Skip to main content
Erschienen in: Alzheimer's Research & Therapy 4/2011

01.08.2011 | Review

Technical aspects of amyloid imaging for Alzheimer's disease

verfasst von: Paul Edison, Rainer Hinz, David J Brooks

Erschienen in: Alzheimer's Research & Therapy | Ausgabe 4/2011

Einloggen, um Zugang zu erhalten

Abstract

[11C]Pittsburgh Compound B positron emission tomography has now been extensively used to evaluate the amyloid load in different types of dementia and has become a powerful research tool in the field of neurodegenerative diseases. In the present short review we discuss the properties of amyloid imaging agent [11C]Pittsburgh Compound B, the different modalities of molecular imaging, image processing and data analysis, and newer amyloid imaging agents.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984, 34: 939-944.CrossRefPubMed McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984, 34: 939-944.CrossRefPubMed
2.
Zurück zum Zitat American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. Arlington, VA: American Psychiatric Association, 4 American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. Arlington, VA: American Psychiatric Association, 4
3.
Zurück zum Zitat Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P: Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurol. 2010, 9: 1118-1127. 10.1016/S1474-4422(10)70223-4.CrossRefPubMed Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P: Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurol. 2010, 9: 1118-1127. 10.1016/S1474-4422(10)70223-4.CrossRefPubMed
4.
Zurück zum Zitat Greene JD, Baddeley AD, Hodges JR: Analysis of the episodic memory deficit in early Alzheimer's disease: evidence from the doors and people test. Neuropsychologia. 1996, 34: 537-551. 10.1016/0028-3932(95)00151-4.CrossRefPubMed Greene JD, Baddeley AD, Hodges JR: Analysis of the episodic memory deficit in early Alzheimer's disease: evidence from the doors and people test. Neuropsychologia. 1996, 34: 537-551. 10.1016/0028-3932(95)00151-4.CrossRefPubMed
5.
Zurück zum Zitat Price BH, Gurvit H, Weintraub S, Geula C, Leimkuhler E, Mesulam M: Neuropsychological patterns and language deficits in 20 consecutive cases of autopsy-confirmed Alzheimer's disease. Arch Neurol. 1993, 50: 931-937.CrossRefPubMed Price BH, Gurvit H, Weintraub S, Geula C, Leimkuhler E, Mesulam M: Neuropsychological patterns and language deficits in 20 consecutive cases of autopsy-confirmed Alzheimer's disease. Arch Neurol. 1993, 50: 931-937.CrossRefPubMed
6.
Zurück zum Zitat Esteban-Santillan C, Praditsuwan R, Ueda H, Geldmacher DS: Clock drawing test in very mild Alzheimer's disease. J Am Geriatr Soc. 1998, 46: 1266-1269.CrossRefPubMed Esteban-Santillan C, Praditsuwan R, Ueda H, Geldmacher DS: Clock drawing test in very mild Alzheimer's disease. J Am Geriatr Soc. 1998, 46: 1266-1269.CrossRefPubMed
7.
Zurück zum Zitat Erkinjuntti T, Rockwood K: Vascular dementia. Semin Clin Neuropsychiatry. 2003, 8: 37-45. 10.1053/scnp.2003.50004.CrossRefPubMed Erkinjuntti T, Rockwood K: Vascular dementia. Semin Clin Neuropsychiatry. 2003, 8: 37-45. 10.1053/scnp.2003.50004.CrossRefPubMed
8.
Zurück zum Zitat Dickson DW: The pathogenesis of senile plaques. J Neuropathol Exp Neurol. 1997, 56: 321-339. 10.1097/00005072-199704000-00001.CrossRefPubMed Dickson DW: The pathogenesis of senile plaques. J Neuropathol Exp Neurol. 1997, 56: 321-339. 10.1097/00005072-199704000-00001.CrossRefPubMed
9.
