Review
Introduction and presentation of the expert recommendations of the French-language Intensive Care Society (Société de Réanimation de Langue Française (SRLF))
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Median and bounds within range [7–9] = “strong agreement”
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Median and bounds within range [1–3] = “strong disagreement”
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Median within range [7–9] with lower bound < 7 = “weak agreement”
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Median within range [1–3] with upper bound > 3 = “weak disagreement”
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Median within range [4–6] = “uncertainty”
Field 1: Definition – epidemiology – prognosis
Field 2: Diagnostic approach
Field 3: Therapeutic aspects
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Presence of active bleeding (type, potential severity),
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Mechanism of thrombocytopenia (central or peripheral),
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Etiology,
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Risk of thrombosis,
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Risk of hemorrhage (platelet disorders, invasive procedures or surgery), and
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Associated treatments (strong agreement).
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Severe sepsis, with risk of severe hemorrhage or use of anticoagulant,
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Invasive procedure,
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Pre- or postsurgical setting (weak agreement).
Field 4: Thrombocytopenia and sepsis
Field 5: Iatrogenic thrombocytopenia
Heparin-induced thrombocytopenia
Field 6: Thrombotic microangiopathy
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Atypical HUS: failure to correct thrombocytopenia and/or to improve renal function at day 5 of standard treatment
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Acquired TTP: PC not doubled by day 5 of standard treatment or diseaseprogression (increased thrombocytopenia or onset of organ damage) duringintensive first-line treatment or on reducing the frequency of PE (strong agreement).