Background
Patients and methods
Study design
Inclusion and exclusion criteria
Diagnostic criteria and therapeutic regimens of nasopharyngeal carcinoma
Clinical assessment
Assessment of atherosclerosis
Biochemical analysis
Statistical analysis
Results
Baseline characteristics of the study patients
NPC Patients (n = 105)
|
Controls (n = 25)
|
p value
| |
---|---|---|---|
Age, y |
52.43 ± 10.23
|
50.68 ± 11.49
|
0.280
|
Gender (female; male)
|
33; 72
|
9; 16
|
0.660
|
Body mass index, kg/m
2
|
23.78 ± 3.61
|
22.61 ± 2.95
|
0.142
|
Median (IQR)duration after radiotherapy (months)
|
48 (31, 77)
|
---
| |
Right CCA IMT, mm
|
1.025 ± 0.611
|
0.612 ± 0.074
|
<0.001
|
Left CCA IMT, mm
|
1.036 ± 0.541
|
0.643 ± 0.111
|
<0.001
|
Mean CCA IMT, mm
|
1.031 ± 0.539
|
0.634 ± 0.111
|
<0.001
|
Cholesterol, mg/dL
| |||
Total
|
201.96 ± 37.52
|
187.17 ± 24.28
|
0.021
|
HDL-C
|
61.07 ± 15.23
|
67.62 ± 14.55
|
0.059
|
LDL-C
|
118.22 ± 35.06
|
102.13 ± 18.39
|
0.003
|
Triglyceride, mg/dL
|
114.39 ± 63.82
|
86.83 ± 35.74
|
0.006
|
Glucose, mg/dL
|
90.96 ±14.03
|
86.79 ± 8.12
|
0.165
|
HBA1c
|
5.70 ± 0.47
|
5.56 ± 0.23
|
0.146
|
hs-CRP, mg/L
|
3.50 ± 1.38
|
1.12 ± 1.00
|
<0.001
|
WBC counts (X10
3
/mL)
|
4.86 ± 1.62
|
5.32 ± 1.02
|
0.189
|
RBC counts (X10
6
/ml)
|
4.61 ± 0.67
|
4.95 ± 0.49
|
0.035
|
Platelet counts (X10
3
/mL)
|
225.74 ± 64.74
|
207.75 ± 39.44
|
0.195
|
Carotid plaques and vascular risk factors
Without carotid plaques (n = 67)
|
With carotid plaques (n = 38)
|
p value
| |
---|---|---|---|
Age, y
|
48.86 ± 9.8
|
58.79 ±7.77
|
<0.001
|
Gender (female; male)
|
23; 44
|
10; 28
|
0.395
|
Body mass index, kg/m
2
|
23.65 ±3.62
|
24.01 ± 3.63
|
0.624
|
Median (IQR) duration after radiotherapy (months)
|
45.0 (25.5, 63.5)
|
63.5 (32.5, 9.5)
|
0.023
|
Cholesterol, mg/dL
| |||
Total
|
200.39 ± 32.26
|
204.67 ± 45.58
|
0.617
|
HDL-C
|
60.78 ± 16.26
|
61.59 ± 13.44
|
0.797
|
LDL-C
|
116.39 ± 29.58
|
121.37 ± 43.20
|
0.536
|
Triglyceride, mg/dL
|
120.96 ± 71.34
|
103.01 ± 46.89
|
0.174
|
Glucose, mg/dL
|
89.18 ± 9.77
|
94.02 ± 19.08
|
0.157
|
HBA1c
|
5.60 ± 0.29
|
5.86 ± 0.64
|
0.022
|
hs-CRP, mg/L
|
3.81 ± 1.81
|
2.96 ± 1.03
|
0.406
|
WBC counts (X10
3
/mL)
|
4.83 ± 1.74
|
4.91 ± 1.42
|
0.814
|
RBC counts (X10
6
/ml)
|
4.51 ± 0.59
|
4.78 ± 0.76
|
0.052
|
Platelet counts (X10
3
/mL)
|
221.06 ± 65.66
|
233.83 ± 63.17
|
0.342
|
Correlation analysis of the effects of vascular risk factors on CCA IMT
Variables
|
Correlation coefficient
|
P value
|
---|---|---|
Age
|
0.598
|
<0.001
|
Duration of radiotherapy therapy (months)
|
0.615
|
<0.001
|
hs-CRP
|
0.222
|
0.014
|
Glucose, mg/dL
|
0.147
|
0.144
|
HBA1c
|
0.200
|
0.049
|
Total Cholesterol
|
-0.074
|
0.459
|
HDL
|
-0.030
|
0.765
|
LDL-C
|
0.013
|
0.895
|
Body mass index
|
0.045
|
0.652
|
Platelet count
|
0.326
|
0.001
|
Duration of radiotherapy was significantly associated with CCA IMT
Model 1
|
Model 2
| |||||
---|---|---|---|---|---|---|
Regression coefficients
|
Standard error
|
p value
|
Regression coefficients
|
Standard error
|
p value
| |
Constant
|
-0.811
|
0.227
|
0.001
|
-0.772
|
0.218
|
0.001
|
Duration after radiotherapy
|
0.005
|
0.001
|
<0.001
|
0.005
|
0.001
|
<0.001
|
Age
|
0.024
|
0.004
|
<0.001
|
0.023
|
0.004
|
<0.001
|
Platelet count
|
0.001
|
0.001
|
0.026
|
0.001
|
0.001
|
0.026
|