Zurück zum Zitat Silverman DH, Small GW, Chang CY, Lu CS, Kung De Aburto MA, Chen W, Czernin J, Rapoport SI, Pietrini P, Alexander GE, Schapiro MB, Jagust WJ, Hoffman JM, Welsh-Bohmer KA, Alavi A, Clark CM, Salmon E, de Leon MJ, Mielke R, Cummings JL, Kowell AP, Gambhir SS, Hoh CK, Phelps ME: Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome. JAMA. 2001, 286: 2120-2127. 10.1001/jama.286.17.2120.CrossRefPubMed Silverman DH, Small GW, Chang CY, Lu CS, Kung De Aburto MA, Chen W, Czernin J, Rapoport SI, Pietrini P, Alexander GE, Schapiro MB, Jagust WJ, Hoffman JM, Welsh-Bohmer KA, Alavi A, Clark CM, Salmon E, de Leon MJ, Mielke R, Cummings JL, Kowell AP, Gambhir SS, Hoh CK, Phelps ME: Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome. JAMA. 2001, 286: 2120-2127. 10.1001/jama.286.17.2120.CrossRefPubMed
10.
Zurück zum Zitat Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Mathis CA: Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci. 2001, 69: 1471-1484. 10.1016/S0024-3205(01)01232-2.CrossRefPubMed Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Mathis CA: Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci. 2001, 69: 1471-1484. 10.1016/S0024-3205(01)01232-2.CrossRefPubMed
11.
Zurück zum Zitat Mathis CA, Wang Y, Holt DP, Huang GF, Debnath ML, Klunk WE: Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem. 2003, 46: 2740-2754. 10.1021/jm030026b.CrossRefPubMed Mathis CA, Wang Y, Holt DP, Huang GF, Debnath ML, Klunk WE: Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem. 2003, 46: 2740-2754. 10.1021/jm030026b.CrossRefPubMed
12.
Zurück zum Zitat Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE: A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg Med Chem Lett. 2002, 12: 295-298. 10.1016/S0960-894X(01)00734-X.CrossRefPubMed Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE: A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg Med Chem Lett. 2002, 12: 295-298. 10.1016/S0960-894X(01)00734-X.CrossRefPubMed
13.
Zurück zum Zitat Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergstrom M, Savitcheva I, Huang GF, Estrada S, Ausen B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Langstrom B: Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol. 2004, 55: 306-319. 10.1002/ana.20009.CrossRefPubMed Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergstrom M, Savitcheva I, Huang GF, Estrada S, Ausen B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Langstrom B: Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol. 2004, 55: 306-319. 10.1002/ana.20009.CrossRefPubMed
14.
Zurück zum Zitat Rowe CC, Ng S, Ackermann U, Gong SJ, Pike K, Savage G, Cowie TF, Dickinson KL, Maruff P, Darby D, Smith C, Woodward M, Merory J, Tochon-Danguy H, O'Keefe G, Klunk WE, Mathis CA, Price JC, Masters CL, Villemagne VL: Imaging β-amyloid burden in aging and dementia. Neurology. 2007, 68: 1718-1725. 10.1212/01.wnl.0000261919.22630.ea.CrossRefPubMed Rowe CC, Ng S, Ackermann U, Gong SJ, Pike K, Savage G, Cowie TF, Dickinson KL, Maruff P, Darby D, Smith C, Woodward M, Merory J, Tochon-Danguy H, O'Keefe G, Klunk WE, Mathis CA, Price JC, Masters CL, Villemagne VL: Imaging β-amyloid burden in aging and dementia. Neurology. 2007, 68: 1718-1725. 10.1212/01.wnl.0000261919.22630.ea.CrossRefPubMed
15.
