Background
Materials and methods
Tumor tissue specimens and DNA extraction
Cases | Age | Gender* | Diagnosis** | Follow-up*** | Recurrence**** | Outcome***** |
---|---|---|---|---|---|---|
1 | 16 | F | GCT | 9y | none | NED |
2 | 16 | F | GCT | 12.5y | 1 | NED |
3 | 18 | M | GCT | 11.2y | 1 | NED |
4 | 21 | M | GCT | 11y | none | NED |
5 | 25 | M | GCT | 12.3y | none | NED |
6 | 41 | F | GCT | 20.6y | 2 | AWD |
7 | 55 | M | GCT | 16.2y | 2 | AWD |
8 | 47 | F | chondrosarcoma | 20y | none | NED |
9 | 7 | F | OS | 4y | metastasis (+) | DOD |
10 | 41 | M | OS | 9 m | metastasis (+) | DOD |
11 | 58 | F | OS | 20y | none | NED |
12 | 65 | F | OS | 6 m | metastasis (+) | DOD |
13a | 18 | M | OS (primary) | 4 m | metastasis (+) | DOD |
13b | OS (metastasis) |
Hybridization and analysis of array CGH
Evaluation of array CGH
Statistical analysis
Results
Overall array CGH results in aggressive bone tumors
Clinical relevance in GCT
Primary vs. Metastatic OS
location | Gene name | metastasis (≧1.30) | primary tumor | m/p ratio | |
---|---|---|---|---|---|
1p
| 1p36 | CDC2L1(p58) | 1.39 | 1.33 | 1.05 |
1p36.33 | PPKCZ | 1.52 | 1.24 | 1.23 | |
1p36.33 | TP73 | 1.48 | 1.58 | 0.94 | |
1p36.31 | D1S214 | 1.76 | 1.21 | 1.45* | |
1p36.22 | D1S1635 | 1.88 | 1.33 | 1.41* | |
1p36.13 | D1S199 | 1.51 | 1.22 | 1.24 | |
1q
| 1q21 | WI-5663 | 1.73 | 1.64 | 1.05 |
5p
| 5p13 | DAB2 | 1.87 | 1.55 | 1.21 |
8q
| 8q24.11-q24 | EXT1 | 1.44 | 1.03 | 1.40* |
8q24-qter | PTK2 | 1.51 | 1.31 | 1.15 | |
8q tel | SHGC-3110 | 1.40 | 1.29 | 1.09 | |
8q tel | U11829 | 1.35 | 1.16 | 1.16 | |
9p
| 9p11.2 | AFM137XA11 | 1.52 | 1.16 | 1.31* |
12p
| 12p tel | 8 M16/SP6 | 1.49 | 1.08 | 1.38* |
12p tel | SHGC-5557 | 1.52 | 1.34 | 1.13 | |
12p13 | CCND2 | 1.71 | 1.29 | 1.33* | |
12p13.1-p12 | CDLN1B(p27) | 1.53 | 1.25 | 1.22 | |
14q
| 14q32.32 | AKT1 | 1.68 | 1.51 | 1.11 |
14q tel | IGH(D14S308) | 1.51 | 1.16 | 1.30* | |
14q tel | IGH(SHGC-36156) | 1.39 | 1.14 | 1.22 | |
17p
| 17p tel | 282 M15/SP6 | 1.52 | 1.14 | 1.33* |
17p13.3 | HIC1 | 1.42 | 1.04 | 1.37* | |
17p13.1 | TP53(p53) | 1.40 | 1.19 | 1.18 | |
17p12-17p11.2 | LLGL1 | 1.67 | 2.06 | 0.81* | |
17p12-17p11.2 | FLI, TOP3A | 1.60 | 1.88 | 0.85* | |
18q
| 18q11.2 | LAMA3 | 1.73 | 0.87 | 1.99* |
20q
| 20q13.1-q13.2 | PTPN1 | 1.46 | 1.43 | 1.02 |
20q13 | TNFRSF6B(DCR3) | 1.50 | 1.23 | 1.22 | |
21q
| 21q22.3 | RUNX1(AML1) | 1.40 | 1.16 | 1.21 |
21q22 | DYRK1A | 1.37 | 1.13 | 1.21 | |
21q tel | PCNT2(KEN) | 1.56 | 1.30 | 1.20 |