Oral squamous cell carcinoma (OSCC) accounts for approximately 3% of all malignancies and more than 90% of cancers of the oral cavity and oropharynx [
1,
2]. The reported etiological agents and risk factors for oral cancer include tobacco use, frequent alcohol consumption, the use of areca nut, a compromised immune system and a history of dietary habits that can cause cancer, as well as less established factors such as infection with certain types of human papillomaviruses [
3]. OSCC mostly affects adult men between the sixth and seventh decades of life [
4,
5]. The most affected sites, in decreasing order, are the tongue, oropharynx, lips, floor of the mouth, gingiva, hard palate and buccal mucosa [
4]. Clinical stages (tumor, node and metastasis, or TNM) of OSCCs at diagnosis have an important influence on the survival and prognosis of patients. Unfortunately, approximately 60% to 65% of oral cancer patients are in TNM stages III and IV. Delay in diagnosis consists of either patient delay or professional delay [
5]. The treatment of choice for OSCCs is wide
en bloc excision of the tumor in the soft tissue, with the involved bone and post-operative radiotherapy depending on the final histopathological results [
6]. Three patients with OSCCs, along with the clinical and radiological findings, are described in this case presentation.