Zurück zum Zitat Edison P, Rowe CC, Rinne JO, Ng S, Ahmed I, Kemppainen N, Villemagne VL, O'Keefe G, Nagren K, Chaudhury KR, Masters CL, Brooks DJ: Amyloid load in Parkinson's disease dementia and Lewy Body dementia measured with [11C]PIB-PET. J Neurol Neurosurg Psychiatry. 2008, 79: 1331-1338. 10.1136/jnnp.2007.127878.CrossRefPubMed Edison P, Rowe CC, Rinne JO, Ng S, Ahmed I, Kemppainen N, Villemagne VL, O'Keefe G, Nagren K, Chaudhury KR, Masters CL, Brooks DJ: Amyloid load in Parkinson's disease dementia and Lewy Body dementia measured with [11C]PIB-PET. J Neurol Neurosurg Psychiatry. 2008, 79: 1331-1338. 10.1136/jnnp.2007.127878.CrossRefPubMed
16.
Zurück zum Zitat Nord berg A: Amyloid imaging in Alzheimer's disease. Curr Opin Neurol. 2007, 20: 398-402. 10.1097/WCO.0b013e3281a47744.CrossRef Nord berg A: Amyloid imaging in Alzheimer's disease. Curr Opin Neurol. 2007, 20: 398-402. 10.1097/WCO.0b013e3281a47744.CrossRef
17.
Zurück zum Zitat Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND, Lopresti BJ, Ziolko S, Bi W, Paljug WR, Debnath ML, Hope CE, Isanski BA, Hamilton RL, DeKosky ST: Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain. 2008, 131 (Pt 6): 1630-1645.PubMedCentralCrossRefPubMed Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND, Lopresti BJ, Ziolko S, Bi W, Paljug WR, Debnath ML, Hope CE, Isanski BA, Hamilton RL, DeKosky ST: Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain. 2008, 131 (Pt 6): 1630-1645.PubMedCentralCrossRefPubMed
18.
Zurück zum Zitat Natterer F, Wubbeling F: Mathematical Methods in Image Reconstruction. Series: Monographs on Mathematical Modeling and Computation. 2001, Society for Industrial and Applied MathematicsCrossRef Natterer F, Wubbeling F: Mathematical Methods in Image Reconstruction. Series: Monographs on Mathematical Modeling and Computation. 2001, Society for Industrial and Applied MathematicsCrossRef
19.
Zurück zum Zitat Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ: A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol. 1984, 15: 217-227. 10.1002/ana.410150302.CrossRefPubMed Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ: A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol. 1984, 15: 217-227. 10.1002/ana.410150302.CrossRefPubMed
20.
Zurück zum Zitat Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF: Preclinical properties of 18F-AV-45: a PET agent for Aβ plaques in the brain. J Nucl Med. 2009, 50: 1887-1894. 10.2967/jnumed.109.065284.PubMedCentralCrossRefPubMed Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF: Preclinical properties of 18F-AV-45: a PET agent for Aβ plaques in the brain. J Nucl Med. 2009, 50: 1887-1894. 10.2967/jnumed.109.065284.PubMedCentralCrossRefPubMed
21.
Zurück zum Zitat Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, Holden J, Houle S, Huang SC, Ichise M, Iida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, Carson RE: Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab. 2007, 27: 1533-1539. 10.1038/sj.jcbfm.9600493.CrossRefPubMed Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, Holden J, Houle S, Huang SC, Ichise M, Iida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, Carson RE: Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab. 2007, 27: 1533-1539. 10.1038/sj.jcbfm.9600493.CrossRefPubMed
22.
Zurück zum Zitat Blomquist G, Engler H, Nordberg A, Ringheim A, Wall A, Forsberg A, Estrada S, Frandberg P, Antoni G, Langstrom B: Unidirectional influx and net accumulation of PIB. Open Neuroimag J. 2008, 2: 114-125. 10.2174/1874440000802010114.PubMedCentralCrossRefPubMed Blomquist G, Engler H, Nordberg A, Ringheim A, Wall A, Forsberg A, Estrada S, Frandberg P, Antoni G, Langstrom B: Unidirectional influx and net accumulation of PIB. Open Neuroimag J. 2008, 2: 114-125. 10.2174/1874440000802010114.PubMedCentralCrossRefPubMed
23.
