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Alzheimer's Research & Therapy
Erschienen in: Alzheimer's Research & Therapy 5/2013

01.10.2013 | Review

Autophagic/lysosomal dysfunction in Alzheimer’s disease

verfasst von: Miranda E Orr, Salvatore Oddo

Erschienen in: Alzheimer's Research & Therapy | Ausgabe 5/2013

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Abstract

Autophagy serves as the sole catabolic mechanism for degrading organelles and protein aggregates. Increasing evidence implicates autophagic dysfunction in Alzheimer’s disease (AD) and other neurodegenerative diseases associated with protein misprocessing and accumulation. Under physiologic conditions, the autophagic/lysosomal system efficiently recycles organelles and substrate proteins. However, reduced autophagy function leads to the accumulation of proteins and autophagic and lysosomal vesicles. These vesicles contain toxic lysosomal hydrolases as well as the proper cellular machinery to generate amyloid-beta, the major component of AD plaques. Here, we provide an overview of current research focused on the relevance of autophagic/lysosomal dysfunction in AD pathogenesis as well as potential therapeutic targets aimed at restoring autophagic/lysosomal pathway function.
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Metadaten
Titel
Autophagic/lysosomal dysfunction in Alzheimer’s disease
verfasst von
Miranda E Orr
Salvatore Oddo
Publikationsdatum
01.10.2013
Verlag
BioMed Central
Erschienen in
Alzheimer's Research & Therapy / Ausgabe 5/2013
Elektronische ISSN: 1758-9193
DOI
https://doi.org/10.1186/alzrt217

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