Background
Methods
Treatment of SCC of the anal canal
Study cohort selection and data extraction
Sources of research support
Results
Patient characteristics
Characteristics | Number of patients (percent) |
---|---|
Median age
| 60 years (44–82) |
Sex
| |
Male
| 25 (38%) |
Female
| 41 (62%) |
HIV status
| |
Positive
| 1 (2%) |
Negative
| 65 (99%) |
Smoking status
| |
Smoker (have ever)
| 17 (26%) |
Non-smoker
| 49 (74%) |
Alcohol consumption
| |
Drinker
| 17 (26%) |
Non-drinker
| 49 (74%) |
ECOG status
| |
0
| 42 (64%) |
1
| 19 (29%) |
2
| 3 (5%) |
3
| 2 (3%) |
4
| 0 (0%) |
Stage of tumor
| |
I
| 26 (39%) |
II
| 15 (23%) |
III
| 25 (38%) |
IV
| 0(0%) |
Histology
| |
Squamous cell carcinoma
| 49 (74%) |
Squamous carcinoma (keratinizing)
| 8 (12%) |
Squamous cell carcinoma (basaloid)
| 5 (8%) |
Tubulovillous adenoma
| 2 (3%) |
Adenocarcinoma
| 2 (3%) |
Treatment dose intensity
Capecitabine dose administered | Number of patients (percent) |
---|---|
Number of patients starting at full dose (750–825 mg/m
2
)
| |
- No subsequent dose reduction
| 59 (78%) |
- Dose reduction
| 13 (22%) |
- Discontinuation
| 0 (0%) |
Number of patients starting at dose level −1 (500–749 mg/m
2
)
| |
- Received
| 7 (11%) |
- Dose reduction
| 0 (0%) |
- Discontinuation
| 0 (0%) |
Mean weeks of capectiabine
| 5.5 (2.5-6) |
Mitomycin dose administered
|
Number of patients (percent)
|
- Full dose (12 mg/m
2
)
| 63 (95%) |
- Dose level −1
| 3 (5%) |
Radiation technique | Number of patients treated n(%) | |
---|---|---|
3D-CRT | 50 (76%) | |
IMRT | 16 (24%) | |
Radiation dose planned n(%)
|
Number of patients with dose reduction
| |
10-15 Gy | 0 (0%) | 0 |
15-20 Gy | 0 (0%) | 0 |
20-25 Gy | 0 (0%) | 0 |
25-30 Gy | 3 (5%) | 0 |
30-35 Gy | 1 (2%) | 0 |
35-40 Gy | 0 (0%) | 0 |
40-45 Gy | 1 (2%) | 0 |
45-50 Gy | 6 (9%) | 0 |
50-55 Gy | 45 (70%) | 0 |
55-60 Gy | 9 (14%) | 1 (Reduced to 12 Gy) |
60-65 Gy | 1 (2%) | 0 |
Median: 51.9 Gy
| ||
Range: 25.0-63 Gy
|
Total: 1 (out of 66) (2%)
|
Patient toxicities
Toxicity grade of adverse event | Number of patients (percent) N = 66 |
---|---|
0
| 35 (53%) |
1
| 19 (29%) |
2
| 7 (11%) |
3
| 2 (3%) |
4
| 3 (5%) |
Case descriptions of grade 3 and 4 toxicity description (case by case)
| |
Case 1, grade 3 | Grade 2 stomatitis, grade 3 diarrhea |
Case 2, grade 3 | Grade 3 diarrhea, stool incontinence |
Case 3, grade 4 | Grade 4 diarrhea |
Case 4, grade 4 | Grade 4 diarrhea, stool incontinence |
Case 5, grade 4 | Grade 4 diarrhea |
Toxicity grade | Number of patients (percent) |
---|---|
1
| 19 (29%) |
2
| 5 (8%) |
3
| 42 (63%) |