Zurück zum Zitat Blomqvist G: On the construction of functional maps in positron emission tomography. J Cereb Blood Flow Metab. 1984, 4: 629-632. 10.1038/jcbfm.1984.89.CrossRefPubMed Blomqvist G: On the construction of functional maps in positron emission tomography. J Cereb Blood Flow Metab. 1984, 4: 629-632. 10.1038/jcbfm.1984.89.CrossRefPubMed
24.
Zurück zum Zitat Gunn RN, Gunn SR, Cunningham VJ: Positron emission tomography compartmental models. J Cereb Blood Flow Metab. 2001, 21: 635-652.CrossRefPubMed Gunn RN, Gunn SR, Cunningham VJ: Positron emission tomography compartmental models. J Cereb Blood Flow Metab. 2001, 21: 635-652.CrossRefPubMed
25.
Zurück zum Zitat Logan J, Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer DJ, MacGregor RR, Hitzemann R, Bendriem B, Gatley SJ, et al: Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab. 1990, 10: 740-747. 10.1038/jcbfm.1990.127.CrossRefPubMed Logan J, Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer DJ, MacGregor RR, Hitzemann R, Bendriem B, Gatley SJ, et al: Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab. 1990, 10: 740-747. 10.1038/jcbfm.1990.127.CrossRefPubMed
26.
Zurück zum Zitat Patlak CS, Blasberg RG: Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab. 1985, 5: 584-590. 10.1038/jcbfm.1985.87.CrossRefPubMed Patlak CS, Blasberg RG: Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab. 1985, 5: 584-590. 10.1038/jcbfm.1985.87.CrossRefPubMed
27.
Zurück zum Zitat Patlak CS, Blasberg RG, Fenstermacher JD: Graphical evaluation of blood-tobrain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab. 1983, 3: 1-7. 10.1038/jcbfm.1983.1.CrossRefPubMed Patlak CS, Blasberg RG, Fenstermacher JD: Graphical evaluation of blood-tobrain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab. 1983, 3: 1-7. 10.1038/jcbfm.1983.1.CrossRefPubMed
28.
Zurück zum Zitat Cunningham VJ, Jones T: Spectral analysis of dynamic PET studies. J Cereb Blood Flow Metab. 1993, 13: 15-23. 10.1038/jcbfm.1993.5.CrossRefPubMed Cunningham VJ, Jones T: Spectral analysis of dynamic PET studies. J Cereb Blood Flow Metab. 1993, 13: 15-23. 10.1038/jcbfm.1993.5.CrossRefPubMed
29.
Zurück zum Zitat Lammertsma AA, Bench CJ, Hume SP, Osman S, Gunn K, Brooks DJ, Frackowiak RS: Comparison of methods for analysis of clinical [11C]raclopride studies. J Cereb Blood Flow Metab. 1996, 16: 42-52.CrossRefPubMed Lammertsma AA, Bench CJ, Hume SP, Osman S, Gunn K, Brooks DJ, Frackowiak RS: Comparison of methods for analysis of clinical [11C]raclopride studies. J Cereb Blood Flow Metab. 1996, 16: 42-52.CrossRefPubMed
30.
Zurück zum Zitat Lammertsma AA, Hume SP: Simplified reference tissue model for PET receptor studies. Neuroimage. 1996, 4 (3 Pt 1): 153-158.CrossRefPubMed Lammertsma AA, Hume SP: Simplified reference tissue model for PET receptor studies. Neuroimage. 1996, 4 (3 Pt 1): 153-158.CrossRefPubMed
31.
Zurück zum Zitat Edison P, Archer HA, Hinz R, Hammers A, Pavese N, Tai YF, Hotton G, Cutler D, Fox N, Kennedy A, Rossor M, Brooks DJ: Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology. 2007, 68: 501-508. 10.1212/01.wnl.0000244749.20056.d4.CrossRefPubMed Edison P, Archer HA, Hinz R, Hammers A, Pavese N, Tai YF, Hotton G, Cutler D, Fox N, Kennedy A, Rossor M, Brooks DJ: Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology. 2007, 68: 501-508. 10.1212/01.wnl.0000244749.20056.d4.CrossRefPubMed
32.
