
| -0.064 | [-0.169;0.041] | NS |
HOMA
| 0.062 | [0.018.0.105] | 0.007 |
BMR
| 0.00001 | [-0.0004;0.00048] | NS |
TG
| -0.004 | [-0.146;0.137] | NS |
LDL-C
| 0.007 | [-0.411;0.425] | NS |