Introduction
Materials and methods
Population of study
Gender | |
---|---|
Male | 46 (66%) |
Female | 24 (34%) |
Age (y)
| |
Median | 65 |
Range | 39-89 |
Primary site
| |
Lung | 34(48%) |
Colon | 10(14%) |
Breast | 2(3%) |
Pancreas | 2 (3%) |
Uterus | 1 (1,5%) |
Sarcoma | 6 (9%) |
Stomach | 3 (4, %) |
Prostate | 1(1,5%) |
Liver | 4(6%) |
Endometrial | 1(1,5%) |
Melanoma | 1(1,5%) |
Unknown | 5 (7%) |
Protocols: inclusion criteria and dose prescription
SBRT procedure
Evaluation of dosimetric and technical data
Evaluation of clinical data
Results
Dosimetric and technical data
Parameter | All | Lung | Liver | Abdomen |
---|---|---|---|---|
PTV
| ||||
Volume [cm
3
]
| 78 ± 78 | 55 ± 55 | 146 ± 116 | 115 ± 82 |
Mean dose [%]
| 101.0 ± 2.9 | 101.2 ± 1.0 | 100.6 ± 1.6 | 100.3 ± 0.5 |
St. Dev. [%]
| 2.7 ± 0.6 | 2.9 ± 0.5 | 2.3 ± 0.8 | 2.1 ± 0.6 |
D
1%
[%]
| 106.0 ± 1.8 | 106.8 ± 1.5 | 104.3 ± 1.6 | 104.4 ± 1.4 |
D
95%
[%]
| 96.2 ± 1.0 | 96.1 ± 0.9 | 96.2 ± 1.5 | 96.4 ± 0.8 |
V
95%
[%]
| 97.3 ± 1.9 | 97.1 ± 1.7 | 97.2 ± 3.0 | 97.9 ± 1.5 |
V
107
[%]
| 1.5 ± 5.1 | 2.1 ± 6.0 | 0.1 ± 0.2 | 0.0 ± 0.1 |
Healthy tissue
| ||||
Volume [cm
3
]
| 30660 ± 8928 | 29283 ± 7493 | 36232 ± 13301 | 31510 ± 8805 |
Mean [Gy]
| 1.2 ± 0.7 | 1.1 ± 0.8 | 1.4 ± 0.3 | 1.3 ± 0.6 |
V
10 Gy
[%]
| 3.3 ± 2.7 | 3.0 ± 3.0 | 4.0 ± 1.3 | 3.9 ± 2.4 |
CI
95%
| 1.2 ± 0.3 | 1.3 ± 0.3 | 1.2 ± 0.3 | 1.2 ± 0.3 |
Dose Int. [Gy*cm
3
*10
4
]
| 3.5 ± 2.1 | 3.1 ± 2.0 | 5.0 ± 2.1 | 4.1 ± 1.8 |
Parameter | All | Lung | Liver | Abdomen |
---|---|---|---|---|
Ipsilateral Lung
| ||||
Volume [cm
3
]
| 1814.5 ± 619.0 | 1861.9 ± 610.5 | 1686.4 ± 797.2 | 1407.2 ± 76.1 |
Mean [Gy]
| 4.4 ± 3.0 | 4.9 ± 2.8 | 3.1 ± 3.1 | 0.2 ± 0.0 |
V
5 Gy
[%]
| 24.6 ± 18.3 | 27.6 ± 17.6 | 16.1 ± 17.0 | 0.0 ± 0.0 |
V
10 Gy
[%]
| 15.5 ± 12.6 | 17.4 ± 12.3 | 9.5 ± 11.8 | 0.0 ± 0.0 |
V
20 Gy
[%]
| 5.8 ± 4.8 | 6.6 ± 4.6 | 3.3 ± 5.4 | 0.0 ± 0.0 |
Contralateral Lung
| ||||
Volume [cm
3
]
| 1703 ± 629 | 1774 ± 615 | 1352 ± 765 | 1484 ± 335 |
Mean [Gy]
| 1.6 ± 2.1 | 1.8 ± 2.2 | 1.0 ± 0.6 | 0.2 ± 0.1 |
V
5 Gy
[%]
| 7.0 ± 14.3 | 8.0 ± 15.7 | 3.8 ± 3.5 | 0.0 ± 0.1 |
V
10 Gy
[%]