Zurück zum Zitat Villemagne VL, Pike KE, Chetelat G, Ellis KA, Mulligan RS, Bourgeat P, Ackermann U, Jones G, Szoeke C, Salvado O, Martins R, O'Keefe G, Mathis CA, Klunk WE, Ames D, Masters CL, Rowe CC: Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease. Ann Neurol. 2011, 69: 181-192. 10.1002/ana.22248.PubMedCentralCrossRefPubMed Villemagne VL, Pike KE, Chetelat G, Ellis KA, Mulligan RS, Bourgeat P, Ackermann U, Jones G, Szoeke C, Salvado O, Martins R, O'Keefe G, Mathis CA, Klunk WE, Ames D, Masters CL, Rowe CC: Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease. Ann Neurol. 2011, 69: 181-192. 10.1002/ana.22248.PubMedCentralCrossRefPubMed
33.
Zurück zum Zitat Carson RE, Channing MA, Blasberg RG, Dunn BB, Cohen RM, Rice KC, Herscovitch P: Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab. 1993, 13: 24-42. 10.1038/jcbfm.1993.6.CrossRefPubMed Carson RE, Channing MA, Blasberg RG, Dunn BB, Cohen RM, Rice KC, Herscovitch P: Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab. 1993, 13: 24-42. 10.1038/jcbfm.1993.6.CrossRefPubMed
34.
Zurück zum Zitat Friston KJ, Frith CD, Liddle PF, Frackowiak RS: Plastic transformation of PET images. J Comput Assist Tomogr. 1991, 15: 634-639. 10.1097/00004728-199107000-00020.CrossRefPubMed Friston KJ, Frith CD, Liddle PF, Frackowiak RS: Plastic transformation of PET images. J Comput Assist Tomogr. 1991, 15: 634-639. 10.1097/00004728-199107000-00020.CrossRefPubMed
35.
Zurück zum Zitat Worsley KJ, Evans AC, Marrett S, Neelin P: A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab. 1992, 12: 900-918. 10.1038/jcbfm.1992.127.CrossRefPubMed Worsley KJ, Evans AC, Marrett S, Neelin P: A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab. 1992, 12: 900-918. 10.1038/jcbfm.1992.127.CrossRefPubMed
36.
Zurück zum Zitat Friston KJ, Frith CD, Liddle PF, Dolan RJ, Lammertsma AA, Frackowiak RS: The relationship between global and local changes in PET scans. J Cereb Blood Flow Metab. 1990, 10: 458-466. 10.1038/jcbfm.1990.88.CrossRefPubMed Friston KJ, Frith CD, Liddle PF, Dolan RJ, Lammertsma AA, Frackowiak RS: The relationship between global and local changes in PET scans. J Cereb Blood Flow Metab. 1990, 10: 458-466. 10.1038/jcbfm.1990.88.CrossRefPubMed
37.
Zurück zum Zitat Nelissen N, Van Laere K, Thurfjell L, Owenius R, Vandenbulcke M, Koole M, Bormans G, Brooks DJ, Vandenberghe R: Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease. J Nucl Med. 2009, 50: 1251-1259. 10.2967/jnumed.109.063305.CrossRefPubMed Nelissen N, Van Laere K, Thurfjell L, Owenius R, Vandenbulcke M, Koole M, Bormans G, Brooks DJ, Vandenberghe R: Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease. J Nucl Med. 2009, 50: 1251-1259. 10.2967/jnumed.109.063305.CrossRefPubMed
38.
Zurück zum Zitat Vandenberghe R, Van Laere K, Ivanoiu A, Salmon E, Bastin C, Triau E, Hasselbalch S, Law I, Andersen A, Korner A, Minthon L, Garraux G, Nelissen N, Bormans G, Buckley C, Owenius R, Thurfjell L, Farrar G, Brooks DJ: 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial. Ann Neurol. 2010, 68: 319-329. 10.1002/ana.22068.CrossRefPubMed Vandenberghe R, Van Laere K, Ivanoiu A, Salmon E, Bastin C, Triau E, Hasselbalch S, Law I, Andersen A, Korner A, Minthon L, Garraux G, Nelissen N, Bormans G, Buckley C, Owenius R, Thurfjell L, Farrar G, Brooks DJ: 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial. Ann Neurol. 2010, 68: 319-329. 10.1002/ana.22068.CrossRefPubMed
39.
Zurück zum Zitat Clark CM, Schneider JA, Bedell BJ, Beach TG, Bilker WB, Mintun MA, Pontecorvo MJ, Hefti F, Carpenter AP, Flitter ML, Krautkramer MJ, Kung HF, Coleman RE, Doraiswamy PM, Fleisher AS, Sabbagh MN, Sadowsky CH, Reiman EP, Zehntner SP, Skovronsky DM: Use of florbetapir-PET for imaging β-amyloid pathology. JAMA. 2011, 305: 275-283. 10.1001/jama.2010.2008.CrossRefPubMed Clark CM, Schneider JA, Bedell BJ, Beach TG, Bilker WB, Mintun MA, Pontecorvo MJ, Hefti F, Carpenter AP, Flitter ML, Krautkramer MJ, Kung HF, Coleman RE, Doraiswamy PM, Fleisher AS, Sabbagh MN, Sadowsky CH, Reiman EP, Zehntner SP, Skovronsky DM: Use of florbetapir-PET for imaging β-amyloid pathology. JAMA. 2011, 305: 275-283. 10.1001/jama.2010.2008.CrossRefPubMed
40.
Zurück zum Zitat Okamura N, Yanai K: Florbetapir (18F), a PET imaging agent that binds to amyloid plaques for the potential detection of Alzheimer's disease. IDrugs. 2010, 13: 890-899.PubMed Okamura N, Yanai K: Florbetapir (18F), a PET imaging agent that binds to amyloid plaques for the potential detection of Alzheimer's disease. IDrugs. 2010, 13: 890-899.PubMed
41.
Zurück zum Zitat Barthel H, Gertz HJ, Dresel S, Peters O, Bartenstein P, Buerger K, Hiemeyer F, Wittemer-Rump SM, Seibyl J, Reininger C, Sabri O: Cerebral amyloid-beta PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol. 2011, 10: 424-435. 10.1016/S1474-4422(11)70077-1.CrossRefPubMed Barthel H, Gertz HJ, Dresel S, Peters O, Bartenstein P, Buerger K, Hiemeyer F, Wittemer-Rump SM, Seibyl J, Reininger C, Sabri O: Cerebral amyloid-beta PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol. 2011, 10: 424-435. 10.1016/S1474-4422(11)70077-1.CrossRefPubMed
42.
Zurück zum Zitat Edison P, Brooks DJ, Turkheimer FE, Archer HA, Hinz R: Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility. Neuroimage. 2009, 48: 329-338. 10.1016/j.neuroimage.2009.06.079.CrossRefPubMed Edison P, Brooks DJ, Turkheimer FE, Archer HA, Hinz R: Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility. Neuroimage. 2009, 48: 329-338. 10.1016/j.neuroimage.2009.06.079.CrossRefPubMed
Metadaten
Titel
Technical aspects of amyloid imaging for Alzheimer's disease
verfasst von
Paul Edison
Rainer Hinz
David J Brooks
Publikationsdatum
01.08.2011
Verlag
BioMed Central
Erschienen in
Alzheimer's Research & Therapy / Ausgabe 4/2011
Elektronische ISSN: 1758-9193
DOI
https://doi.org/10.1186/alzrt87

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.