| 2.7 ± 8.3 | 3.2 ± 9.2 | 0.1 ± 0.3 | 0.0 ± 0.0 |
V
20 Gy
[%]
| 0.9 ± 2.9 | 1.1 ± 3.2 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Spinal cord
| ||||
Volume [cm
3
]
| 65 ± 35 | 61 ± 36 | 76 ± 33 | 78 ± 28 |
D
0.1 cm3
[Gy]
| 9.9 ± 5.5 | 10.2 ± 6.1 | 9.4 ± 3.1 | 8.8 ± 4.9 |
D
1%
[Gy]
| 9.0 ± 4.5 | 9.1 ± 4.8 | 8.8 ± 3.2 | 8.4 ± 4.8 |
Liver
| ||||
Volume [cm
3
]
| 1473 ± 409 | 1735 ± 606 | 1546 ± 434 | 1266 ± 193 |
Mean [Gy]
| 8.0 ± 5.8 | 3.2 ± 2.6 | 12.9 ± 3.7 | 3.8 ± 3.6 |
V
15 Gy
[%]
| 18.8 ± 17.1 | 3.2 ± 2.2 | 33.7 ± 10.7 | 6.2 ± 8.9 |
Ipsilateral Kidney
| ||||
Volume [cm
3
]
| 137 ± 38 | - | 134 ± 42 | 141 ± 38 |
Mean
| 5.0 ± 5.3 | - | 2.5 ± 2.4 | 7.8 ± 6.5 |
V
15 Gy
[%]
| 11.5 ± 20.0 | - | 2.2 ± 3.6 | 22.4 ± 26.0 |
Contralateral kidney
| ||||
Volume [cm
3
]
| 139 ± 35 | - | 126 ± 37 | 151 ± 30 |
Mean [Gy]
| 2.7 ± 2.1 | - | 2.0 ± 1.1 | 3.4 ± 2.7 |
V
15 Gy
[%]
| 0.2 ± 0.7 | - | 0.0 ± 0.0 | 0.4 ± 1.0 |
Stomach
| ||||
Volume [cm
3
]
| 104 ± 40 | - | 104 ± 40 | - |
Mean [Gy]
| 7.3 ± 2.8 | - | 7.3 ± 2.8 | - |
V
36 Gy
[%]
| 0.0 ± 0.0 | - | 0.0 ± 0.0 | - |
D
0.5 cm3
[Gy]
| 20.6 ± 3.6 | - | 20.6 ± 3.6 | - |
Small Bowell
| ||||
Volume [cm
3
]
| 1255 ± 569 | - | - | 1255 ± 569 |
Mean [Gy]
| 4.1 ± 4.4 | - | - | 4.1 ± 4.4 |
V
36 Gy
[%]
| 0.0 ± 0.0 | - | - | 0.0 ± 0.0 |
D
0.5 cm3
[Gy]
| 24.3 ± 13.0 | - | - | 24.3 ± 13.0 |
Heart
| ||||
Volume [cm
3
]
| 624 ± 190 | 629 ± 174 | 676 ± 298 | 365 ± 0.0 |
Mean [Gy]
| 4.3 ± 4.0 | 4.5 ± 4.2 | 4.3 ± 3.3 | 0.9 ± -0.0 |
D
1%
[Gy]
| 15.3 ± 9.6 | 15.9 ± 9.7 | 14.9 ± 10.7 | 6.1 ± -0.0 |
Oesophagus
| ||||
Volume [cm
3
]
| 39 ± 43 | 32 ± 34 | 91 ± 86 | - |
Mean [Gy]
| 3.8 ± 2.9 | 3.8 ± 3.0 | 3.3 ± 3.7 | - |
D
1%
[Gy]
| 13.6 ± 7.9 | 13.9 ± 8.0 | 10.8 ± 10.2 | - |
Mean ± SD | Range | |
---|---|---|
MU
| 2780 ± 1493 | [629÷6734] |
MU/Gy
| 283.6 ± 79.7 | [164.1÷551.5] |
MU/arc
| 1955 ± 1312 | [315÷6099] |
MU/deg
| 7.6 ± 4.3 | [1.1÷17.2] |
DR [MU/min]
| 1541 ± 621 | [327÷2400] |
Gantry speed [deg/s]
| 4.4 ± 1.6 | [1.4÷6.0] |
CP aperture [cm]
| 1.7 ± 0.8 | [0.2÷4.4] |
CP area [cm
2
]
| 14.5 ± 10.4 | [3.6÷55.2] |
Arc length [deg]
| 258.5 ± 70.5 | [158÷358] |
Beam on time [min]
| 1.7 ± 0.7 | [0.9÷4.4] |